NGEF and C7orf25

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		NGEF	C7orf25
Gene Name		neuronal guanine nucleotide exchange factor	chromosome 7 open reading frame 25
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Membrane Growth Cone
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity
	Biological Process	Small GTPase Mediated Signal Transduction Axon Guidance Positive Regulation Of Rho GTPase Activity Positive Regulation Of Apoptotic Process Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Dendritic Spine Morphogenesis Apoptotic Signaling Pathway
Pathways		Signaling by GPCR Signalling by NGF Axon guidance Cell death signalling via NRAGE, NRIF and NADE p75 NTR receptor-mediated signalling Rho GTPase cycle EPHA-mediated growth cone collapse GPCR downstream signaling NRAGE signals death through JNK Signaling by Rho GTPases EPH-Ephrin signaling G alpha (12/13) signalling events
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: ATP5C1 C7orf25 C8orf33 EPHA4 FAM118B MRPL44 NUDT21 TAF1D	18 interactors: BRD4 CEP70 CRYM DACT1 EZH2 FRA10AC1 FYN FZR1 HAP1 HEXDC MTOR NGEF PTN RASSF1 RPL36AL SF3B2 TARS UBE2D1
Entrez ID		25791	79020
HPRD ID		10442	09861
Ensembl ID		ENSG00000066248	ENSG00000136197
Uniprot IDs		B4DDI2 Q8N5V2	Q9BPX7
PDB IDs
Enriched GO Terms of Interacting Partners?		DNA-templated Transcription, Termination Positive Regulation Of Rho Guanyl-nucleotide Exchange Factor Activity Fasciculation Of Motor Neuron Axon Fasciculation Of Sensory Neuron Axon Negative Regulation Of Axon Regeneration	Regulation Of Cell Cycle Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Cell Cycle Process Regulation Of Protein Metabolic Process Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cell Cycle Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Cellular Response To Stress Regulation Of Intracellular Signal Transduction Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Ubiquitination Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Protein Catabolic Process Mitotic Cell Cycle Positive Regulation Of Protein Metabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Cellular Component Organization Cellular Response To DNA Damage Stimulus Positive Regulation Of Cell Differentiation Posttranscriptional Regulation Of Gene Expression Regulation Of Cell Morphogenesis Regulation Of Protein Localization To Nucleus Regulation Of Cell Projection Organization Regulation Of Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of Protein Modification Process Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Ubiquitination Positive Regulation Of Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Differentiation Regulation Of DNA-templated Transcription, Elongation Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Division Positive Regulation Of Neurotrophin Production Regulation Of Carbohydrate Utilization Positive Regulation Of Nonmotile Primary Cilium Assembly Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Positive Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		1h aangef amide asn asp asparaginyl aspartyl backbone capillary carry ce deposited deposits deprotonation inventory isoasp isoaspartate isomerization isopeptide isotope kd2o kh2o limiting notion peptides proton succinimide validate velocity
Tagcloud (Difference) ?		1h aangef amide asn asp asparaginyl aspartyl backbone capillary carry ce deposited deposits deprotonation inventory isoasp isoaspartate isomerization isopeptide isotope kd2o kh2o limiting notion peptides proton succinimide validate velocity
Tagcloud (Intersection) ?