CHMP6 and CHMP4B

Number of citations of the paper that reports this interaction (PMID 16730941)
46

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		CHMP6	CHMP4B
Gene Name		charged multivesicular body protein 6	charged multivesicular body protein 4B
Image
Gene Ontology Annotations	Cellular Component	Cytosol Membrane Late Endosome Membrane Extracellular Vesicular Exosome	ESCRT III Complex Nucleus Cytoplasm Endosome Cytosol Cytoplasmic Side Of Plasma Membrane Midbody Late Endosome Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Protein N-terminus Binding	Protein Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Cell Separation After Cytokinesis Nucleus Organization Vacuolar Transport Mitotic Metaphase Plate Congression Protein Transport Viral Process Endosomal Transport Viral Life Cycle Membrane Organization Regulation Of Exosomal Secretion	Cell Separation After Cytokinesis Posttranslational Protein Targeting To Membrane Nucleus Organization Vacuolar Transport Mitotic Metaphase Plate Congression Regulation Of Centrosome Duplication Viral Process Endosomal Transport Viral Life Cycle Maintenance Of Lens Transparency Viral Budding Via Host ESCRT Complex Viral Budding Regulation Of Viral Process Protein Homooligomerization Negative Regulation Of Cell Death Membrane Organization Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Neuron Death Regulation Of Mitotic Spindle Assembly Positive Regulation Of Viral Release From Host Cell Negative Regulation Of Autophagic Vacuole Assembly
Pathways		HIV Life Cycle Budding and maturation of HIV virion HIV Infection Endosomal Sorting Complex Required For Transport (ESCRT) Late Phase of HIV Life Cycle	HIV Life Cycle Budding and maturation of HIV virion HIV Infection Endosomal Sorting Complex Required For Transport (ESCRT) Late Phase of HIV Life Cycle
Drugs
Diseases
GWAS			Stearic acid (18:0) plasma levels ( 23362303)
Protein-Protein Interactions		7 interactors: CHMP4A CHMP4B ELOF1 METTL9 SNF8 VPS25 VPS36	14 interactors: CHMP1B CHMP3 CHMP4A CHMP4C CHMP5 CHMP6 EXOSC9 HIPK2 PDCD6IP PIAS2 PTPN23 STAMBP UBE2I VPS4A
Entrez ID		79643	128866
HPRD ID		08564	16642
Ensembl ID		ENSG00000176108	ENSG00000101421
Uniprot IDs		Q96FZ7	Q9H444
PDB IDs		2K3W 3HTU	3C3Q 3UM3 4ABM
Enriched GO Terms of Interacting Partners?		Endosomal Transport Vacuolar Transport Negative Regulation Of Autophagic Vacuole Assembly Protein Targeting To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Membrane Organization Endosome Transport Via Multivesicular Body Sorting Pathway Establishment Of Protein Localization To Organelle Late Endosome To Vacuole Transport Viral Budding Via Host ESCRT Complex Posttranslational Protein Targeting To Membrane Protein Targeting Viral Budding Protein Localization To Organelle Negative Regulation Of Macroautophagy Protein Transport Establishment Of Protein Localization Regulation Of Autophagic Vacuole Assembly Intracellular Transport Cell Separation After Cytokinesis Regulation Of Vacuole Organization Cytoplasmic Transport Protein Targeting To Vacuole Virion Assembly Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Establishment Of Protein Localization To Vacuole Mitotic Metaphase Plate Congression Protein Localization Establishment Of Localization In Cell Metaphase Plate Congression Negative Regulation Of Autophagy Intracellular Protein Transport Establishment Of Chromosome Localization Cellular Localization Cellular Protein Localization Mitotic Sister Chromatid Segregation Membrane Budding Sister Chromatid Segregation Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Regulation Of Autophagy Protein Catabolic Process Nucleus Organization Protein Localization To Endoplasmic Reticulum Protein Targeting To Membrane Maintenance Of Lens Transparency Cellular Macromolecule Catabolic Process Viral Life Cycle Regulation Of Metabolic Process	Cell Separation After Cytokinesis Cell Division Mitotic Metaphase Plate Congression Metaphase Plate Congression Establishment Of Chromosome Localization Nucleus Organization Vacuolar Transport Mitotic Sister Chromatid Segregation Viral Process Sister Chromatid Segregation Viral Life Cycle Chromosome Segregation Regulation Of Centrosome Duplication Regulation Of Centrosome Cycle Mitotic Nuclear Division Mitotic Cell Cycle Process Endosomal Transport Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Mitotic Cell Cycle Viral Budding Via Host ESCRT Complex Regulation Of Mitotic Spindle Assembly Protein Transport Viral Budding Regulation Of Microtubule Cytoskeleton Organization Establishment Of Organelle Localization Regulation Of Spindle Assembly Establishment Of Protein Localization Cell Cycle Process Regulation Of Microtubule-based Process Regulation Of Mitotic Spindle Organization Organelle Localization Regulation Of Cell Cycle Process Protein Localization Membrane Organization Cell Cycle Virion Assembly Regulation Of Cell Cycle Regulation Of Cellular Component Organization Abscission Cellular Macromolecule Catabolic Process Regulation Of Cytoskeleton Organization Regulation Of Organelle Organization Positive Regulation Of Viral Release From Host Cell Intracellular Transport Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Cell Division Cellular Protein Catabolic Process Negative Regulation Of Cytokinesis Membrane Budding Organelle Organization
Tagcloud ?		acting app bidirectional cleaving endocytosed endosomal endosomes hallmarks interruption multivesicular pool postendocytic processed recycled recycling relying rerouted retained retrieval retromer rnai secretase sequentially tgn trafficking tsg101 uncertain vps35 vps4	aculeiform adcc arg58his beaded bfsp1 bfsp2 cataract cerulean connexins coralliform cryaa cryba2 cryba4 crybb1 crybb3 cryga crygb crygc crygd crygs crystallins fasciculiform flaky gja3 gja8 lim2 macedonia pro23thr tmem114
Tagcloud (Difference) ?		acting app bidirectional cleaving endocytosed endosomal endosomes hallmarks interruption multivesicular pool postendocytic processed recycled recycling relying rerouted retained retrieval retromer rnai secretase sequentially tgn trafficking tsg101 uncertain vps35 vps4	aculeiform adcc arg58his beaded bfsp1 bfsp2 cataract cerulean connexins coralliform cryaa cryba2 cryba4 crybb1 crybb3 cryga crygb crygc crygd crygs crystallins fasciculiform flaky gja3 gja8 lim2 macedonia pro23thr tmem114
Tagcloud (Intersection) ?