FAM118B and BAG5

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid)

		FAM118B	BAG5
Name		family with sequence similarity 118 member B	BAG cochaperone 5
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Cajal Body	Nucleus Cytoplasm Mitochondrion Cytosol Membrane Inclusion Body Junctional Membrane Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Identical Protein Binding	Adenyl-nucleotide Exchange Factor Activity Protein Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Protein-folding Chaperone Binding Ubiquitin Ligase Inhibitor Activity
	Biological Process	None	Protein Folding Golgi Organization Negative Regulation Of Neuron Projection Development Negative Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Stabilization Negative Regulation Of Protein Refolding Regulation Of Inclusion Body Assembly Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Pathways		None	Regulation of HSF1-mediated heat shock response
GWAS		No GWAS studies recorded	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Body mass index ( 26426971 ) Brain morphology (MOSTest) ( 32665545 ) Broad depression or schizophrenia ( 30626913 ) Depression ( 29700475 ) Schizophrenia ( 25056061 )
Interacting Genes		29 interacting genes: BAG5 CEP126 CEP70 CTSB FAM118A FAM20C GNB2 ING5 ITFG1 MCM3AP MED31 NGEF PDCD10 PIAS2 QARS1 RAD54L2 RASGRP2 RBM48 SDCBP SEMA5B SETDB1 SHC1 SPRED1 SUMO1 SUMO1P1 TMSB4X VIM ZNF235 ZNF746	19 interacting genes: BANP CDCA7L CIRBP CREBBP DES EFEMP1 FAM118B GOLGA6A KASH5 KRTAP5-4 LRRK1 PINK1 PRKN SNCA STUB1 THAP1 TP53 TRIM27 VCP
Entrez ID		79607	9529
HPRD ID		07952	04862
Ensembl ID		ENSG00000197798	ENSG00000166170
Uniprot IDs		J3KP39 Q9BPY3	A0A024R6M6 Q9UL15
PDB IDs		Not available	2D9D 3A8Y
GO Terms Enriched among Interactors		Protein Sumoylation PML Body Organization	Regulation Of Mitophagy Regulation Of Autophagy Of Mitochondrion Positive Regulation Of ATP Biosynthetic Process Identical Protein Binding Dopamine Transport Regulation Of Purine Nucleotide Metabolic Process Mitochondrion To Lysosome Vesicle-mediated Transport Positive Regulation Of Mitophagy Cellular Response To Hydrogen Sulfide Regulation Of ATP Biosynthetic Process Regulation Of Dopamine Secretion Regulation Of Oxidative Phosphorylation Cellular Response To Topologically Incorrect Protein Positive Regulation Of Autophagy Of Mitochondrion Regulation Of Aerobic Respiration Positive Regulation Of Protein-containing Complex Assembly Monoamine Transport Regulation Of Protein Stability Regulation Of Autophagy Response To Hydrogen Sulfide Negative Regulation Of Autophagy Protein Stabilization Negative Regulation Of Mitochondrial Fission Positive Regulation Of ATP Metabolic Process Regulation Of Mitochondrion Organization Regulation Of Synaptic Vesicle Transport Regulation Of Catecholamine Secretion Negative Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Protein-containing Complex Assembly Lewy Body Dopamine Uptake Involved In Synaptic Transmission Mitochondrion Organization Positive Regulation Of Mitochondrial Membrane Potential Aggresome Assembly Regulation Of Cellular Respiration Regulation Of Release Of Cytochrome C From Mitochondria Tau Protein Binding Positive Regulation Of Post-translational Protein Modification Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Reactive Oxygen Species Metabolic Process Hsp70 Protein Binding Autophagy Ubiquitin Protein Ligase Binding Positive Regulation Of Organelle Organization Macroautophagy Inclusion Body Assembly Positive Regulation Of Small Molecule Metabolic Process Mitophagy Fibrillar Center Protein Destabilization