NGEF and FAM118B

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		NGEF	FAM118B
Gene Name		neuronal guanine nucleotide exchange factor	family with sequence similarity 118, member B
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Membrane Growth Cone	Cajal Body
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity
	Biological Process	Small GTPase Mediated Signal Transduction Axon Guidance Positive Regulation Of Rho GTPase Activity Positive Regulation Of Apoptotic Process Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Dendritic Spine Morphogenesis Apoptotic Signaling Pathway
Pathways		Signaling by GPCR Signalling by NGF Axon guidance Cell death signalling via NRAGE, NRIF and NADE p75 NTR receptor-mediated signalling Rho GTPase cycle EPHA-mediated growth cone collapse GPCR downstream signaling NRAGE signals death through JNK Signaling by Rho GTPases EPH-Ephrin signaling G alpha (12/13) signalling events
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: ATP5C1 C7orf25 C8orf33 EPHA4 FAM118B MRPL44 NUDT21 TAF1D	26 interactors: BAG5 CEP70 CTSB FAM118A FAM20C GNB2 ING5 ITFG1 KIAA1377 MCM3AP MED31 NGEF QARS RASGRP2 RBM48 SDCBP SEMA5B SETDB1 SHC1 SPRED1 SUMO1 SUMO1P1 TMSB4X VIM ZNF235 ZNF746
Entrez ID		25791	79607
HPRD ID		10442	07952
Ensembl ID		ENSG00000066248	ENSG00000197798
Uniprot IDs		B4DDI2 Q8N5V2	J3KP39 Q9BPY3
PDB IDs
Enriched GO Terms of Interacting Partners?		DNA-templated Transcription, Termination Positive Regulation Of Rho Guanyl-nucleotide Exchange Factor Activity Fasciculation Of Motor Neuron Axon Fasciculation Of Sensory Neuron Axon Negative Regulation Of Axon Regeneration	Regulation Of Metabolic Process Developmental Process Anatomical Structure Development Regulation Of Signal Transduction Platelet Activation Regulation Of Signaling Glutaminyl-tRNA Aminoacylation Osteoclast Maturation Ras Protein Signal Transduction Organelle Organization Regulation Of Cellular Component Organization Multicellular Organismal Development Peptidyl-lysine Modification Prolyl-tRNA Aminoacylation Regulation Of Cellular Process Small GTPase Mediated Signal Transduction Actin Filament-based Process Negative Regulation Of Dendritic Spine Morphogenesis Cytoskeleton Organization Ephrin Receptor Signaling Pathway Positive Regulation Of Extracellular Vesicular Exosome Assembly Glutamyl-tRNA Aminoacylation PML Body Organization Negative Regulation Of Protein Refolding Odontoblast Differentiation Regulation Of Intracellular Signal Transduction
Tagcloud ?		1h aangef amide asn asp asparaginyl aspartyl backbone capillary carry ce deposited deposits deprotonation inventory isoasp isoaspartate isomerization isopeptide isotope kd2o kh2o limiting notion peptides proton succinimide validate velocity
Tagcloud (Difference) ?		1h aangef amide asn asp asparaginyl aspartyl backbone capillary carry ce deposited deposits deprotonation inventory isoasp isoaspartate isomerization isopeptide isotope kd2o kh2o limiting notion peptides proton succinimide validate velocity
Tagcloud (Intersection) ?