CHMP6 and VPS36

Number of citations of the paper that reports this interaction (PMID 14505570)
292

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CHMP6	VPS36
Gene Name		charged multivesicular body protein 6	vacuolar protein sorting 36 homolog (S. cerevisiae)
Image
Gene Ontology Annotations	Cellular Component	Cytosol Membrane Late Endosome Membrane Extracellular Vesicular Exosome	Nucleus Lysosome Endosome Late Endosome Cytosol Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Protein N-terminus Binding	Protein Binding Phosphatidylinositol-3-phosphate Binding Ubiquitin Binding
	Biological Process	Cell Separation After Cytokinesis Nucleus Organization Vacuolar Transport Mitotic Metaphase Plate Congression Protein Transport Viral Process Endosomal Transport Viral Life Cycle Membrane Organization Regulation Of Exosomal Secretion	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Transport Endosomal Transport Membrane Organization
Pathways		HIV Life Cycle Budding and maturation of HIV virion HIV Infection Endosomal Sorting Complex Required For Transport (ESCRT) Late Phase of HIV Life Cycle	Endosomal Sorting Complex Required For Transport (ESCRT)
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: CHMP4A CHMP4B ELOF1 METTL9 SNF8 VPS25 VPS36	7 interactors: CHMP6 RILP SNF8 SPRY2 TSG101 UBC VPS25
Entrez ID		79643	51028
HPRD ID		08564	12620
Ensembl ID		ENSG00000176108	ENSG00000136100
Uniprot IDs		Q96FZ7	Q86VN1
PDB IDs		2K3W 3HTU	2HTH 2ZME 3CUQ
Enriched GO Terms of Interacting Partners?		Endosomal Transport Vacuolar Transport Negative Regulation Of Autophagic Vacuole Assembly Protein Targeting To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Membrane Organization Endosome Transport Via Multivesicular Body Sorting Pathway Establishment Of Protein Localization To Organelle Late Endosome To Vacuole Transport Viral Budding Via Host ESCRT Complex Posttranslational Protein Targeting To Membrane Protein Targeting Viral Budding Protein Localization To Organelle Negative Regulation Of Macroautophagy Protein Transport Establishment Of Protein Localization Regulation Of Autophagic Vacuole Assembly Intracellular Transport Cell Separation After Cytokinesis Regulation Of Vacuole Organization Cytoplasmic Transport Protein Targeting To Vacuole Virion Assembly Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Establishment Of Protein Localization To Vacuole Mitotic Metaphase Plate Congression Protein Localization Establishment Of Localization In Cell Metaphase Plate Congression Negative Regulation Of Autophagy Intracellular Protein Transport Establishment Of Chromosome Localization Cellular Localization Cellular Protein Localization Mitotic Sister Chromatid Segregation Membrane Budding Sister Chromatid Segregation Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Regulation Of Autophagy Protein Catabolic Process Nucleus Organization Protein Localization To Endoplasmic Reticulum Protein Targeting To Membrane Maintenance Of Lens Transparency Cellular Macromolecule Catabolic Process Viral Life Cycle Regulation Of Metabolic Process	Endosomal Transport Vacuolar Transport Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Establishment Of Localization In Cell Cellular Localization Protein Targeting To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Intracellular Transport Endosome Transport Via Multivesicular Body Sorting Pathway Membrane Organization Late Endosome To Vacuole Transport Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Viral Protein Processing Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Transport Protein Catabolic Process Viral Life Cycle Establishment Of Protein Localization Protein Targeting To Vacuole Virion Assembly Establishment Of Protein Localization To Vacuole Intracellular Transport Of Virus Cellular Macromolecule Catabolic Process Protein Localization Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Establishment Of Protein Localization To Organelle Cell Cycle Process Positive Regulation Of Exocytosis Protein Targeting Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Negative Regulation Of Cardiac Muscle Cell Myoblast Differentiation Cell Cycle Protein Localization To Organelle Viral Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Transport Proteolysis Positive Regulation Of Protein Ubiquitination Mitotic Cell Cycle Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Cytoplasmic Transport Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cellular Protein Catabolic Process
Tagcloud ?		acting app bidirectional cleaving endocytosed endosomal endosomes hallmarks interruption multivesicular pool postendocytic processed recycled recycling relying rerouted retained retrieval retromer rnai secretase sequentially tgn trafficking tsg101 uncertain vps35 vps4	bicoid budding complementation eap20 eap30 eap45 endosomal escrt escrtii evolutionarily exemplifies fertilised implication inward juxtanuclear localisation opts orthologue outwards rab7 staufen staufen1 tedly topologically trafficking tri unexpec vesicular vps22
Tagcloud (Difference) ?		acting app bidirectional cleaving endocytosed endosomes hallmarks interruption multivesicular pool postendocytic processed recycled recycling relying rerouted retained retrieval retromer rnai secretase sequentially tgn tsg101 uncertain vps35 vps4	bicoid budding complementation eap20 eap30 eap45 escrt escrtii evolutionarily exemplifies fertilised implication inward juxtanuclear localisation opts orthologue outwards rab7 staufen staufen1 tedly topologically tri unexpec vesicular vps22
Tagcloud (Intersection) ?		endosomal trafficking