FAM118B and CTSB

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		FAM118B	CTSB
Gene Name		family with sequence similarity 118, member B	cathepsin B
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cajal Body	Extracellular Region Extracellular Space Intracellular Nucleolus Mitochondrion Lysosome Endolysosome Lumen Melanosome Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function		Cysteine-type Endopeptidase Activity Protein Binding Collagen Binding Peptidase Activity Cysteine-type Peptidase Activity Proteoglycan Binding
	Biological Process		Toll-like Receptor Signaling Pathway Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Epithelial Cell Differentiation Regulation Of Apoptotic Process Innate Immune Response Decidualization Regulation Of Catalytic Activity Proteolysis Involved In Cellular Protein Catabolic Process Cellular Response To Thyroid Hormone Stimulus
Pathways			Toll-Like Receptors Cascades Trafficking and processing of endosomal TLR Collagen formation Collagen degradation MHC class II antigen presentation Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Adaptive Immune System Innate Immune System
Drugs			2-Aminoethanimidic Acid 3-Amino-4-Oxybenzyl-2-Butanone 3-Methylphenylalanine N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-Proline 2-Pyridinethiol Diphenylacetic Acid N-[1-Hydroxycarboxyethyl-Carbonyl]Leucylamino-2-Methyl-Butane N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}- N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCINE BENZYL N-({(2S,3S)-3-[(PROPYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINATE METHYL N-({(2S,3S)-3-[(PROPYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINATE N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCYL-L-ALANINE N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCYL-L-ISOLEUCINE N-({(2S,3S)-3-[(BENZYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINE
Diseases
GWAS
Protein-Protein Interactions		26 interactors: BAG5 CEP70 CTSB FAM118A FAM20C GNB2 ING5 ITFG1 KIAA1377 MCM3AP MED31 NGEF QARS RASGRP2 RBM48 SDCBP SEMA5B SETDB1 SHC1 SPRED1 SUMO1 SUMO1P1 TMSB4X VIM ZNF235 ZNF746	33 interactors: A2M ACAN ADAMTSL4 ANXA2 ANXA7 APOE APP BAG6 BGLAP CDKN1A CST3 CST7 CSTA CSTB CTSD FAM118B HNRNPD IGF1 INS MARCKS PARP1 PLAU REN RGS2 S100A10 SERPINB13 SLPI SPHK1 SPINT2 SPRY2 SRPX2 UBQLN4 XRN1
Entrez ID		79607	1508
HPRD ID		07952	00287
Ensembl ID		ENSG00000197798	ENSG00000164733
Uniprot IDs		J3KP39 Q9BPY3	P07858
PDB IDs			1CSB 1GMY 1HUC 1PBH 2IPP 2PBH 3AI8 3CBJ 3CBK 3K9M 3PBH
Enriched GO Terms of Interacting Partners?		Regulation Of Metabolic Process Developmental Process Anatomical Structure Development Regulation Of Signal Transduction Platelet Activation Regulation Of Signaling Glutaminyl-tRNA Aminoacylation Osteoclast Maturation Ras Protein Signal Transduction Organelle Organization Regulation Of Cellular Component Organization Multicellular Organismal Development Peptidyl-lysine Modification Prolyl-tRNA Aminoacylation Regulation Of Cellular Process Small GTPase Mediated Signal Transduction Actin Filament-based Process Negative Regulation Of Dendritic Spine Morphogenesis Cytoskeleton Organization Ephrin Receptor Signaling Pathway Positive Regulation Of Extracellular Vesicular Exosome Assembly Glutamyl-tRNA Aminoacylation PML Body Organization Negative Regulation Of Protein Refolding Odontoblast Differentiation Regulation Of Intracellular Signal Transduction	Regulation Of Protein Metabolic Process Negative Regulation Of Catalytic Activity Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Proteolysis Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Cellular Metabolic Process Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Regulation Of Catalytic Activity Regulation Of Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Phosphorylation Positive Regulation Of Fibroblast Proliferation Regulation Of Binding Regulation Of Growth Regulation Of Cellular Process Cell Differentiation Regulation Of Phosphorus Metabolic Process Regulation Of Fibroblast Proliferation Regulation Of Protein Localization To Nucleus Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Proliferation Positive Regulation Of Binding Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Component Organization Negative Regulation Of Blood Coagulation Negative Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Coagulation Positive Regulation Of Cell Cycle Developmental Process Negative Regulation Of Wound Healing Organ Development Negative Regulation Of MAPK Cascade Response To Abiotic Stimulus Regulation Of Protein Import Into Nucleus Regulation Of Signaling Regulation Of Apoptotic Process Regulation Of Body Fluid Levels Cellular Response To Growth Factor Stimulus
Tagcloud ?			bag1 bcl2l2 bctis ccna2 comprehend deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 klk5 map2k7 microdissected ngfb ngfr ontological pappa plau scgb1d2 scgb2a1 serpinb5 serpine1 thbs1 thbs2
Tagcloud (Difference) ?			bag1 bcl2l2 bctis ccna2 comprehend deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 klk5 map2k7 microdissected ngfb ngfr ontological pappa plau scgb1d2 scgb2a1 serpinb5 serpine1 thbs1 thbs2
Tagcloud (Intersection) ?