VPS25 and SEPTIN14

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		VPS25	SEPTIN14
Name		vacuolar protein sorting 25 homolog	septin 14
Structure
GO Annotations	Cellular Component	ESCRT II Complex Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Endosome Membrane Membrane Extracellular Exosome	Acrosomal Vesicle Cytoplasm Cytoskeleton Septin Ring Microtubule Cytoskeleton Axon Dendrite Septin Complex Cytoplasmic Vesicle Cell Division Site Cell Projection Perikaryon Perinuclear Region Of Cytoplasm
	Molecular Function	Structural Molecule Activity Protein Binding Protein Homodimerization Activity	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Molecular Adaptor Activity
	Biological Process	Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Transport Macroautophagy Multivesicular Body Assembly Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Multivesicular Body Sorting Pathway Membrane Fission	Neuron Migration Spermatid Development Intracellular Protein Localization Cell Division Cytoskeleton-dependent Cytokinesis Protein Localization To Perinuclear Region Of Cytoplasm
Pathways		Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events	None
GWAS		No GWAS studies recorded	No GWAS studies recorded
Interacting Genes		24 interacting genes: APIP ASPG B9D2 BEND5 BPIFA1 CHMP6 CRLF3 EIF4G3 GPR35 LTB4R2 PICK1 REL RHOXF2 SDCBP2 SEPTIN14 SNCA SNF8 SPG21 SPRY2 SYCE1 TADA2A TRIM27 UBC VPS36	6 interacting genes: ARMC7 CEBPA FAM124B GORASP2 NTAQ1 VPS25
Entrez ID		84313	346288
HPRD ID		14396	16972
Ensembl ID		ENSG00000131475	ENSG00000154997
Uniprot IDs		Q9BRG1	Q6ZU15
PDB IDs		2ZME 3CUQ 3HTU	8SJJ
GO Terms Enriched among Interactors		Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Organization ESCRT II Complex Multivesicular Body Assembly Late Endosome To Vacuole Transport Endosome Transport Via Multivesicular Body Sorting Pathway Membrane Fission Multivesicular Body Sorting Pathway Lipid Binding Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Endosome Organization Regulation Of Exosomal Secretion Negative Regulation Of Autophagy Endosomal Transport	None