RIN3

Gene Name		Ras and Rab interactor 3
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Gene Ontology Annotations	Cellular Component	Early Endosome Cytoplasmic Membrane-bounded Vesicle Cytoplasmic Vesicle
	Molecular Function	GTPase Activator Activity Protein Binding Rab Guanyl-nucleotide Exchange Factor Activity Rab GTPase Binding
	Biological Process	Endocytosis Signal Transduction Positive Regulation Of Rab GTPase Activity
Pathways
Drugs
Diseases
GWAS		Dialysis-related mortality ( 21546767) Paget's disease ( 21623375)
Protein-protein Interactions		7 interactors: BIN1 RAB5A RAB5B RAB5C RABAC1 RGS2 TNFAIP1
Entrez ID		79890
HPRD ID		11494
Ensembl ID		ENSG00000100599
Uniprot IDs		Q86U22 Q8TB24
PDB IDs		3U23
Enriched GO Terms of Interacting Partners?		Regulation Of Endocytosis Rab Protein Signal Transduction Regulation Of Vesicle-mediated Transport Plasma Membrane To Endosome Transport Endosomal Transport Ras Protein Signal Transduction Regulation Of Cellular Component Organization Vesicle-mediated Transport Small GTPase Mediated Signal Transduction Cytoplasmic Transport Lipid Tube Assembly Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Endosome Size Intracellular Protein Transport Regulation Of Adrenergic Receptor Signaling Pathway Positive Regulation Of Cardiac Muscle Contraction Negative Regulation Of CAMP-mediated Signaling Negative Regulation Of Phospholipase Activity Relaxation Of Vascular Smooth Muscle Positive Regulation Of Astrocyte Differentiation Relaxation Of Smooth Muscle Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Striated Muscle Contraction Negative Regulation Of Muscle Hypertrophy Cellular Protein Localization Positive Regulation Of Microtubule Polymerization Relaxation Of Cardiac Muscle Stress Fiber Assembly Protein Transport Negative Regulation Of Smooth Muscle Contraction Establishment Of Protein Localization Negative Regulation Of Intracellular Signal Transduction Protein-lipid Complex Assembly Intracellular Transport Negative Regulation Of Lipase Activity Early Endosome To Late Endosome Transport Negative Regulation Of Muscle Contraction Regulation Of CAMP-mediated Signaling Relaxation Of Muscle Negative Regulation Of Rho Protein Signal Transduction Positive Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Heart Contraction Regulation Of Microtubule Polymerization Regulation Of Astrocyte Differentiation Endosome Organization Regulation Of Cardiac Muscle Hypertrophy Regulation Of Long-term Neuronal Synaptic Plasticity Intracellular Signal Transduction Regulation Of Synaptic Vesicle Exocytosis Vasodilation
Tagcloud ?		abca7 bin1 cass4 cd2ap cd33 celf1 chapter discoveries drb1 drb5 epha1 fermt2 inpp5d mef2c ms4a4 ms4a6 nme8 picalm pld3 psen1 psen2 ptk2b slc24a4 sorl1 touch trem2 trip4 unsuspected zcwpw1