VPS25 and SNF8

Number of citations: 106 (PubMedID 35271311)
Data Source: BioGRID (affinity chromatography technology, biochemical), HPRD (two hybrid)

		VPS25	SNF8
Name		vacuolar protein sorting 25 homolog	SNF8 subunit of ESCRT-II
Structure
GO Annotations	Cellular Component	ESCRT II Complex Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Endosome Membrane Membrane Extracellular Exosome	ESCRT II Complex Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Endosome Cytosol Plasma Membrane Endosome Membrane Membrane Late Endosome Membrane Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Exosome
	Molecular Function	Structural Molecule Activity Protein Binding Protein Homodimerization Activity	Protein Binding Lipid Binding Channel Regulator Activity Protein Homodimerization Activity
	Biological Process	Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Transport Macroautophagy Multivesicular Body Assembly Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Multivesicular Body Sorting Pathway Membrane Fission	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Gene Expression Protein Transport Macroautophagy Endocytic Recycling Multivesicular Body Assembly Regulation Of Protein Catabolic Process Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of MAP Kinase Activity Early Endosome To Late Endosome Transport Positive Regulation Of Protein Catabolic Process Regulation Of Protein Complex Stability Multivesicular Body Sorting Pathway Membrane Fission Positive Regulation Of Exosomal Secretion
Pathways		Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events	Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events
GWAS		No GWAS studies recorded	Coronary heart disease ( 21378990 ) Hip circumference adjusted for BMI ( 34021172 ) Type 2 diabetes ( 29358691 )
Interacting Genes		24 interacting genes: APIP ASPG B9D2 BEND5 BPIFA1 CHMP6 CRLF3 EIF4G3 GPR35 LTB4R2 PICK1 REL RHOXF2 SDCBP2 SEPTIN14 SNCA SNF8 SPG21 SPRY2 SYCE1 TADA2A TRIM27 UBC VPS36	25 interacting genes: ADORA1 AKAP9 CHMP6 CLP1 CT55 DVL2 ELL FANCL GLYCTK GOLGA2 KDM1A NIF3L1 PRMT6 RILP SMARCD1 SUOX SUV39H2 TRIM54 TSG101 TXLNA UBC VAC14 VPS25 VPS36 YWHAE
Entrez ID		84313	11267
HPRD ID		14396	16847
Ensembl ID		ENSG00000131475	ENSG00000159210
Uniprot IDs		Q9BRG1	Q96H20
PDB IDs		2ZME 3CUQ 3HTU	2ZME 3CUQ
GO Terms Enriched among Interactors		Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Organization ESCRT II Complex Multivesicular Body Assembly Late Endosome To Vacuole Transport Endosome Transport Via Multivesicular Body Sorting Pathway Membrane Fission Multivesicular Body Sorting Pathway Lipid Binding Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Endosome Organization Regulation Of Exosomal Secretion Negative Regulation Of Autophagy Endosomal Transport	Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Sorting Pathway Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Organization Endosome Organization Multivesicular Body Assembly Late Endosome To Vacuole Transport Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Membrane Fission Negative Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Signaling Receptor Activity Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Late Endosome Membrane Negative Regulation Of Peptidyl-tyrosine Phosphorylation Macroautophagy Vacuolar Transport Regulation Of Protein Tyrosine Kinase Activity ESCRT II Complex Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Signaling Receptor Activity Vesicle-mediated Transport Endosomal Transport Endosome Membrane Autophagy Vesicle Organization Establishment Of Protein Localization To Vacuole Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Protein Kinase Activity Regulation Of ERBB Signaling Pathway Negative Regulation Of Kinase Activity Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Catabolic Process Negative Regulation Of Metabolic Process Protein Localization To Vacuole Regulation Of Exosomal Secretion Establishment Of Protein Localization Viral Budding Via Host ESCRT Complex Organelle Assembly Negative Regulation Of Protein Phosphorylation Histone H3 Methyltransferase Activity Viral Budding Regulation Of Signal Transduction By P53 Class Mediator Endosome Viral Release From Host Cell Negative Regulation Of Phosphorylation Lysosomal Transport Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Microtubule Nucleation Ubiquitin Protein Ligase Binding