FAM118B and ZNF746

Number of citations: 0 (PubMedID 21900206)
Data Source: BioGRID (two hybrid)

		FAM118B	ZNF746
Name		family with sequence similarity 118 member B	zinc finger protein 746
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cajal Body	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding Identical Protein Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	None	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Protein Homooligomerization Protein Heterooligomerization
Pathways		None	Generic Transcription Pathway
GWAS		No GWAS studies recorded	Amyotrophic lateral sclerosis ( 19451621 ) Multiple sclerosis ( 21833088 )
Interacting Genes		29 interacting genes: BAG5 CEP126 CEP70 CTSB FAM118A FAM20C GNB2 ING5 ITFG1 MCM3AP MED31 NGEF PDCD10 PIAS2 QARS1 RAD54L2 RASGRP2 RBM48 SDCBP SEMA5B SETDB1 SHC1 SPRED1 SUMO1 SUMO1P1 TMSB4X VIM ZNF235 ZNF746	15 interacting genes: DIABLO DUSP23 EPHA8 FAM118B FES GSK3B HMOX2 ILK MAP3K20 MAP3K7 PRKN PRKRA RPS6KA6 UBE2E3 ZNF777
Entrez ID		79607	155061
HPRD ID		07952	08099
Ensembl ID		ENSG00000197798	ENSG00000181220
Uniprot IDs		J3KP39 Q9BPY3	A0A2R8YDQ5 A0A8J9FQ52 Q6NUN9
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Protein Sumoylation PML Body Organization	Protein Kinase Activity ATP Binding Kinase Activity Protein Serine/threonine Kinase Activity Nucleotide Binding Positive Regulation Of Intracellular Signal Transduction Transferase Activity Magnesium Ion Binding Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Protein Phosphorylation Protein Autophosphorylation Protein Serine Kinase Activity P38MAPK Cascade Stress-activated MAPK Cascade MAP Kinase Kinase Kinase Activity Stress-activated Protein Kinase Signaling Cascade Negative Regulation Of Gene Expression Phosphorylation Signal Transduction In Response To DNA Damage Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Autophagy Protein Kinase Binding Protein K11-linked Ubiquitination Protein Kinase Activator Activity Regulation Of Microtubule Anchoring At Centrosome Negative Regulation Of Spontaneous Neurotransmitter Secretion Positive Regulation Of Mitotic DNA Damage Checkpoint Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein Modification Process Cytosol Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Stress Superior Temporal Gyrus Development Negative Regulation Of Type B Pancreatic Cell Development SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Biosynthetic Process Negative Regulation Of Glycogen (starch) Synthase Activity Scaffold Protein Binding Heme Oxidation Heme Oxygenase (decyclizing) Activity Positive Regulation Of Retrograde Transport, Endosome To Golgi Protein Monoubiquitination Negative Regulation Of Intralumenal Vesicle Formation