AP3M1 and SIPA1L2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		AP3M1	SIPA1L2
Description		adaptor related protein complex 3 subunit mu 1	signal induced proliferation associated 1 like 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Early Endosome Golgi Apparatus Membrane AP-3 Adaptor Complex Clathrin Adaptor Complex Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Postsynaptic Recycling Endosome Axon Cytoplasm	Cellular_component Cytoplasm Glutamatergic Synapse
	Molecular Function	Protein Binding Small GTPase Binding	GTPase Activator Activity Protein Binding
	Biological Process	Protein Targeting To Lysosome Intracellular Protein Transport Endocytosis Anterograde Axonal Transport Protein Transport Vesicle-mediated Transport Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Anterograde Synaptic Vesicle Transport Platelet Dense Granule Organization Postsynaptic Neurotransmitter Receptor Internalization Melanosome Assembly	Biological_process Regulation Of Small GTPase Mediated Signal Transduction Presynaptic Signal Transduction
Pathways		Association of TriC/CCT with target proteins during biosynthesis
Drugs
Diseases
GWAS		Cardiac troponin-I levels ( 31014085) Primary tooth development (number of teeth) ( 23704328) Primary tooth development (time to first tooth eruption) ( 23704328) Refractive error ( 32231278)	Age at first sexual intercourse ( 34211149) Alzheimer's disease ( 33074286) Bipolar disorder x sex interaction ( 34099189) Body size at age 10 ( 32376654) Immunoglobulin A ( 20694011) Parkinson's disease ( 25064009 28892059 32201043) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Post-traumatic stress disorder ( 24677629) PR interval ( 32439900) Reduced foot dorsiflexion strength in Charcot-Marie-Tooth disease type 1A ( 30706531) Schizophrenia ( 30285260) Smooth-surface caries ( 24556642)
Interacting Genes		14 interacting genes: AGTRAP AQP4 ARNT2 CRMP1 DVL3 IL36RN RUFY1 SIPA1L2 SLC12A4 SPAG16 TGOLN2 TRIM14 TRIM23 TRIM9	4 interacting genes: AP3M1 ORC5 TCEANC TGM2
Entrez ID		26985	57568
HPRD ID		16496	15346
Ensembl ID		ENSG00000185009	ENSG00000116991
Uniprot IDs		B4DRN6 Q9Y2T2	A0A6Q8PH54 Q9P2F8
PDB IDs		9C58 9C59 9C5A 9C5B 9C5C
Enriched GO Terms of Interacting Partners?		Cerebrospinal Fluid Circulation	Peptide Dopaminyltransferase Activity Histone Serotonyltransferase Activity Peptide Histaminyltransferase Activity Protein-glutamine Glutaminase Activity Peptide Noradrenalinyltransferase Activity Peptide Serotonyltransferase Activity Histone Dopaminyltransferase Activity Protein Deamination Nuclear Origin Of Replication Recognition Complex Origin Recognition Complex Dopamine Secretion Cellular Response To Dopamine Cellular Response To Serotonin Salivary Gland Cavitation Positive Regulation Of Mitochondrial Calcium Ion Concentration Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Response To Dopamine Protein-glutamine Gamma-glutamyltransferase Activity Catecholamine Secretion Postsynaptic Recycling Endosome Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Postsynaptic Neurotransmitter Receptor Internalization Regulation Of Apoptotic Cell Clearance Cellular Response To Cocaine AP-3 Adaptor Complex Branching Involved In Salivary Gland Morphogenesis Clathrin Adaptor Complex DNA Replication Origin Binding Endocytosis Peptide Cross-linking Cellular Response To Catecholamine Stimulus Anterograde Synaptic Vesicle Transport Melanosome Assembly Dopamine Transport Response To Catecholamine Mitochondrial Calcium Ion Homeostasis Endoplasmic Reticulum Calcium Ion Homeostasis Apoptotic Cell Clearance Platelet Dense Granule Organization DNA Replication Initiation Positive Regulation Of Sprouting Angiogenesis Monoamine Transport Protein Targeting To Lysosome Vesicle Cargo Loading Import Into Cell Cellular Response To Alkaloid Synaptic Vesicle Transport Melanosome Organization Chromosome Pigment Granule Organization
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