GNMT and ZNF337

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GNMT	ZNF337
Description		glycine N-methyltransferase	zinc finger protein 337
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus
	Molecular Function	Protein Binding Folic Acid Binding Methyltransferase Activity Glycine Binding Transferase Activity Glycine N-methyltransferase Activity Identical Protein Binding S-adenosyl-L-methionine Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Glycogen Metabolic Process Regulation Of Gluconeogenesis Methionine Metabolic Process One-carbon Metabolic Process Methylation S-adenosylhomocysteine Metabolic Process S-adenosylmethionine Metabolic Process Protein Homotetramerization Sarcosine Metabolic Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II
Pathways		Metabolism of ingested SeMet, Sec, MeSec into H2Se Glyoxylate metabolism and glycine degradation Developmental Lineage of Pancreatic Acinar Cells	Generic Transcription Pathway
Drugs		Ademetionine Glycine S-adenosyl-L-homocysteine
Diseases		Hypermethioninemia; Methionine adenosyltransferase deficiency; S-adenosylhomocysteine hydrolase deficiency
GWAS		Apolipoprotein B levels ( 32203549) Blood protein levels ( 30072576) LDL cholesterol levels ( 32203549) Plasma homocysteine levels (post-methionine load test) ( 24651765)	Lung function (FEV1) ( 30061609)
Interacting Genes		31 interacting genes: ADAMTSL4 ARR3 ARRB1 COX7B CTNS DRC12 FRG1 GABRQ GAGE2A HDAC7 HPRT1 KRTAP10-3 KRTAP4-2 NIF3L1 NOTCH2NLA NTAQ1 NUDT18 OTOS PLEKHF2 POT1 PRKACA RPSA SDCBP SNRNP200 SRD5A2 TERF1 TERF2 TERF2IP TINF2 TRIM35 ZNF337	12 interacting genes: ATP5F1C CALCOCO2 CCDC125 CCDC85B COMMD3 GNMT HMBOX1 KRT40 KRTAP10-7 MTUS2 PTGER4 RPGRIP1
Entrez ID		27232	26152
HPRD ID		05970	15779
Ensembl ID		ENSG00000124713	ENSG00000130684
Uniprot IDs		A0A0S2Z5F2 Q14749 V9HW60	A8K5C0 Q6ZUQ0 Q9Y3M9
PDB IDs		1R74 2AZT
Enriched GO Terms of Interacting Partners?		Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Telomeric DNA Binding G-rich Strand Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Chromosome Organization Telomeric D-loop Disassembly Telomeric Loop Disassembly Protein Localization To Chromosome, Telomeric Region Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of DNA Recombination At Telomere Telomere Organization Negative Regulation Of DNA Metabolic Process Telomere Maintenance Via Telomerase Chromosome, Telomeric Region Regulation Of DNA Biosynthetic Process Telomere Assembly DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Telomerase Activity Protection From Non-homologous End Joining At Telomere Regulation Of Chromosome Organization Double-stranded Telomeric DNA Binding Positive Regulation Of DNA Metabolic Process G Protein-coupled Receptor Internalization Telomere Maintenance In Response To DNA Damage Positive Regulation Of Organelle Organization Grooming Behavior Chromosome Organization Nuclear Body Positive Regulation Of Cellular Component Organization Negative Regulation Of Interleukin-2 Production Protein Localization To Chromosome Striated Muscle Dense Body Guanine Phosphoribosyltransferase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Component Organization Interleukin-5 Receptor Complex
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