RIN3 and TNFAIP1

Number of citations of the paper that reports this interaction (PMID 22810651)
2

Data Source:
BioGRID (two hybrid)

		RIN3	TNFAIP1
Gene Name		Ras and Rab interactor 3	tumor necrosis factor, alpha-induced protein 1 (endothelial)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Early Endosome Cytoplasmic Membrane-bounded Vesicle Cytoplasmic Vesicle	Nucleolus Cytoplasm Endosome Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	GTPase Activator Activity Protein Binding Rab Guanyl-nucleotide Exchange Factor Activity Rab GTPase Binding	Ubiquitin-protein Transferase Activity Protein Binding GTP-Rho Binding Protein Domain Specific Binding
	Biological Process	Endocytosis Signal Transduction Positive Regulation Of Rab GTPase Activity	DNA Replication Apoptotic Process Immune Response Embryo Development Cell Migration Protein Ubiquitination Negative Regulation Of Rho Protein Signal Transduction Stress Fiber Assembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Replication Protein Homooligomerization
Pathways
Drugs
Diseases
GWAS		Dialysis-related mortality ( 21546767) Paget's disease ( 21623375)
Protein-Protein Interactions		7 interactors: BIN1 RAB5A RAB5B RAB5C RABAC1 RGS2 TNFAIP1	21 interactors: ARMC7 ARNT CAPN7 CARD9 CSNK2B CUL3 EPHA2 EPM2AIP1 EXOSC5 HAT1 KCTD13 KDM1A POLR1C PSMA1 RHOA RHOB RIN3 STK16 SUV39H1 SVIL ZDHHC17
Entrez ID		79890	7126
HPRD ID		11494	01856
Ensembl ID		ENSG00000100599	ENSG00000109079
Uniprot IDs		Q86U22 Q8TB24	Q13829
PDB IDs		3U23
Enriched GO Terms of Interacting Partners?		Regulation Of Endocytosis Rab Protein Signal Transduction Regulation Of Vesicle-mediated Transport Plasma Membrane To Endosome Transport Endosomal Transport Ras Protein Signal Transduction Regulation Of Cellular Component Organization Vesicle-mediated Transport Small GTPase Mediated Signal Transduction Cytoplasmic Transport Lipid Tube Assembly Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Endosome Size Intracellular Protein Transport Regulation Of Adrenergic Receptor Signaling Pathway Positive Regulation Of Cardiac Muscle Contraction Negative Regulation Of CAMP-mediated Signaling Negative Regulation Of Phospholipase Activity Relaxation Of Vascular Smooth Muscle Positive Regulation Of Astrocyte Differentiation Relaxation Of Smooth Muscle Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Striated Muscle Contraction Negative Regulation Of Muscle Hypertrophy Cellular Protein Localization Positive Regulation Of Microtubule Polymerization Relaxation Of Cardiac Muscle Stress Fiber Assembly Protein Transport Negative Regulation Of Smooth Muscle Contraction Establishment Of Protein Localization Negative Regulation Of Intracellular Signal Transduction Protein-lipid Complex Assembly Intracellular Transport Negative Regulation Of Lipase Activity Early Endosome To Late Endosome Transport Negative Regulation Of Muscle Contraction Regulation Of CAMP-mediated Signaling Relaxation Of Muscle Negative Regulation Of Rho Protein Signal Transduction Positive Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Heart Contraction Regulation Of Microtubule Polymerization Regulation Of Astrocyte Differentiation Endosome Organization Regulation Of Cardiac Muscle Hypertrophy Regulation Of Long-term Neuronal Synaptic Plasticity Intracellular Signal Transduction Regulation Of Synaptic Vesicle Exocytosis Vasodilation	Regulation Of Signal Transduction Regulation Of Signaling Response To Stimulus Regulation Of Intracellular Signal Transduction Positive Regulation Of Cytokinesis Regulation Of Cytokinesis Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Cell Cycle Process Positive Regulation Of Hormone Biosynthetic Process Stress Fiber Assembly Positive Regulation Of Cell Cycle Cellular Protein Modification Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Cell Division Response To Stress Negative Regulation Of Rho Protein Signal Transduction Regulation Of Cellular Process Regulation Of Hormone Biosynthetic Process Regulation Of Epithelial Cell Migration Cell Morphogenesis Involved In Differentiation Axon Guidance Negative Regulation Of Intracellular Signal Transduction Chromatin Silencing Regulation Of Hormone Metabolic Process Locomotion Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Erythrocyte Differentiation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To External Stimulus Cell Cycle Regulation Of Cell Cycle Process Regulation Of Gene Expression, Epigenetic Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cell Cycle Axonogenesis Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Primitive Erythrocyte Differentiation Notochord Cell Development Viral Process Movement Of Cell Or Subcellular Component Axon Development Rho Protein Signal Transduction Cellular Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ras Protein Signal Transduction Regulation Of Cell Division
Tagcloud ?		abca7 bin1 cass4 cd2ap cd33 celf1 chapter discoveries drb1 drb5 epha1 fermt2 inpp5d mef2c ms4a4 ms4a6 nme8 picalm pld3 psen1 psen2 ptk2b slc24a4 sorl1 touch trem2 trip4 unsuspected zcwpw1	adjacent ancts cancerous collectively concerning cytometric distant downregulation experiment immunohistochemical inducible invasion knockdown lentiviral metalloproteinase metastases metastasis microarray mmp mtt os osteosarcoma p65 pcna proliferating sirna transwell upregulation
Tagcloud (Difference) ?		abca7 bin1 cass4 cd2ap cd33 celf1 chapter discoveries drb1 drb5 epha1 fermt2 inpp5d mef2c ms4a4 ms4a6 nme8 picalm pld3 psen1 psen2 ptk2b slc24a4 sorl1 touch trem2 trip4 unsuspected zcwpw1	adjacent ancts cancerous collectively concerning cytometric distant downregulation experiment immunohistochemical inducible invasion knockdown lentiviral metalloproteinase metastases metastasis microarray mmp mtt os osteosarcoma p65 pcna proliferating sirna transwell upregulation
Tagcloud (Intersection) ?