VPS25 and DCAKD

Data Source: HiPPIP (Novel)

		VPS25	DCAKD
Name		vacuolar protein sorting 25 homolog	dephospho-CoA kinase domain containing
Structure			No pdb structure
GO Annotations	Cellular Component	ESCRT II Complex Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Endosome Membrane Membrane Extracellular Exosome	Cytoplasm Mitochondrial Outer Membrane Membrane
	Molecular Function	Structural Molecule Activity Protein Binding Protein Homodimerization Activity	Nucleotide Binding Dephospho-CoA Kinase Activity ATP Binding
	Biological Process	Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Transport Macroautophagy Multivesicular Body Assembly Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Multivesicular Body Sorting Pathway Membrane Fission	Coenzyme A Biosynthetic Process
Pathways		Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events	Coenzyme A biosynthesis
GWAS		No GWAS studies recorded	Asthma ( 31619474 ) Brain morphology (MOSTest) ( 32665545 ) Chronotype ( 30696823 ) Craniofacial microsomia ( 26853712 ) Heel bone mineral density ( 30598549 ) White matter hyperintensities ( 32358547 ) White matter hyperintensity volume ( 33293549 ) White matter hyperintensity volume (adjusted for hypertension) ( 33293549 ) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549 )
Novel Interactors		1 novel interactors: DCAKD	5 novel interactors: ATXN7L3 LRRC37A4P TMEM101 TMUB2 VPS25
Interacting Genes		24 interacting genes: APIP ASPG B9D2 BEND5 BPIFA1 CHMP6 CRLF3 EIF4G3 GPR35 LTB4R2 PICK1 REL RHOXF2 SDCBP2 SEPTIN14 SNCA SNF8 SPG21 SPRY2 SYCE1 TADA2A TRIM27 UBC VPS36	None recorded
Entrez ID		84313	79877
HPRD ID		14396	08012
Ensembl ID		ENSG00000131475	ENSG00000172992
Uniprot IDs		Q9BRG1	Q8WVC6
PDB IDs		2ZME 3CUQ 3HTU	Not available
GO Terms Enriched among Interactors		Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Organization ESCRT II Complex Multivesicular Body Assembly Late Endosome To Vacuole Transport Endosome Transport Via Multivesicular Body Sorting Pathway Membrane Fission Multivesicular Body Sorting Pathway Lipid Binding Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Endosome Organization Regulation Of Exosomal Secretion Negative Regulation Of Autophagy Endosomal Transport	None