VPS25 and CRLF3

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		VPS25	CRLF3
Name		vacuolar protein sorting 25 homolog	cytokine receptor like factor 3
Structure			No pdb structure
GO Annotations	Cellular Component	ESCRT II Complex Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Endosome Membrane Membrane Extracellular Exosome	Nucleus Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Structural Molecule Activity Protein Binding Protein Homodimerization Activity	DNA Binding Protein Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Transport Macroautophagy Multivesicular Body Assembly Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Multivesicular Body Sorting Pathway Membrane Fission	Negative Regulation Of Cell Growth Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events	None
GWAS		No GWAS studies recorded	Birth weight ( 27680694 ) Chronic obstructive pulmonary disease ( 30804561 ) Cutaneous leishmaniasis ( 32830257 ) Height ( 18391951 28552196 ) Hip circumference adjusted for BMI ( 34021172 ) Lymphocyte percentage of white cells ( 32888494 ) Mean corpuscular hemoglobin ( 29403010 ) Platelet distribution width ( 32888494 ) Waist circumference adjusted for body mass index ( 34021172 )
Interacting Genes		24 interacting genes: APIP ASPG B9D2 BEND5 BPIFA1 CHMP6 CRLF3 EIF4G3 GPR35 LTB4R2 PICK1 REL RHOXF2 SDCBP2 SEPTIN14 SNCA SNF8 SPG21 SPRY2 SYCE1 TADA2A TRIM27 UBC VPS36	10 interacting genes: APPL2 DDIT4L KCTD21 KDM1A L3MBTL3 LGALS14 MYOZ3 RBM14 VPS25 ZFP1
Entrez ID		84313	51379
HPRD ID		14396	16757
Ensembl ID		ENSG00000131475	ENSG00000176390
Uniprot IDs		Q9BRG1	Q8IUI8
PDB IDs		2ZME 3CUQ 3HTU	Not available
GO Terms Enriched among Interactors		Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Organization ESCRT II Complex Multivesicular Body Assembly Late Endosome To Vacuole Transport Endosome Transport Via Multivesicular Body Sorting Pathway Membrane Fission Multivesicular Body Sorting Pathway Lipid Binding Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Endosome Organization Regulation Of Exosomal Secretion Negative Regulation Of Autophagy Endosomal Transport	Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Regulation Of Chromatin Organization