RIN3 and RAB5B

Number of citations of the paper that reports this interaction (PMID 12972505)
26

Data Source:
HPRD (two hybrid, in vitro)

		RIN3	RAB5B
Gene Name		Ras and Rab interactor 3	RAB5B, member RAS oncogene family
Image
Gene Ontology Annotations	Cellular Component	Early Endosome Cytoplasmic Membrane-bounded Vesicle Cytoplasmic Vesicle	Intracellular Endosome Early Endosome Plasma Membrane Membrane Endocytic Vesicle Early Endosome Membrane Melanosome Extracellular Vesicular Exosome
	Molecular Function	GTPase Activator Activity Protein Binding Rab Guanyl-nucleotide Exchange Factor Activity Rab GTPase Binding	GTPase Activity Protein Binding GTP Binding GDP Binding GTP-dependent Protein Binding
	Biological Process	Endocytosis Signal Transduction Positive Regulation Of Rab GTPase Activity	Intracellular Protein Transport Endosome Organization Antigen Processing And Presentation Regulation Of Endocytosis Rab Protein Signal Transduction Plasma Membrane To Endosome Transport
Pathways
Drugs
Diseases
GWAS		Dialysis-related mortality ( 21546767) Paget's disease ( 21623375)	Polycystic ovary syndrome ( 22885925) Type 1 diabetes ( 18198356) Vitiligo ( 22951725)
Protein-Protein Interactions		7 interactors: BIN1 RAB5A RAB5B RAB5C RABAC1 RGS2 TNFAIP1	15 interactors: APOA5 CDK1 CHM EEA1 RAB7A RABAC1 REEP5 RIN1 RIN2 RIN3 SGSM3 SUN2 TBC1D15 TBC1D17 TFRC
Entrez ID		79890	5869
HPRD ID		11494	01544
Ensembl ID		ENSG00000100599	ENSG00000111540
Uniprot IDs		Q86U22 Q8TB24	P61020
PDB IDs		3U23	2HEI
Enriched GO Terms of Interacting Partners?		Regulation Of Endocytosis Rab Protein Signal Transduction Regulation Of Vesicle-mediated Transport Plasma Membrane To Endosome Transport Endosomal Transport Ras Protein Signal Transduction Regulation Of Cellular Component Organization Vesicle-mediated Transport Small GTPase Mediated Signal Transduction Cytoplasmic Transport Lipid Tube Assembly Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Endosome Size Intracellular Protein Transport Regulation Of Adrenergic Receptor Signaling Pathway Positive Regulation Of Cardiac Muscle Contraction Negative Regulation Of CAMP-mediated Signaling Negative Regulation Of Phospholipase Activity Relaxation Of Vascular Smooth Muscle Positive Regulation Of Astrocyte Differentiation Relaxation Of Smooth Muscle Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Striated Muscle Contraction Negative Regulation Of Muscle Hypertrophy Cellular Protein Localization Positive Regulation Of Microtubule Polymerization Relaxation Of Cardiac Muscle Stress Fiber Assembly Protein Transport Negative Regulation Of Smooth Muscle Contraction Establishment Of Protein Localization Negative Regulation Of Intracellular Signal Transduction Protein-lipid Complex Assembly Intracellular Transport Negative Regulation Of Lipase Activity Early Endosome To Late Endosome Transport Negative Regulation Of Muscle Contraction Regulation Of CAMP-mediated Signaling Relaxation Of Muscle Negative Regulation Of Rho Protein Signal Transduction Positive Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Heart Contraction Regulation Of Microtubule Polymerization Regulation Of Astrocyte Differentiation Endosome Organization Regulation Of Cardiac Muscle Hypertrophy Regulation Of Long-term Neuronal Synaptic Plasticity Intracellular Signal Transduction Regulation Of Synaptic Vesicle Exocytosis Vasodilation	Positive Regulation Of Rab GTPase Activity Regulation Of Rab GTPase Activity Regulation Of Rab Protein Signal Transduction Positive Regulation Of Catalytic Activity Positive Regulation Of Hydrolase Activity Positive Regulation Of GTPase Activity Regulation Of GTPase Activity Vesicle-mediated Transport Endocytosis Regulation Of Catalytic Activity Positive Regulation Of Ras GTPase Activity Endosomal Transport Regulation Of Ras GTPase Activity Organelle Fusion Regulation Of Ras Protein Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Small GTPase Mediated Signal Transduction Transport Early Endosome To Late Endosome Transport Membrane Organization Regulation Of Signaling Cellular Localization Ras Protein Signal Transduction Regulation Of Intracellular Signal Transduction Small GTPase Mediated Signal Transduction Vesicle Fusion Protein Localization Regulation Of Signal Transduction Establishment Of Localization In Cell Synaptic Vesicle To Endosome Fusion Pronuclear Fusion Epidermal Growth Factor Catabolic Process Retrograde Transport, Endosome To Golgi Nuclear Envelope Organization Organ Regeneration Positive Regulation Of Very-low-density Lipoprotein Particle Remodeling Intracellular Transport Nuclear Matrix Organization Negative Regulation Of Synaptic Plasticity Nuclear Matrix Anchoring At Nuclear Membrane Nucleus Organization Phagosome-lysosome Fusion Nuclear Migration Along Microfilament Regulation Of Metabolic Process Membrane Fusion Phagosome Acidification Protein Localization To Organelle Regulation Of Schwann Cell Differentiation Protein Geranylgeranylation Protein To Membrane Docking
Tagcloud ?		abca7 bin1 cass4 cd2ap cd33 celf1 chapter discoveries drb1 drb5 epha1 fermt2 inpp5d mef2c ms4a4 ms4a6 nme8 picalm pld3 psen1 psen2 ptk2b slc24a4 sorl1 touch trem2 trip4 unsuspected zcwpw1
Tagcloud (Difference) ?		abca7 bin1 cass4 cd2ap cd33 celf1 chapter discoveries drb1 drb5 epha1 fermt2 inpp5d mef2c ms4a4 ms4a6 nme8 picalm pld3 psen1 psen2 ptk2b slc24a4 sorl1 touch trem2 trip4 unsuspected zcwpw1
Tagcloud (Intersection) ?