RIN3 and MPEG1

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		RIN3	MPEG1
Description		Ras and Rab interactor 3	macrophage expressed 1
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GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Cytosol Endocytic Vesicle Axon Dendrite Cytoplasmic Vesicle Vesicle Neuronal Cell Body	Extracellular Region Membrane Cytoplasmic Vesicle Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Phagocytic Vesicle Phagolysosome Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding	Wide Pore Channel Activity
	Biological Process	Negative Regulation Of Receptor Internalization Endocytosis Signal Transduction Vesicle-mediated Transport Negative Regulation Of Mast Cell Chemotaxis Regulation Of Vesicle Size	Adaptive Immune Response Immune System Process Dendritic Cell Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Defense Response To Bacterium Innate Immune Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Transmembrane Transport Antibacterial Innate Immune Response
Pathways		RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 24162737 30617256) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Appendicular lean mass ( 33097823) Asthma ( 32296059) Bone mineral density (paediatric, lower limb) ( 24945404) Bone mineral density (paediatric, total body less head) ( 24945404) Breast cancer ( 29059683 25751625) Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682) Chronic obstructive pulmonary disease ( 28166215 30804561 25101718 33909500) Chronic obstructive pulmonary disease (moderate to severe) ( 24621683) Chronic obstructive pulmonary disease (severe) ( 24621683) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Composite immunoglobulin trait (IgA/IgM) ( 28628107) Dialysis-related mortality ( 21546767) Eosinophil count ( 32888494 27863252) Eosinophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 31152163) FEV1 ( 30804560) Granulocyte count ( 27863252) Hip index ( 34021172) Local histogram emphysema pattern ( 25006744) Lung function (FEV1) ( 26635082) Lung function (FVC) ( 30804560 26635082) Lymphocyte percentage of white cells ( 32888494 27863252) Mean platelet volume ( 32888494) Monocyte count ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Paget's disease ( 21623375) Platelet distribution width ( 32888494) Plateletcrit ( 27863252 32888494) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Proximal colorectal cancer ( 33632709) Pulse pressure ( 30224653) Sepsis (28-day mortality) ( 32592749) Serum alkaline phosphatase levels ( 33547301) Sum basophil neutrophil counts ( 27863252) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic juvenile idiopathic arthritis ( 27927641) White blood cell count ( 32888494 27863252)	Hepatitis B surface antigen seroclearance in chronic hepatitis B infection ( 29975729)
Interacting Genes		40 interacting genes: ASB3 ASB8 BIN1 CD2AP CSRP3 CYP2C8 CYP46A1 DOK3 EPS8L2 EZH2 GATA1 GRAP2 ID2 KCTD17 LCK MPEG1 MT2A PLB1 POLR3F PSMD9 RAB5A RAB5B RAB5C RABAC1 RGS2 RTL8B SPATA12 SPRY4 SUV39H1 SYMPK TENT5A TGM1 TM4SF19 TNFAIP1 TSC1 TSSK3 ZBTB24 ZNF639 ZNF655 ZNF71	2 interacting genes: RIN3 TNS2
Entrez ID		79890	219972
HPRD ID		11494	19311
Ensembl ID		ENSG00000100599	ENSG00000197629
Uniprot IDs		Q6NSK7 Q6ZRC2 Q86U22 Q8TB24	Q2M385
PDB IDs		3U23 4WCI	6U23 6U2J 6U2K 6U2L 6U2W
Enriched GO Terms of Interacting Partners?		Plasma Membrane To Endosome Transport	Negative Regulation Of Mast Cell Chemotaxis
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