EFHC2 and SPATA18

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		EFHC2	SPATA18
Description		EF-hand domain containing 2	spermatogenesis associated 18
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Microtubule Axonemal Microtubule Cilium Motile Cilium Ciliary Basal Body Sperm Flagellum Cell Projection Axonemal A Tubule Inner Sheath	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Matrix Cytosol Membrane Intracellular Membrane-bounded Organelle Intracellular Membraneless Organelle
	Molecular Function	Calcium Ion Binding Protein Binding	Protein Binding Lipid Binding Identical Protein Binding Molecular Condensate Scaffold Activity Cardiolipin Binding
	Biological Process	Regulation Of Neuron Projection Development Flagellated Sperm Motility Cellular Response To Leukemia Inhibitory Factor	CDP-diacylglycerol Biosynthetic Process Cardiolipin Biosynthetic Process Mitochondrial Protein Catabolic Process Mitophagy By Internal Vacuole Formation Cardiolipin Acyl-chain Remodeling Positive Regulation Of Cardiolipin Metabolic Process
Pathways
Drugs
Diseases
GWAS		Body mass index and diastolic blood pressure (bivariate analysis) ( 33539483) Glaucoma (primary open-angle) ( 33627673) Mean arterial pressure ( 29403010)	Height ( 31562340) Hip circumference adjusted for BMI ( 28552196) Platelet count ( 29403010) Type 2 diabetes ( 30054458) Uterine fibroids ( 30194396)
Interacting Genes		100 interacting genes: - AASDHPPT ARHGEF5 ARMC7 ATOSB CABP2 CACNB4 CARD9 CCDC102B CCDC120 CCDC13 CCDC57 CCHCR1 CCNG2 CDKN2A CLIC3 COPE CPNE2 CPNE7 CYFIP1 DCLK1 DDX6 DGCR6 DRC7 EDC3 EFHC1 EGLN3 EMD ENKD1 ESRRG EXOC8 EXOSC5 FAM107A FAM124B FAM221B FBXL19 GEM GLYCTK GOLGA1 GPKOW GRB2 GYS1 HDAC4 HGS HNRNPLL INPP5J JAKMIP2 KANK2 KCTD7 KIF9 L3MBTL2 LMNB2 LMO2 LNX1 LONRF1 MAGOHB MAPK9 MID2 MISP MTCL2 MYLIP MYO5B NCDN NCK2 NDOR1 NEK6 NFKBID NME7 NR3C1 PBLD PHF1 PIBF1 PICK1 PLOD3 POLR1C PRPF18 PTK6 QARS1 RAD51D RCOR3 RECK RHOBTB3 RUNX1T1 SNRNP25 SPATA18 SPG21 STK16 TBC1D1 TBC1D22B TEKT4 TRIM42 TRIM50 TSSK3 TUBGCP4 TXK U2AF1 USP2 ZBTB16 ZFHX3 ZZZ3	13 interacting genes: AIMP2 CARD10 CCDC102B DRC4 EFHC2 GOLGA2 HOXA1 LRIF1 MAD1L1 PAXIP1 PIBF1 TACC3 TGM7
Entrez ID		80258	132671
HPRD ID		06540	14050
Ensembl ID		ENSG00000183690	ENSG00000163071
Uniprot IDs		Q5JST6	A0A140VKF4 Q8TC71
PDB IDs		2Z13 2Z14 7UNG 8J07
Enriched GO Terms of Interacting Partners?		Cytoplasm Protein Binding Protein Phosphorylation Cytoskeleton Regulation Of Podosome Assembly Phosphorylation Centrosome	Positive Regulation Of Protein Modification Process Ciliary Basal Body Cytoskeleton Mitotic Spindle Organization Regulation Of Protein Modification Process Mitotic Spindle Microtubule Cytoskeleton Organization Involved In Mitosis Centriolar Satellite Microtubule-based Process Positive Regulation Of Protein Metabolic Process Spindle Organization Spindle Pole Microtubule Cytoskeleton Organization Activation Of Protein Kinase Activity Mitotic Spindle Assembly Semicircular Canal Formation MAD1 Complex Abducens Nerve Formation Optokinetic Behavior Mitotic Spindle Assembly Checkpoint MAD1-MAD2 Complex Negative Regulation Of Prostaglandin Biosynthetic Process Microtubule Spindle Assembly Deactivation Of Mitotic Spindle Assembly Checkpoint Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Interleukin-4 Receptor Binding Chorion Development
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