AP3M1 and SLC12A4

Number of citations of the paper that reports this interaction (PubMedID 40355756)
172

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		AP3M1	SLC12A4
Description		adaptor related protein complex 3 subunit mu 1	solute carrier family 12 member 4
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GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Early Endosome Golgi Apparatus Membrane AP-3 Adaptor Complex Clathrin Adaptor Complex Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Postsynaptic Recycling Endosome Axon Cytoplasm	Lysosomal Membrane Plasma Membrane Membrane Synapse
	Molecular Function	Protein Binding Small GTPase Binding	Protein Binding ATP Binding Symporter Activity Chloride:monoatomic Cation Symporter Activity Potassium:chloride Symporter Activity Protein Kinase Binding Transmembrane Transporter Activity Protein Serine/threonine Kinase Binding
	Biological Process	Protein Targeting To Lysosome Intracellular Protein Transport Endocytosis Anterograde Axonal Transport Protein Transport Vesicle-mediated Transport Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Anterograde Synaptic Vesicle Transport Platelet Dense Granule Organization Postsynaptic Neurotransmitter Receptor Internalization Melanosome Assembly	Monoatomic Ion Transport Potassium Ion Transport Cell Volume Homeostasis Chemical Synaptic Transmission Chloride Ion Homeostasis Potassium Ion Homeostasis Transmembrane Transport Potassium Ion Transmembrane Transport Chloride Transmembrane Transport Potassium Ion Import Across Plasma Membrane
Pathways		Association of TriC/CCT with target proteins during biosynthesis	Cation-coupled Chloride cotransporters
Drugs			Potassium chloride Bumetanide
Diseases
GWAS		Cardiac troponin-I levels ( 31014085) Primary tooth development (number of teeth) ( 23704328) Primary tooth development (time to first tooth eruption) ( 23704328) Refractive error ( 32231278)	Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)
Interacting Genes		14 interacting genes: AGTRAP AQP4 ARNT2 CRMP1 DVL3 IL36RN RUFY1 SIPA1L2 SLC12A4 SPAG16 TGOLN2 TRIM14 TRIM23 TRIM9	10 interacting genes: AP3M1 ATF7IP CNFN CYSRT1 KRTAP12-2 KRTAP19-2 MB21D2 MTNR1B TMEM102 ZNF655
Entrez ID		26985	6560
HPRD ID		16496	04987
Ensembl ID		ENSG00000185009	ENSG00000124067
Uniprot IDs		B4DRN6 Q9Y2T2	B4DF30 Q9UP95
PDB IDs		9C58 9C59 9C5A 9C5B 9C5C	6KKR 6KKT 6KKU 7AIP 7AIQ 7AIR 7TTH 7TTI
Enriched GO Terms of Interacting Partners?		Cerebrospinal Fluid Circulation
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