VPS25 and ASPG

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		VPS25	ASPG
Name		vacuolar protein sorting 25 homolog	asparaginase
Structure			No pdb structure
GO Annotations	Cellular Component	ESCRT II Complex Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Endosome Membrane Membrane Extracellular Exosome	Cytosol
	Molecular Function	Structural Molecule Activity Protein Binding Protein Homodimerization Activity	1-alkyl-2-acetylglycerophosphocholine Esterase Activity Asparaginase Activity Phosphatidylcholine Lysophospholipase Activity Protein Binding Transferase Activity Acyltransferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Hydrolase Activity
	Biological Process	Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Transport Macroautophagy Multivesicular Body Assembly Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Multivesicular Body Sorting Pathway Membrane Fission	Amino Acid Metabolic Process Lipid Metabolic Process Aspartate Family Amino Acid Metabolic Process Lipid Catabolic Process
Pathways		Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events	Aspartate and asparagine metabolism
Drugs		None	Procaine
GWAS		No GWAS studies recorded	Body mass index ( 26426971 ) Plasma free amino acid levels (adjusted for one other PFAA) ( 30659259 ) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259 ) Plasma free asparagine levels ( 30659259 ) Refractive error ( 32231278 ) Schizophrenia ( 29483656 ) Serum metabolite concentrations in chronic kidney disease ( 29545352 ) Serum metabolite levels ( 33031748 )
Interacting Genes		24 interacting genes: APIP ASPG B9D2 BEND5 BPIFA1 CHMP6 CRLF3 EIF4G3 GPR35 LTB4R2 PICK1 REL RHOXF2 SDCBP2 SEPTIN14 SNCA SNF8 SPG21 SPRY2 SYCE1 TADA2A TRIM27 UBC VPS36	12 interacting genes: CEACAM6 CIMIP1 DMRT3 GSDMD MYOZ3 RTP5 SGK1 SHC3 TEKT3 TMEM115 USP2 VPS25
Entrez ID		84313	374569
HPRD ID		14396	19180
Ensembl ID		ENSG00000131475	ENSG00000166183
Uniprot IDs		Q9BRG1	G3V1Y8 Q86U10
PDB IDs		2ZME 3CUQ 3HTU	Not available
GO Terms Enriched among Interactors		Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Organization ESCRT II Complex Multivesicular Body Assembly Late Endosome To Vacuole Transport Endosome Transport Via Multivesicular Body Sorting Pathway Membrane Fission Multivesicular Body Sorting Pathway Lipid Binding Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Endosome Organization Regulation Of Exosomal Secretion Negative Regulation Of Autophagy Endosomal Transport	None