CHMP6 and VPS25

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)
HPRD (in vivo, two hybrid, in vitro)

		CHMP6	VPS25
Description		charged multivesicular body protein 6	vacuolar protein sorting 25 homolog
Image
GO Annotations	Cellular Component	Autophagosome Membrane Kinetochore ESCRT III Complex Nuclear Pore Lysosomal Membrane Endosome Multivesicular Body Kinetochore Microtubule Cytosol Plasma Membrane Endosome Membrane Endomembrane System Membrane Midbody Late Endosome Membrane Multivesicular Body Membrane Extracellular Exosome Amphisome Membrane	ESCRT II Complex Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Endosome Membrane Membrane Extracellular Exosome
	Molecular Function	Protein Binding Protein-containing Complex Binding	Structural Molecule Activity Protein Binding Protein Homodimerization Activity
	Biological Process	Plasma Membrane Repair Vesicle Budding From Membrane Autophagy Nucleus Organization Vacuolar Transport Mitotic Metaphase Chromosome Alignment Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Transport Macroautophagy Nuclear Membrane Reassembly Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Regulation Of Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Viral Budding From Plasma Membrane Vesicle Fusion With Vacuole Multivesicular Body-lysosome Fusion Midbody Abscission Multivesicular Body Sorting Pathway Membrane Fission Autophagosome Maturation Regulation Of Mitotic Spindle Assembly Late Endosome To Lysosome Transport Regulation Of Exosomal Secretion ESCRT III Complex Assembly	Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Transport Macroautophagy Multivesicular Body Assembly Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Multivesicular Body Sorting Pathway Membrane Fission
Pathways		Budding and maturation of HIV virion Macroautophagy Pyroptosis Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy Sealing of the nuclear envelope (NE) by ESCRT-III Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex	Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events
Drugs
Diseases
GWAS
Interacting Genes		8 interacting genes: CHMP4A CHMP4B ELOF1 METTL9 SNCA SNF8 VPS25 VPS36	24 interacting genes: APIP ASPG B9D2 BEND5 BPIFA1 CHMP6 CRLF3 EIF4G3 GPR35 LTB4R2 PICK1 REL RHOXF2 SDCBP2 SEPTIN14 SNCA SNF8 SPG21 SPRY2 SYCE1 TADA2A TRIM27 UBC VPS36
Entrez ID		79643	84313
HPRD ID		08564	14396
Ensembl ID		ENSG00000176108	ENSG00000131475
Uniprot IDs		Q96FZ7	Q9BRG1
PDB IDs		2K3W 3HTU	2ZME 3CUQ 3HTU
Enriched GO Terms of Interacting Partners?		Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Organization Multivesicular Body Assembly Late Endosome To Vacuole Transport Endosome Transport Via Multivesicular Body Sorting Pathway Membrane Fission Multivesicular Body Sorting Pathway ESCRT II Complex Endosome Organization Membrane Organization Macroautophagy Vacuolar Transport Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Endosomal Transport Protein Localization To Vacuole Autophagy Vesicle Organization Establishment Of Protein Localization To Organelle Late Endosome Membrane Establishment Of Protein Localization To Vacuole Vesicle-mediated Transport Protein Homodimerization Activity Organelle Assembly ESCRT III Complex Amphisome Membrane Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Vesicle Fusion With Vacuole Nucleus Organization Multivesicular Body-lysosome Fusion Lipid Binding Endosome Viral Budding From Plasma Membrane Lysosomal Membrane Organization Cellular Component Assembly Establishment Of Localization In Cell Organelle Organization Late Endosome To Lysosome Transport Kinetochore Microtubule Viral Budding Via Host ESCRT Complex Regulation Of Mitotic Spindle Assembly Midbody Abscission Regulation Of Microtubule Cytoskeleton Organization Viral Budding Nuclear Membrane Reassembly Intracellular Protein Localization Mitotic Cytokinetic Process Protein Transport Plasma Membrane Repair Multivesicular Body Membrane Protein Targeting To ER	Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Organization ESCRT II Complex Multivesicular Body Assembly Late Endosome To Vacuole Transport Endosome Transport Via Multivesicular Body Sorting Pathway Membrane Fission Multivesicular Body Sorting Pathway Lipid Binding Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Endosome Organization Regulation Of Exosomal Secretion Negative Regulation Of Autophagy Endosomal Transport
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