GNMT and GABRQ

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		GNMT	GABRQ
Name		glycine N-methyltransferase	gamma-aminobutyric acid type A receptor subunit theta
Structure			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Plasma Membrane Membrane Chloride Channel Complex Receptor Complex Synapse Postsynaptic Membrane GABA-A Receptor Complex
	Molecular Function	Protein Binding Folic Acid Binding Methyltransferase Activity Glycine Binding Transferase Activity Glycine N-methyltransferase Activity Identical Protein Binding S-adenosyl-L-methionine Binding	Transmembrane Signaling Receptor Activity GABA-A Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Chloride Channel Activity Neurotransmitter Transmembrane Transporter Activity Protein Binding GABA-gated Chloride Ion Channel Activity
	Biological Process	Glycogen Metabolic Process Regulation Of Gluconeogenesis Methionine Metabolic Process One-carbon Metabolic Process Methylation S-adenosylhomocysteine Metabolic Process S-adenosylmethionine Metabolic Process Protein Homotetramerization Sarcosine Metabolic Process	Monoatomic Ion Transport Chloride Transport Neurotransmitter Transport Signal Transduction Monoatomic Ion Transmembrane Transport Synaptic Transmission, GABAergic Chloride Transmembrane Transport
Pathways		Metabolism of ingested SeMet, Sec, MeSec into H2Se Glyoxylate metabolism and glycine degradation Developmental Lineage of Pancreatic Acinar Cells	Signaling by ERBB4 GABA receptor activation GABA receptor activation
Drugs		Ademetionine Glycine S-adenosyl-L-homocysteine	Lorazepam Ethchlorvynol Enflurane Temazepam Butabarbital Butalbital Phenytoin Etomidate Talbutal Pentobarbital Clobazam Meprobamate Eszopiclone Alprazolam Metharbital Chlordiazepoxide Amoxapine Adinazolam Lamotrigine Medroxyprogesterone acetate Clorazepic acid Midazolam Flurazepam Isoflurane Primidone Halazepam Propofol Diazepam Oxazepam Triazolam Ethanol Methoxyflurane Memantine Clonazepam Methyprylon Halothane Desflurane Flumazenil Estazolam Sevoflurane Glutethimide Camazepam Delorazepam Flunitrazepam Ethyl loflazepate Cloxazolam Bromazepam Clotiazepam Ketazolam Prazepam Quazepam Cinolazepam Nitrazepam Prasterone Taurine Ganaxolone Brotizolam Stiripentol Etizolam Thiocolchicoside Brexanolone Apalutamide Remimazolam 1,2-Benzodiazepine Pinazepam Medazepam Loprazolam Doxefazepam Lormetazepam Nordazepam Oxazepam acetate Cinazepam Bentazepam Mexazolam
Diseases		Hypermethioninemia; Methionine adenosyltransferase deficiency; S-adenosylhomocysteine hydrolase deficiency	None
GWAS		Apolipoprotein B levels ( 32203549 ) Blood protein levels ( 30072576 ) LDL cholesterol levels ( 32203549 ) Plasma homocysteine levels (post-methionine load test) ( 24651765 )	No GWAS studies recorded
Novel Interactors		1 novel interactors: STT3B	1 novel interactors: DYNLL1
Interacting Genes		31 interacting genes: ADAMTSL4 ARR3 ARRB1 COX7B CTNS DRC12 FRG1 GABRQ GAGE2A HDAC7 HPRT1 KRTAP10-3 KRTAP4-2 NIF3L1 NOTCH2NLA NTAQ1 NUDT18 OTOS PLEKHF2 POT1 PRKACA RPSA SDCBP SNRNP200 SRD5A2 TERF1 TERF2 TERF2IP TINF2 TRIM35 ZNF337	1 interacting genes: GNMT
Entrez ID		27232	55879
HPRD ID		05970	02284
Ensembl ID		ENSG00000124713	ENSG00000268089
Uniprot IDs		A0A0S2Z5F2 Q14749 V9HW60	Q9UN88
PDB IDs		1R74 2AZT	Not available
GO Terms Enriched among Interactors		Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Telomeric DNA Binding G-rich Strand Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Chromosome Organization Telomeric D-loop Disassembly Telomeric Loop Disassembly Protein Localization To Chromosome, Telomeric Region Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of DNA Recombination At Telomere Telomere Organization Negative Regulation Of DNA Metabolic Process Telomere Maintenance Via Telomerase Chromosome, Telomeric Region Regulation Of DNA Biosynthetic Process Telomere Assembly DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Telomerase Activity Protection From Non-homologous End Joining At Telomere Regulation Of Chromosome Organization Double-stranded Telomeric DNA Binding Positive Regulation Of DNA Metabolic Process G Protein-coupled Receptor Internalization Telomere Maintenance In Response To DNA Damage Positive Regulation Of Organelle Organization Grooming Behavior Chromosome Organization Nuclear Body Positive Regulation Of Cellular Component Organization Negative Regulation Of Interleukin-2 Production Protein Localization To Chromosome Striated Muscle Dense Body Guanine Phosphoribosyltransferase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Component Organization Interleukin-5 Receptor Complex	Deoxyribonuclease Inhibitor Activity Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Regulation Of DNA Strand Resection Involved In Replication Fork Processing Nitric-oxide Synthase Inhibitor Activity Sarcosine Metabolic Process Glycine N-methyltransferase Activity S-adenosylhomocysteine Metabolic Process Nitric-oxide Synthase Regulator Activity Negative Regulation Of DNA-templated DNA Replication Glycine Binding Folic Acid Binding S-adenosylmethionine Metabolic Process Negative Regulation Of Nitric Oxide Biosynthetic Process Intraciliary Retrograde Transport DNA Strand Resection Involved In Replication Fork Processing Methionine Metabolic Process Cytoplasmic Dynein Complex One-carbon Metabolic Process S-adenosyl-L-methionine Binding Negative Regulation Of DNA Replication Purine Nucleoside Metabolic Process Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus COP9 Signalosome Dynein Intermediate Chain Binding Dynein Complex Microtubule Associated Complex Sulfur Amino Acid Metabolic Process Ciliary Tip Substantia Nigra Development Motile Cilium Assembly Intraciliary Transport Aspartate Family Amino Acid Metabolic Process Nucleoside Metabolic Process Enzyme Inhibitor Activity Ficolin-1-rich Granule Membrane Neural Nucleus Development Regulation Of Nitric Oxide Metabolic Process Axon Cytoplasm Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Nitric Oxide Biosynthetic Process Tertiary Granule Membrane Glycogen Metabolic Process Regulation Of Gluconeogenesis Protein Homotetramerization Scaffold Protein Binding Energy Reserve Metabolic Process Polysaccharide Metabolic Process Positive Regulation Of Insulin Secretion Identical Protein Binding Protein Tetramerization