EFHC2 and COPE

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		EFHC2	COPE
Description		EF-hand domain containing 2	coat protein complex I subunit epsilon
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GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Microtubule Axonemal Microtubule Cilium Motile Cilium Ciliary Basal Body Sperm Flagellum Cell Projection Axonemal A Tubule Inner Sheath	Golgi Membrane Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane COPI Vesicle Coat Transport Vesicle COPI-coated Vesicle COPI-coated Vesicle Membrane Cytoplasmic Vesicle
	Molecular Function	Calcium Ion Binding Protein Binding	Structural Molecule Activity Protein Binding
	Biological Process	Regulation Of Neuron Projection Development Flagellated Sperm Motility Cellular Response To Leukemia Inhibitory Factor	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Intra-Golgi Vesicle-mediated Transport Protein Transport Vesicle-mediated Transport Protein Localization To Axon
Pathways			COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic
Drugs
Diseases
GWAS		Body mass index and diastolic blood pressure (bivariate analysis) ( 33539483) Glaucoma (primary open-angle) ( 33627673) Mean arterial pressure ( 29403010)
Interacting Genes		100 interacting genes: - AASDHPPT ARHGEF5 ARMC7 ATOSB CABP2 CACNB4 CARD9 CCDC102B CCDC120 CCDC13 CCDC57 CCHCR1 CCNG2 CDKN2A CLIC3 COPE CPNE2 CPNE7 CYFIP1 DCLK1 DDX6 DGCR6 DRC7 EDC3 EFHC1 EGLN3 EMD ENKD1 ESRRG EXOC8 EXOSC5 FAM107A FAM124B FAM221B FBXL19 GEM GLYCTK GOLGA1 GPKOW GRB2 GYS1 HDAC4 HGS HNRNPLL INPP5J JAKMIP2 KANK2 KCTD7 KIF9 L3MBTL2 LMNB2 LMO2 LNX1 LONRF1 MAGOHB MAPK9 MID2 MISP MTCL2 MYLIP MYO5B NCDN NCK2 NDOR1 NEK6 NFKBID NME7 NR3C1 PBLD PHF1 PIBF1 PICK1 PLOD3 POLR1C PRPF18 PTK6 QARS1 RAD51D RCOR3 RECK RHOBTB3 RUNX1T1 SNRNP25 SPATA18 SPG21 STK16 TBC1D1 TBC1D22B TEKT4 TRIM42 TRIM50 TSSK3 TUBGCP4 TXK U2AF1 USP2 ZBTB16 ZFHX3 ZZZ3	14 interacting genes: ARF1 CDC42 CDC42EP3 COPA COPB1 COPG1 COPG2 EFHC2 ERCC6 MBD1 RCHY1 SCYL1 TMED10 WBP2
Entrez ID		80258	11316
HPRD ID		06540	06089
Ensembl ID		ENSG00000183690	ENSG00000105669
Uniprot IDs		Q5JST6	M0QXB4 O14579
PDB IDs		2Z13 2Z14 7UNG 8J07	6TZT 6U3V
Enriched GO Terms of Interacting Partners?		Cytoplasm Protein Binding Protein Phosphorylation Cytoskeleton Regulation Of Podosome Assembly Phosphorylation Centrosome	COPI Vesicle Coat COPI-coated Vesicle COPI-coated Vesicle Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Coat Transport Vesicle Intra-Golgi Vesicle-mediated Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Golgi Vesicle Transport Golgi Membrane Vesicle-mediated Transport Intracellular Protein Localization Intracellular Protein Transport Golgi Apparatus Structural Molecule Activity Establishment Of Golgi Localization Intracellular Transport Establishment Of Protein Localization Positive Regulation Of Pseudopodium Assembly Organelle Transport Along Microtubule Golgi Localization Cellular Localization Establishment Of Localization In Cell Endoplasmic Reticulum Membrane Protein Transport Microtubule-based Movement Dendritic Spine Organization Transport Along Microtubule Cytoplasmic Vesicle Neuron Projection Organization Postsynapse Organization Cytoskeleton-dependent Intracellular Transport Membrane Invagination Mitotic Cleavage Furrow Ingression Microtubule-based Transport Secretion Response To Metformin Cytoskeletal Regulatory Protein Binding Cytosol To ERGIC Protein Transport Cis-Golgi Network Protein Localization To ERGIC COPI-coated Vesicle Budding Cell Leading Edge Regulation Of Actin Filament Organization Establishment Of Organelle Localization Cleavage Furrow Ingression GBD Domain Binding Storage Vacuole Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein
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