VPS25

Gene Name		vacuolar protein sorting 25 homolog (S. cerevisiae)
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Gene Ontology Annotations	Cellular Component	ESCRT II Complex Nucleus Nucleoplasm Nucleolus Mitochondrion Cytosol Endosome Membrane Extracellular Vesicular Exosome
	Molecular Function	Structural Molecule Activity Protein Binding Protein Homodimerization Activity
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Endosomal Transport Protein Targeting To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Membrane Organization
Pathways		Endosomal Sorting Complex Required For Transport (ESCRT)
Drugs
Diseases
GWAS
Protein-protein Interactions		10 interactors: APIP BEND5 CHMP6 CRLF3 REL RHOXF2 SNF8 SPRY2 TRIM27 VPS36
Entrez ID		84313
HPRD ID		14396
Ensembl ID		ENSG00000131475
Uniprot IDs		Q9BRG1
PDB IDs		2ZME 3CUQ 3HTU
Enriched GO Terms of Interacting Partners?		Endosomal Transport Vacuolar Transport Regulation Of Gene Expression Establishment Of Localization In Cell Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Interleukin-2 Secretion L-methionine Biosynthetic Process From S-adenosylmethionine Cellular Localization Protein Targeting To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Cytokine Production Protein Transport Establishment Of Protein Localization Intracellular Transport Mitotic Cell Cycle Process Regulation Of Transcription, DNA-templated S-adenosylmethionine Cycle Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Calcium Ion Import Endosome Transport Via Multivesicular Body Sorting Pathway Mitotic Cell Cycle Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Late Endosome To Vacuole Transport Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Protein Kinase Activity Lung Growth Interferon-gamma Secretion L-methionine Biosynthetic Process From Methylthioadenosine Regulation Of Transcription From RNA Polymerase II Promoter Membrane Organization Negative Regulation Of Kinase Activity Regulation Of Neurotrophin TRK Receptor Signaling Pathway Protein Localization L-methionine Salvage Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Positive Regulation Of Interleukin-12 Biosynthetic Process Bud Elongation Involved In Lung Branching Negative Regulation Of Cell Death Negative Regulation Of Transferase Activity Cell Cycle Process Negative Regulation Of Viral Release From Host Cell Negative Regulation Of Protein Phosphorylation Establishment Of Organelle Localization Methionine Biosynthetic Process Regulation Of Interleukin-12 Biosynthetic Process
Tagcloud ?		bmp consequent contexts directs endosomal endosome enu escrt fgf fgfr gestation hyperactivation hypomorphic limbs machineries mutagenesis mysterious patterning polydactylous polydactyly preferential shh sort sorting specification survive unperturbed vacuolar vertebrate