VPS25 and SNF8

Number of citations of the paper that reports this interaction (PMID 14505570)
292

Data Source:
BioGRID (two hybrid, two hybrid, affinity chromatography technology)
HPRD (two hybrid)

		VPS25	SNF8
Gene Name		vacuolar protein sorting 25 homolog (S. cerevisiae)	SNF8, ESCRT-II complex subunit
Image
Gene Ontology Annotations	Cellular Component	ESCRT II Complex Nucleus Nucleoplasm Nucleolus Mitochondrion Cytosol Endosome Membrane Extracellular Vesicular Exosome	ESCRT II Complex Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol Late Endosome Membrane Extracellular Vesicular Exosome
	Molecular Function	Structural Molecule Activity Protein Binding Protein Homodimerization Activity	Protein Binding Transcription Factor Binding Protein Homodimerization Activity
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Endosomal Transport Protein Targeting To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Membrane Organization	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Endosomal Transport Protein Targeting To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Membrane Organization Positive Regulation Of Exosomal Secretion
Pathways		Endosomal Sorting Complex Required For Transport (ESCRT)	Endosomal Sorting Complex Required For Transport (ESCRT)
Drugs
Diseases
GWAS			Coronary heart disease ( 21378990)
Protein-Protein Interactions		10 interactors: APIP BEND5 CHMP6 CRLF3 REL RHOXF2 SNF8 SPRY2 TRIM27 VPS36	15 interactors: ADORA1 CHMP6 DVL2 ELL GOLGA2 KDM1A NIF3L1 PRMT6 RILP SUV39H2 TRIM54 TSG101 VAC14 VPS25 VPS36
Entrez ID		84313	11267
HPRD ID		14396	16847
Ensembl ID		ENSG00000131475
Uniprot IDs		Q9BRG1	Q96H20
PDB IDs		2ZME 3CUQ 3HTU	2ZME 3CUQ
Enriched GO Terms of Interacting Partners?		Endosomal Transport Vacuolar Transport Regulation Of Gene Expression Establishment Of Localization In Cell Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Interleukin-2 Secretion L-methionine Biosynthetic Process From S-adenosylmethionine Cellular Localization Protein Targeting To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Cytokine Production Protein Transport Establishment Of Protein Localization Intracellular Transport Mitotic Cell Cycle Process Regulation Of Transcription, DNA-templated S-adenosylmethionine Cycle Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Calcium Ion Import Endosome Transport Via Multivesicular Body Sorting Pathway Mitotic Cell Cycle Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Late Endosome To Vacuole Transport Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Protein Kinase Activity Lung Growth Interferon-gamma Secretion L-methionine Biosynthetic Process From Methylthioadenosine Regulation Of Transcription From RNA Polymerase II Promoter Membrane Organization Negative Regulation Of Kinase Activity Regulation Of Neurotrophin TRK Receptor Signaling Pathway Protein Localization L-methionine Salvage Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Positive Regulation Of Interleukin-12 Biosynthetic Process Bud Elongation Involved In Lung Branching Negative Regulation Of Cell Death Negative Regulation Of Transferase Activity Cell Cycle Process Negative Regulation Of Viral Release From Host Cell Negative Regulation Of Protein Phosphorylation Establishment Of Organelle Localization Methionine Biosynthetic Process Regulation Of Interleukin-12 Biosynthetic Process	Endosomal Transport Vacuolar Transport Viral Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Circadian Rhythm Protein Localization Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Membrane Organization Protein Transport Regulation Of Gene Expression Regulation Of Metabolic Process Establishment Of Protein Localization Intracellular Transport Transcription, DNA-templated Positive Regulation Of Protein Tyrosine Kinase Activity RNA Biosynthetic Process Cellular Localization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Gene Expression Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Protein Binding Negative Regulation Of Long Term Synaptic Depression Negative Regulation Of Neurotrophin Production Positive Regulation Of Nucleoside Transport Regulation Of Primitive Erythrocyte Differentiation Negative Regulation Of Cardiac Muscle Cell Myoblast Differentiation Regulation Of Protein Tyrosine Kinase Activity Biosynthetic Process Establishment Of Localization In Cell Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Histone H3-R2 Methylation Negative Regulation Of Mucus Secretion 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Negative Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Regulation Of Circadian Rhythm Histone Modification Negative Regulation Of Binding RNA Metabolic Process Convergent Extension Involved In Neural Plate Elongation Regulation Of Long Term Synaptic Depression Protein Targeting To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Tagcloud ?		bmp consequent contexts directs endosomal endosome enu escrt fgf fgfr gestation hyperactivation hypomorphic limbs machineries mutagenesis mysterious patterning polydactylous polydactyly preferential shh sort sorting specification survive unperturbed vacuolar vertebrate	cerevisiae cloning complementation dalton derepression diploids distinguished extremely homozygous impair invertase limitation notably predicts raffinose saccharomyces sick snf1 snf2 snf4 snf5 snf6 snf7 sporulation spt6 ssn20 ssn6 suc2 suppressors
Tagcloud (Difference) ?		bmp consequent contexts directs endosomal endosome enu escrt fgf fgfr gestation hyperactivation hypomorphic limbs machineries mutagenesis mysterious patterning polydactylous polydactyly preferential shh sort sorting specification survive unperturbed vacuolar vertebrate	cerevisiae cloning complementation dalton derepression diploids distinguished extremely homozygous impair invertase limitation notably predicts raffinose saccharomyces sick snf1 snf2 snf4 snf5 snf6 snf7 sporulation spt6 ssn20 ssn6 suc2 suppressors
Tagcloud (Intersection) ?