VPS25 and B9D2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		VPS25	B9D2
Name		vacuolar protein sorting 25 homolog	B9 domain containing 2
Structure			No pdb structure
GO Annotations	Cellular Component	ESCRT II Complex Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Endosome Membrane Membrane Extracellular Exosome	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Cilium Membrane MKS Complex Ciliary Basal Body Cell Projection
	Molecular Function	Structural Molecule Activity Protein Binding Protein Homodimerization Activity	Protein Binding Gamma-tubulin Binding
	Biological Process	Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Transport Macroautophagy Multivesicular Body Assembly Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Multivesicular Body Sorting Pathway Membrane Fission	Cell Projection Organization Cilium Assembly
Pathways		Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
GWAS		No GWAS studies recorded	Colorectal cancer ( 24836286 ) Colorectal cancer or advanced adenoma ( 30510241 ) Coronary artery disease ( 29212778 32469254 ) Preterm birth (maternal effect) ( 28877031 ) Pulse pressure ( 27841878 )
Interacting Genes		24 interacting genes: APIP ASPG B9D2 BEND5 BPIFA1 CHMP6 CRLF3 EIF4G3 GPR35 LTB4R2 PICK1 REL RHOXF2 SDCBP2 SEPTIN14 SNCA SNF8 SPG21 SPRY2 SYCE1 TADA2A TRIM27 UBC VPS36	8 interacting genes: ALKBH7 P4HA3 PLEKHA7 QARS1 SAXO4 SPAG8 TLX3 VPS25
Entrez ID		84313	80776
HPRD ID		14396	14613
Ensembl ID		ENSG00000131475	ENSG00000123810
Uniprot IDs		Q9BRG1	Q9BPU9
PDB IDs		2ZME 3CUQ 3HTU	Not available
GO Terms Enriched among Interactors		Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Organization ESCRT II Complex Multivesicular Body Assembly Late Endosome To Vacuole Transport Endosome Transport Via Multivesicular Body Sorting Pathway Membrane Fission Multivesicular Body Sorting Pathway Lipid Binding Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Endosome Organization Regulation Of Exosomal Secretion Negative Regulation Of Autophagy Endosomal Transport	None