GNMT and CTNS

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GNMT	CTNS
Description		glycine N-methyltransferase	cystinosin, lysosomal cystine transporter
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GO Annotations	Cellular Component	Cytoplasm Cytosol	Lysosome Lysosomal Membrane Early Endosome Late Endosome Plasma Membrane Membrane Melanosome Membrane Melanosome Extracellular Exosome
	Molecular Function	Protein Binding Folic Acid Binding Methyltransferase Activity Glycine Binding Transferase Activity Glycine N-methyltransferase Activity Identical Protein Binding S-adenosyl-L-methionine Binding	Protein Binding L-cystine Transmembrane Transporter Activity Symporter Activity Solute:proton Symporter Activity
	Biological Process	Glycogen Metabolic Process Regulation Of Gluconeogenesis Methionine Metabolic Process One-carbon Metabolic Process Methylation S-adenosylhomocysteine Metabolic Process S-adenosylmethionine Metabolic Process Protein Homotetramerization Sarcosine Metabolic Process	Lens Development In Camera-type Eye Amino Acid Metabolic Process Glutathione Metabolic Process Monoatomic Ion Transport Brain Development Long-term Memory Grooming Behavior Adult Walking Behavior Visual Learning Protein Transport L-cystine Transport Melanin Biosynthetic Process ATP Metabolic Process Regulation Of Melanin Biosynthetic Process Animal Organ Development System Development Cognition Transmembrane Transport Proton Transmembrane Transport Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling
Pathways		Metabolism of ingested SeMet, Sec, MeSec into H2Se Glyoxylate metabolism and glycine degradation Developmental Lineage of Pancreatic Acinar Cells	Miscellaneous transport and binding events SLC-mediated transport of oligopeptides
Drugs		Ademetionine Glycine S-adenosyl-L-homocysteine	Cystine
Diseases		Hypermethioninemia; Methionine adenosyltransferase deficiency; S-adenosylhomocysteine hydrolase deficiency	Cystinosis
GWAS		Apolipoprotein B levels ( 32203549) Blood protein levels ( 30072576) LDL cholesterol levels ( 32203549) Plasma homocysteine levels (post-methionine load test) ( 24651765)	Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)
Interacting Genes		31 interacting genes: ADAMTSL4 ARR3 ARRB1 COX7B CTNS DRC12 FRG1 GABRQ GAGE2A HDAC7 HPRT1 KRTAP10-3 KRTAP4-2 NIF3L1 NOTCH2NLA NTAQ1 NUDT18 OTOS PLEKHF2 POT1 PRKACA RPSA SDCBP SNRNP200 SRD5A2 TERF1 TERF2 TERF2IP TINF2 TRIM35 ZNF337	1 interacting genes: GNMT
Entrez ID		27232	1497
HPRD ID		05970	05885
Ensembl ID		ENSG00000124713	ENSG00000040531
Uniprot IDs		A0A0S2Z5F2 Q14749 V9HW60	A0A0S2Z3I9 A0A0S2Z3K3 A0A669KB82 I3L4A9 O60931
PDB IDs		1R74 2AZT	8DKE 8DKI 8DKM 8DKW 8DKX 8DYP
Enriched GO Terms of Interacting Partners?		Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Telomeric DNA Binding G-rich Strand Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Chromosome Organization Telomeric D-loop Disassembly Telomeric Loop Disassembly Protein Localization To Chromosome, Telomeric Region Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of DNA Recombination At Telomere Telomere Organization Negative Regulation Of DNA Metabolic Process Telomere Maintenance Via Telomerase Chromosome, Telomeric Region Regulation Of DNA Biosynthetic Process Telomere Assembly DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Telomerase Activity Protection From Non-homologous End Joining At Telomere Regulation Of Chromosome Organization Double-stranded Telomeric DNA Binding Positive Regulation Of DNA Metabolic Process G Protein-coupled Receptor Internalization Telomere Maintenance In Response To DNA Damage Positive Regulation Of Organelle Organization Grooming Behavior Chromosome Organization Nuclear Body Positive Regulation Of Cellular Component Organization Negative Regulation Of Interleukin-2 Production Protein Localization To Chromosome Striated Muscle Dense Body Guanine Phosphoribosyltransferase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Component Organization Interleukin-5 Receptor Complex	Sarcosine Metabolic Process Glycine N-methyltransferase Activity S-adenosylhomocysteine Metabolic Process Glycine Binding Folic Acid Binding S-adenosylmethionine Metabolic Process One-carbon Metabolic Process S-adenosyl-L-methionine Binding Methionine Metabolic Process Purine Nucleoside Metabolic Process Sulfur Amino Acid Metabolic Process Aspartate Family Amino Acid Metabolic Process Nucleoside Metabolic Process Glycogen Metabolic Process Regulation Of Gluconeogenesis Protein Homotetramerization Energy Reserve Metabolic Process Polysaccharide Metabolic Process Regulation Of Glucose Metabolic Process Protein Tetramerization Modified Amino Acid Metabolic Process L-amino Acid Metabolic Process Methyltransferase Activity Protein Homooligomerization Alpha-amino Acid Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Methylation Sulfur Compound Metabolic Process Protein Complex Oligomerization Amino Acid Metabolic Process Generation Of Precursor Metabolites And Energy Regulation Of Small Molecule Metabolic Process Carbohydrate Metabolic Process Purine-containing Compound Metabolic Process
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