GNMT and SRD5A2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GNMT	SRD5A2
Description		glycine N-methyltransferase	steroid 5 alpha-reductase 2
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GO Annotations	Cellular Component	Cytoplasm Cytosol	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Neuronal Cell Body Cell Body Fiber
	Molecular Function	Protein Binding Folic Acid Binding Methyltransferase Activity Glycine Binding Transferase Activity Glycine N-methyltransferase Activity Identical Protein Binding S-adenosyl-L-methionine Binding	3-oxo-5-alpha-steroid 4-dehydrogenase Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors Amide Binding 3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) Activity
	Biological Process	Glycogen Metabolic Process Regulation Of Gluconeogenesis Methionine Metabolic Process One-carbon Metabolic Process Methylation S-adenosylhomocysteine Metabolic Process S-adenosylmethionine Metabolic Process Protein Homotetramerization Sarcosine Metabolic Process	Lipid Metabolic Process Steroid Biosynthetic Process Androgen Biosynthetic Process Steroid Catabolic Process Cell-cell Signaling Sex Differentiation Steroid Metabolic Process Androgen Metabolic Process Male Gonad Development Response To Xenobiotic Stimulus Biphenyl Metabolic Process Dibenzo-p-dioxin Metabolic Process Phthalate Metabolic Process Hippocampus Development Hypothalamus Development Cell Differentiation Male Genitalia Development Female Genitalia Development Response To Nutrient Levels Response To Follicle-stimulating Hormone Response To Testosterone Response To Peptide Hormone Response To Steroid Hormone Bone Development Testosterone Biosynthetic Process Response To Biphenyl
Pathways		Metabolism of ingested SeMet, Sec, MeSec into H2Se Glyoxylate metabolism and glycine degradation Developmental Lineage of Pancreatic Acinar Cells	Androgen biosynthesis
Drugs		Ademetionine Glycine S-adenosyl-L-homocysteine	Spironolactone Azelaic acid Dutasteride Finasteride
Diseases		Hypermethioninemia; Methionine adenosyltransferase deficiency; S-adenosylhomocysteine hydrolase deficiency	46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenital adrenal hyperplasias; Leydig cell hypoplasia; Androgen insensitivity syndrome (AIS)
GWAS		Apolipoprotein B levels ( 32203549) Blood protein levels ( 30072576) LDL cholesterol levels ( 32203549) Plasma homocysteine levels (post-methionine load test) ( 24651765)	Estradiol levels ( 34255042) Idiopathic pulmonary fibrosis ( 29066090) Inflammatory biomarkers ( 24182552) Male-pattern baldness ( 27182965 28196072 29146897) Zinc levels ( 26025379)
Interacting Genes		31 interacting genes: ADAMTSL4 ARR3 ARRB1 COX7B CTNS DRC12 FRG1 GABRQ GAGE2A HDAC7 HPRT1 KRTAP10-3 KRTAP4-2 NIF3L1 NOTCH2NLA NTAQ1 NUDT18 OTOS PLEKHF2 POT1 PRKACA RPSA SDCBP SNRNP200 SRD5A2 TERF1 TERF2 TERF2IP TINF2 TRIM35 ZNF337	2 interacting genes: CYSRT1 GNMT
Entrez ID		27232	6716
HPRD ID		05970	07390
Ensembl ID		ENSG00000124713	ENSG00000277893
Uniprot IDs		A0A0S2Z5F2 Q14749 V9HW60	P31213
PDB IDs		1R74 2AZT	7BW1
Enriched GO Terms of Interacting Partners?		Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Telomeric DNA Binding G-rich Strand Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Chromosome Organization Telomeric D-loop Disassembly Telomeric Loop Disassembly Protein Localization To Chromosome, Telomeric Region Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of DNA Recombination At Telomere Telomere Organization Negative Regulation Of DNA Metabolic Process Telomere Maintenance Via Telomerase Chromosome, Telomeric Region Regulation Of DNA Biosynthetic Process Telomere Assembly DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Telomerase Activity Protection From Non-homologous End Joining At Telomere Regulation Of Chromosome Organization Double-stranded Telomeric DNA Binding Positive Regulation Of DNA Metabolic Process G Protein-coupled Receptor Internalization Telomere Maintenance In Response To DNA Damage Positive Regulation Of Organelle Organization Grooming Behavior Chromosome Organization Nuclear Body Positive Regulation Of Cellular Component Organization Negative Regulation Of Interleukin-2 Production Protein Localization To Chromosome Striated Muscle Dense Body Guanine Phosphoribosyltransferase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Component Organization Interleukin-5 Receptor Complex	Positive Regulation Of Transcription From RNA Polymerase II Promoter By Galactose Glycine N-methyltransferase Activity Labyrinthine Layer Morphogenesis Sarcosine Metabolic Process S-adenosylhomocysteine Metabolic Process Cellular Response To Thyroglobulin Triiodothyronine Positive Regulation Of Female Receptivity Response To Thyroglobulin Triiodothyronine Regulation Of Thyroid Hormone Receptor Signaling Pathway Male Mating Behavior Carbon Catabolite Regulation Of Transcription Regulation Of Female Receptivity Female Mating Behavior Glycine Binding Folic Acid Binding Estrous Cycle S-adenosylmethionine Metabolic Process Peroxisome Proliferator Activated Receptor Signaling Pathway Progesterone Receptor Signaling Pathway Positive Regulation Of Adipose Tissue Development Hypothalamus Development Nuclear Retinoic Acid Receptor Binding Proton-transporting ATP Synthase Activity, Rotational Mechanism Methionine Metabolic Process Nuclear Retinoid X Receptor Binding Regulation Of Adipose Tissue Development Mating Behavior Ovulation Cycle Purine-containing Compound Metabolic Process Proton-transporting ATP Synthase Complex S-adenosyl-L-methionine Binding Estrogen Receptor Signaling Pathway One-carbon Metabolic Process Protein-lysine-acetyltransferase Activity Proton Transmembrane Transporter Activity Purine Nucleoside Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Histone Acetyltransferase Activity Response To Progesterone Reproductive Behavior Sulfur Amino Acid Metabolic Process Establishment Of Skin Barrier Biological Process Involved In Interaction With Symbiont Cellular Response To Nutrient Nuclear Estrogen Receptor Binding Lactation Skin Epidermis Development Aspartate Family Amino Acid Metabolic Process Nuclear Receptor Binding Nucleoside Metabolic Process
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