SPRYD7 and HEMK1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SPRYD7	HEMK1
Description		SPRY domain containing 7	HemK methyltransferase 1, mitochondrial release factors N(5)-glutamine
Image			No pdb structure
GO Annotations	Cellular Component		Mitochondrion
	Molecular Function	Protein Binding	Nucleic Acid Binding DNA Binding Protein Binding Methyltransferase Activity N-methyltransferase Activity Protein Methyltransferase Activity S-adenosylmethionine-dependent Methyltransferase Activity Transferase Activity Protein-glutamine N-methyltransferase Activity Peptide Chain Release Factor N(5)-glutamine Methyltransferase Activity
	Biological Process		Translational Termination Methylation
Pathways
Drugs
Diseases
GWAS		Waist-to-hip ratio adjusted for body mass index ( 28430825)	Appendicular lean mass ( 33097823) Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025) Cocaine dependence ( 31212010) Depressive symptom (appetite changes) (binary trait) ( 31530331) Depressive symptoms (binary sum-score) ( 31530331) Depressive symptoms (sum-score) ( 31530331) Height ( 28552196)
Interacting Genes		15 interacting genes: AGXT AQP1 CAMK2B HEMK1 NHERF4 NTAQ1 OTX1 POGZ TLX3 TRIM55 TRIM63 TRIP13 UBASH3A VAC14 YPEL3	18 interacting genes: AKAP8L ASCL3 CDC23 CHN1 CTAG1A CTAG1B HEATR9 INCA1 KRTAP19-1 MAGED1 PEF1 POU2AF1 PSMB4 SHOX SOHLH1 SPRYD7 TUBGCP5 UBQLN2
Entrez ID		57213	51409
HPRD ID		08486	13645
Ensembl ID		ENSG00000123178	ENSG00000114735
Uniprot IDs		A0A024RDT6 Q5W111	A0A140VK98 B2RA37 Q9Y5R4
PDB IDs		7CCB
Enriched GO Terms of Interacting Partners?		L-serine-pyruvate Transaminase Activity Metanephric Descending Thin Limb Development Metanephric Proximal Straight Tubule Development Fluid Transport Nitric Oxide Transmembrane Transporter Activity Metanephric Proximal Convoluted Tubule Segment 2 Development Water Transport Diencephalon Morphogenesis Protein-glutamine N-methyltransferase Activity Peptide Chain Release Factor N(5)-glutamine Methyltransferase Activity Protein-N-terminal Glutamine Amidohydrolase Activity PAS Complex Guanylate Cyclase Inhibitor Activity
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