VPS25 and EIF4G3

Number of citations of the paper that reports this interaction (PubMedID 35780119)
58

Data Source:
BioGRID (unspecified method)

		VPS25	EIF4G3
Description		vacuolar protein sorting 25 homolog	eukaryotic translation initiation factor 4 gamma 3
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GO Annotations	Cellular Component	ESCRT II Complex Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Endosome Membrane Membrane Extracellular Exosome	Cytosol Eukaryotic Translation Initiation Factor 4F Complex
	Molecular Function	Structural Molecule Activity Protein Binding Protein Homodimerization Activity	RNA Cap Binding RNA Binding MRNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding
	Biological Process	Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Transport Macroautophagy Multivesicular Body Assembly Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Multivesicular Body Sorting Pathway Membrane Fission	Translation Translational Initiation Regulation Of Translation Regulation Of Translational Initiation Spermatid Development Negative Regulation Of Autophagy Positive Regulation Of Translation
Pathways		Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events	ISG15 antiviral mechanism
Drugs
Diseases
GWAS			Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Chronotype ( 30696823) Cognitive decline rate in late mild cognitive impairment ( 26252872) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) General risk tolerance (MTAG) ( 30643258) Mean spheric corpuscular volume ( 32888494) Morning person ( 30696823) Postoperative acute renal failure after cardiac surgery ( 30678657) Red blood cell count ( 32888494) Social science traits (pleiotropy) (HIPO component 1) ( 30289880) Superior frontal gyrus grey matter volume ( 25335168)
Interacting Genes		24 interacting genes: APIP ASPG B9D2 BEND5 BPIFA1 CHMP6 CRLF3 EIF4G3 GPR35 LTB4R2 PICK1 REL RHOXF2 SDCBP2 SEPTIN14 SNCA SNF8 SPG21 SPRY2 SYCE1 TADA2A TRIM27 UBC VPS36	17 interacting genes: CAMK1 CTNND1 DDX19B EIF4A1 EIF4E HSPB1 LIG4 LSM3 MKNK1 PABPC1 PCNT PSMB6 RNF10 TRIM25 VAV2 VPS25 WDR37
Entrez ID		84313	8672
HPRD ID		14396	06802
Ensembl ID		ENSG00000131475	ENSG00000075151
Uniprot IDs		Q9BRG1	A0A0A0MSA7 A0A804HJV5 A0A8I5QJH9 A0A8J9G7U8 B4DXR2 O43432 Q59GJ0
PDB IDs		2ZME 3CUQ 3HTU	1HU3
Enriched GO Terms of Interacting Partners?		Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Organization ESCRT II Complex Multivesicular Body Assembly Late Endosome To Vacuole Transport Endosome Transport Via Multivesicular Body Sorting Pathway Membrane Fission Multivesicular Body Sorting Pathway Lipid Binding Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Endosome Organization Regulation Of Exosomal Secretion Negative Regulation Of Autophagy Endosomal Transport	Cytoplasmic Stress Granule Nucleus Cytoplasm RNA Cap Binding Eukaryotic Translation Initiation Factor 4F Complex Cytosol Calcium/calmodulin-dependent Protein Kinase Activity Extracellular Exosome RNA Binding Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Translation
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