VPS25 and SYCE1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		VPS25	SYCE1
Name		vacuolar protein sorting 25 homolog	synaptonemal complex central element protein 1
Structure			No pdb structure
GO Annotations	Cellular Component	ESCRT II Complex Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Endosome Membrane Membrane Extracellular Exosome	Synaptonemal Complex Central Element Nucleus Chromosome
	Molecular Function	Structural Molecule Activity Protein Binding Protein Homodimerization Activity	Protein Binding
	Biological Process	Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Transport Macroautophagy Multivesicular Body Assembly Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Multivesicular Body Sorting Pathway Membrane Fission	Synaptonemal Complex Assembly Cell Division Meiotic Cell Cycle Synaptonemal Complex Organization
Pathways		Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events	Meiotic synapsis
GWAS		No GWAS studies recorded	No GWAS studies recorded
Novel Interactors		1 novel interactors: DCAKD	None recorded
Interacting Genes		24 interacting genes: APIP ASPG B9D2 BEND5 BPIFA1 CHMP6 CRLF3 EIF4G3 GPR35 LTB4R2 PICK1 REL RHOXF2 SDCBP2 SEPTIN14 SNCA SNF8 SPG21 SPRY2 SYCE1 TADA2A TRIM27 UBC VPS36	45 interacting genes: ALOX5 ARNT2 BEX2 BFSP2 CBY2 CCDC102B CCHCR1 CFAP100 CINP CNN1 EDRF1 EXOC8 FAM161A FAM161B HAUS1 HMG20B HSPB1 HSPB7 IQUB KAT5 KIFC3 KRT18 MBD3 MPV17 MRFAP1L1 NME7 PSTPIP1 RALBP1 RBCK1 RUNX1T1 SCNM1 SKA1 SMARCE1 SPATC1L SSX2 STX19 TFIP11 TPM3 TRAF1 TRIM41 TSG101 TXN2 VPS25 WASHC3 ZNF124
Entrez ID		84313	93426
HPRD ID		14396	12598
Ensembl ID		ENSG00000131475	ENSG00000171772
Uniprot IDs		Q9BRG1	A0A0B4J1R9 Q8N0S2
PDB IDs		2ZME 3CUQ 3HTU	Not available
GO Terms Enriched among Interactors		Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Organization ESCRT II Complex Multivesicular Body Assembly Late Endosome To Vacuole Transport Endosome Transport Via Multivesicular Body Sorting Pathway Membrane Fission Multivesicular Body Sorting Pathway Lipid Binding Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Endosome Organization Regulation Of Exosomal Secretion Negative Regulation Of Autophagy Endosomal Transport	Cytoskeleton