RIN3 and RGS2

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		RIN3	RGS2
Gene Name		Ras and Rab interactor 3	regulator of G-protein signaling 2
Image
Gene Ontology Annotations	Cellular Component	Early Endosome Cytoplasmic Membrane-bounded Vesicle Cytoplasmic Vesicle	Nucleolus Cytoplasm Mitochondrion Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Neuron Projection
	Molecular Function	GTPase Activator Activity Protein Binding Rab Guanyl-nucleotide Exchange Factor Activity Rab GTPase Binding	GTPase Activator Activity Protein Binding Calmodulin Binding Beta-tubulin Binding
	Biological Process	Endocytosis Signal Transduction Positive Regulation Of Rab GTPase Activity	Regulation Of Translation Cell Cycle Spermatogenesis Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Phospholipase Activity Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Microtubule Polymerization Termination Of G-protein Coupled Receptor Signaling Pathway Negative Regulation Of MAP Kinase Activity Positive Regulation Of GTPase Activity Negative Regulation Of CAMP-mediated Signaling Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Brown Fat Cell Differentiation Relaxation Of Cardiac Muscle Relaxation Of Vascular Smooth Muscle Positive Regulation Of Cardiac Muscle Contraction Regulation Of Adrenergic Receptor Signaling Pathway
Pathways			G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK
Drugs
Diseases
GWAS		Dialysis-related mortality ( 21546767) Paget's disease ( 21623375)
Protein-Protein Interactions		7 interactors: BIN1 RAB5A RAB5B RAB5C RABAC1 RGS2 TNFAIP1	58 interactors: ADCY5 ADRA1A ADRB2 ARFGAP1 BBS10 CALM1 CHD3 CLTA COMT COPB1 COPB2 CRMP1 CTSB DDR1 DUSP21 DYNLL1 EIF3L FZD5 GDE1 GIT1 GNA15 GNAI3 GNAQ GNAS HAUS5 HSPA8 IER3IP1 KIAA1377 KLK8 LIG1 LRFN1 METTL18 MON1A MTUS2 NINL NIPSNAP1 PARK2 PPP1R9B PRKCA PRKCB PRKCG PRKCSH PRKG1 RAB2A RABAC1 RAP1B REEP5 RIN3 SCN5A TSPAN15 TUBB2B UBC VPS29 WDR74 XRCC6 ZBTB48 ZNF579 ZYX
Entrez ID		79890	5997
HPRD ID		11494	02917
Ensembl ID		ENSG00000100599	ENSG00000116741
Uniprot IDs		Q86U22 Q8TB24	P41220
PDB IDs		3U23	2AF0 2V4Z 4EKC 4EKD
Enriched GO Terms of Interacting Partners?		Regulation Of Endocytosis Rab Protein Signal Transduction Regulation Of Vesicle-mediated Transport Plasma Membrane To Endosome Transport Endosomal Transport Ras Protein Signal Transduction Regulation Of Cellular Component Organization Vesicle-mediated Transport Small GTPase Mediated Signal Transduction Cytoplasmic Transport Lipid Tube Assembly Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Endosome Size Intracellular Protein Transport Regulation Of Adrenergic Receptor Signaling Pathway Positive Regulation Of Cardiac Muscle Contraction Negative Regulation Of CAMP-mediated Signaling Negative Regulation Of Phospholipase Activity Relaxation Of Vascular Smooth Muscle Positive Regulation Of Astrocyte Differentiation Relaxation Of Smooth Muscle Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Striated Muscle Contraction Negative Regulation Of Muscle Hypertrophy Cellular Protein Localization Positive Regulation Of Microtubule Polymerization Relaxation Of Cardiac Muscle Stress Fiber Assembly Protein Transport Negative Regulation Of Smooth Muscle Contraction Establishment Of Protein Localization Negative Regulation Of Intracellular Signal Transduction Protein-lipid Complex Assembly Intracellular Transport Negative Regulation Of Lipase Activity Early Endosome To Late Endosome Transport Negative Regulation Of Muscle Contraction Regulation Of CAMP-mediated Signaling Relaxation Of Muscle Negative Regulation Of Rho Protein Signal Transduction Positive Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Heart Contraction Regulation Of Microtubule Polymerization Regulation Of Astrocyte Differentiation Endosome Organization Regulation Of Cardiac Muscle Hypertrophy Regulation Of Long-term Neuronal Synaptic Plasticity Intracellular Signal Transduction Regulation Of Synaptic Vesicle Exocytosis Vasodilation	Activation Of Phospholipase C Activity Positive Regulation Of Phospholipase C Activity Positive Regulation Of Phospholipase Activity Platelet Activation Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Regulation Of Catalytic Activity Regulation Of Body Fluid Levels Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Response To Wounding Blood Coagulation G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Hemostasis Wound Healing Cell-cell Signaling Regulation Of Phosphorus Metabolic Process Regulation Of Adenylate Cyclase Activity Nervous System Development Regulation Of Cyclase Activity Activation Of Adenylate Cyclase Activity Signaling Response To Stress Neurotrophin Signaling Pathway Cell Communication Regulation Of Phosphorylation Dopamine Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Developmental Process Positive Regulation Of Adenylate Cyclase Activity Regulation Of Kinase Activity Response To Organic Substance Cellular Response To Stimulus Regulation Of Muscle Contraction Anatomical Structure Development Regulation Of CAMP Biosynthetic Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Positive Regulation Of Hydrolase Activity Cell Activation Membrane Organization Regulation Of CAMP Metabolic Process Regulation Of Protein Phosphorylation System Development Positive Regulation Of Lyase Activity Enzyme Linked Receptor Protein Signaling Pathway Golgi Vesicle Budding Adrenergic Receptor Signaling Pathway
Tagcloud ?		abca7 bin1 cass4 cd2ap cd33 celf1 chapter discoveries drb1 drb5 epha1 fermt2 inpp5d mef2c ms4a4 ms4a6 nme8 picalm pld3 psen1 psen2 ptk2b slc24a4 sorl1 touch trem2 trip4 unsuspected zcwpw1	3t3 adipocyte already arrested beginning cloned clones differentially earliest ebpalpha hif hsp105 inducers l1 master mrnas nih nineteen place ppargamma2 preadipocyte proliferating regulators rho seemed steps takes tc10 vdr
Tagcloud (Difference) ?		abca7 bin1 cass4 cd2ap cd33 celf1 chapter discoveries drb1 drb5 epha1 fermt2 inpp5d mef2c ms4a4 ms4a6 nme8 picalm pld3 psen1 psen2 ptk2b slc24a4 sorl1 touch trem2 trip4 unsuspected zcwpw1	3t3 adipocyte already arrested beginning cloned clones differentially earliest ebpalpha hif hsp105 inducers l1 master mrnas nih nineteen place ppargamma2 preadipocyte proliferating regulators rho seemed steps takes tc10 vdr
Tagcloud (Intersection) ?