FAM118B and NGEF

Number of citations: 0 (PubMedID 21900206)
Data Source: BioGRID (two hybrid)

		FAM118B	NGEF
Name		family with sequence similarity 118 member B	neuronal guanine nucleotide exchange factor
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cajal Body	Cytoplasm Cytosol Membrane Growth Cone Cell Projection Glutamatergic Synapse
	Molecular Function	Protein Binding Identical Protein Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Ephrin Receptor Binding
	Biological Process	None	Nervous System Development Cell Differentiation Regulation Of Actin Cytoskeleton Organization Regulation Of GTPase Activity Ephrin Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Dendritic Spine Morphogenesis Regulation Of Synapse Pruning
Pathways		None	NRAGE signals death through JNK EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse G alpha (12/13) signalling events RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
GWAS		No GWAS studies recorded	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Bipolar disorder ( 31043756 ) Contrast sensitivity ( 24152035 ) Heel bone mineral density ( 28869591 30598549 ) Parkinson's disease ( 32201043 ) Pursuit maintenance gain ( 29064472 ) Schizophrenia ( 23974872 25056061 28991256 29483656 30285260 ) Sudden cardiac arrest ( 30169657 ) Superior temporal sulcus banks volume ( 31530798 )
Interacting Genes		29 interacting genes: BAG5 CEP126 CEP70 CTSB FAM118A FAM20C GNB2 ING5 ITFG1 MCM3AP MED31 NGEF PDCD10 PIAS2 QARS1 RAD54L2 RASGRP2 RBM48 SDCBP SEMA5B SETDB1 SHC1 SPRED1 SUMO1 SUMO1P1 TMSB4X VIM ZNF235 ZNF746	16 interacting genes: ATP5F1C C7orf25 C8orf33 EPHA4 FAM118B HCK LCOR MRPL44 NUDT21 RHOA SH2D1A SMO TAF1D TRIM55 TRIM63 USP7
Entrez ID		79607	25791
HPRD ID		07952	10442
Ensembl ID		ENSG00000197798	ENSG00000066248
Uniprot IDs		J3KP39 Q9BPY3	B4DDI2 Q8N5V2
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Protein Sumoylation PML Body Organization	None