AP3M1 and TRIM9

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		AP3M1	TRIM9
Description		adaptor related protein complex 3 subunit mu 1	tripartite motif containing 9
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GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Early Endosome Golgi Apparatus Membrane AP-3 Adaptor Complex Clathrin Adaptor Complex Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Postsynaptic Recycling Endosome Axon Cytoplasm	Cytoplasm Cytoskeleton Synaptic Vesicle Dendrite Cytoplasmic Vesicle Cell Projection Synapse
	Molecular Function	Protein Binding Small GTPase Binding	Protein Binding Zinc Ion Binding Transferase Activity Protein Domain Specific Binding Protein Homodimerization Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Targeting To Lysosome Intracellular Protein Transport Endocytosis Anterograde Axonal Transport Protein Transport Vesicle-mediated Transport Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Anterograde Synaptic Vesicle Transport Platelet Dense Granule Organization Postsynaptic Neurotransmitter Receptor Internalization Melanosome Assembly	Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		Association of TriC/CCT with target proteins during biosynthesis	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Cardiac troponin-I levels ( 31014085) Primary tooth development (number of teeth) ( 23704328) Primary tooth development (time to first tooth eruption) ( 23704328) Refractive error ( 32231278)	Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Psychosis (atypical) ( 24132900) Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576) Urate levels (BMI interaction) ( 25811787)
Interacting Genes		14 interacting genes: AGTRAP AQP4 ARNT2 CRMP1 DVL3 IL36RN RUFY1 SIPA1L2 SLC12A4 SPAG16 TGOLN2 TRIM14 TRIM23 TRIM9	33 interacting genes: AP3M1 BTRC CHFR CSNK1D CWF19L2 DTNBP1 DTX3L EVL FAM124B FAM90A1 GFM2 LONRF1 MDM2 MNAT1 MUL1 NCF1 NFKBID NRIP1 NTAQ1 PCGF3 RNF166 RPL4P5 SHANK3 SNAP25 SPG21 TRIM27 TRIM46 TRIM8 TSSK3 USP2 USP21 UTP25 VASP
Entrez ID		26985	114088
HPRD ID		16496	05947
Ensembl ID		ENSG00000185009	ENSG00000100505
Uniprot IDs		B4DRN6 Q9Y2T2	A0A804HIL7 Q9C026
PDB IDs		9C58 9C59 9C5A 9C5B 9C5C	2DB8 7B2S
Enriched GO Terms of Interacting Partners?		Cerebrospinal Fluid Circulation	Protein Polyubiquitination Protein Destabilization Ubiquitin Protein Ligase Activity Post-translational Protein Modification Anterograde Synaptic Vesicle Transport Protein Modification Process Regulation Of Protein Stability SUMO Transferase Activity Positive Regulation Of Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Synaptic Vesicle Transport Establishment Of Vesicle Localization SH3 Domain Binding Vesicle Localization Vesicle Transport Along Microtubule Anterograde Axonal Transport Ubiquitin-protein Transferase Activity Protein Sumoylation Profilin Binding Vesicle Cytoskeletal Trafficking Protein Metabolic Process Zinc Ion Binding Axon Cytoplasm Axonal Transport Circadian Regulation Of Gene Expression Positive Regulation Of Autophagy BLOC-1 Complex Negative Regulation Of Cell Projection Organization Protein K63-linked Ubiquitination Negative Regulation Of Viral Transcription Suppression Of Viral Release By Host Axo-dendritic Transport Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Organelle Transport Along Microtubule Positive Regulation Of Proteolysis Regulation Of Viral Transcription Regulation Of Biological Quality Microtubule-based Transport Platelet Dense Granule Organization Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process PML Body Regulation Of Circadian Rhythm Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Neuron Projection Development Rhythmic Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Response To Formaldehyde
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