CHMP6 and VPS36

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid)

		CHMP6	VPS36
Description		charged multivesicular body protein 6	vacuolar protein sorting 36 homolog
Image
GO Annotations	Cellular Component	Autophagosome Membrane Kinetochore ESCRT III Complex Nuclear Pore Lysosomal Membrane Endosome Multivesicular Body Kinetochore Microtubule Cytosol Plasma Membrane Endosome Membrane Endomembrane System Membrane Midbody Late Endosome Membrane Multivesicular Body Membrane Extracellular Exosome Amphisome Membrane	ESCRT II Complex Nucleus Cytoplasm Lysosome Endosome Late Endosome Cytosol Membrane Late Endosome Membrane Extracellular Exosome
	Molecular Function	Protein Binding Protein-containing Complex Binding	Protein Binding Lipid Binding Phosphatidylinositol-3-phosphate Binding Ubiquitin Binding
	Biological Process	Plasma Membrane Repair Vesicle Budding From Membrane Autophagy Nucleus Organization Vacuolar Transport Mitotic Metaphase Chromosome Alignment Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Transport Macroautophagy Nuclear Membrane Reassembly Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Regulation Of Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Viral Budding From Plasma Membrane Vesicle Fusion With Vacuole Multivesicular Body-lysosome Fusion Midbody Abscission Multivesicular Body Sorting Pathway Membrane Fission Autophagosome Maturation Regulation Of Mitotic Spindle Assembly Late Endosome To Lysosome Transport Regulation Of Exosomal Secretion ESCRT III Complex Assembly	Protein Transport Macroautophagy Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Membrane Fission
Pathways		Budding and maturation of HIV virion Macroautophagy Pyroptosis Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy Sealing of the nuclear envelope (NE) by ESCRT-III Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex	Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events
Drugs
Diseases
GWAS			Lewy body disease ( 25188341)
Interacting Genes		8 interacting genes: CHMP4A CHMP4B ELOF1 METTL9 SNCA SNF8 VPS25 VPS36	8 interacting genes: CHMP6 RILP SNCA SNF8 SPRY2 TSG101 UBC VPS25
Entrez ID		79643	51028
HPRD ID		08564	12620
Ensembl ID		ENSG00000176108	ENSG00000136100
Uniprot IDs		Q96FZ7	Q86VN1
PDB IDs		2K3W 3HTU	2HTH 2ZME 3CUQ
Enriched GO Terms of Interacting Partners?		Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Organization Multivesicular Body Assembly Late Endosome To Vacuole Transport Endosome Transport Via Multivesicular Body Sorting Pathway Membrane Fission Multivesicular Body Sorting Pathway ESCRT II Complex Endosome Organization Membrane Organization Macroautophagy Vacuolar Transport Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Endosomal Transport Protein Localization To Vacuole Autophagy Vesicle Organization Establishment Of Protein Localization To Organelle Late Endosome Membrane Establishment Of Protein Localization To Vacuole Vesicle-mediated Transport Protein Homodimerization Activity Organelle Assembly ESCRT III Complex Amphisome Membrane Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Vesicle Fusion With Vacuole Nucleus Organization Multivesicular Body-lysosome Fusion Lipid Binding Endosome Viral Budding From Plasma Membrane Lysosomal Membrane Organization Cellular Component Assembly Establishment Of Localization In Cell Organelle Organization Late Endosome To Lysosome Transport Kinetochore Microtubule Viral Budding Via Host ESCRT Complex Regulation Of Mitotic Spindle Assembly Midbody Abscission Regulation Of Microtubule Cytoskeleton Organization Viral Budding Nuclear Membrane Reassembly Intracellular Protein Localization Mitotic Cytokinetic Process Protein Transport Plasma Membrane Repair Multivesicular Body Membrane Protein Targeting To ER	Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Sorting Pathway Endosome Organization Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Organization Multivesicular Body Assembly Late Endosome To Vacuole Transport Membrane Fission Vacuolar Transport Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Protein Tyrosine Kinase Activity Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Signaling Receptor Activity Regulation Of ERBB Signaling Pathway Regulation Of Phosphorus Metabolic Process Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Protein Metabolic Process Endosomal Transport Regulation Of Exosomal Secretion Endosome Membrane Membrane Organization Negative Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Protein Tyrosine Kinase Activity Vesicle Organization Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Establishment Of Localization In Cell Negative Regulation Of ERBB Signaling Pathway Regulation Of Signaling Receptor Activity Late Endosome Membrane Regulation Of Phosphorylation Macroautophagy ESCRT II Complex Regulation Of Exocytosis Vesicle-mediated Transport Regulation Of Protein Kinase Activity Establishment Of Protein Localization To Vacuole Regulation Of Kinase Activity Regulation Of Protein Modification Process Negative Regulation Of Protein Kinase Activity Negative Regulation Of Kinase Activity Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Exocytosis Autophagy Organelle Assembly Endosome Protein Localization To Vacuole Organelle Organization Negative Regulation Of Protein Phosphorylation
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