NGEF and TAF1D

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		NGEF	TAF1D
Description		neuronal guanine nucleotide exchange factor	TATA-box binding protein associated factor, RNA polymerase I subunit D
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane Growth Cone Cell Projection Glutamatergic Synapse	Nucleus Nucleoplasm RNA Polymerase Transcription Factor SL1 Complex Nucleolus Cytosol Centriolar Satellite Mitotic Spindle
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Ephrin Receptor Binding	DNA Binding Protein Binding Identical Protein Binding
	Biological Process	Nervous System Development Cell Differentiation Regulation Of Actin Cytoskeleton Organization Regulation Of GTPase Activity Ephrin Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Dendritic Spine Morphogenesis Regulation Of Synapse Pruning	Regulation Of DNA-templated Transcription
Pathways		NRAGE signals death through JNK EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse G alpha (12/13) signalling events RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle	SIRT1 negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination
Drugs
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Contrast sensitivity ( 24152035) Heel bone mineral density ( 28869591 30598549) Parkinson's disease ( 32201043) Pursuit maintenance gain ( 29064472) Schizophrenia ( 23974872 25056061 28991256 29483656 30285260) Sudden cardiac arrest ( 30169657) Superior temporal sulcus banks volume ( 31530798)
Interacting Genes		16 interacting genes: ATP5F1C C7orf25 C8orf33 EPHA4 FAM118B HCK LCOR MRPL44 NUDT21 RHOA SH2D1A SMO TAF1D TRIM55 TRIM63 USP7	23 interacting genes: CEP70 DDAH2 EZH2 FAF1 FAM20C FEZ1 HAP1 HSP90AB1 IMMT ING5 ITFG1 LRIF1 MCM3AP MCPH1 NGEF NHLH2 POLB PTN RPL36AL SMARCB1 TMSB4X UBE2D1 UBTF
Entrez ID		25791	79101
HPRD ID		10442	14679
Ensembl ID		ENSG00000066248	ENSG00000166012
Uniprot IDs		B4DDI2 Q8N5V2	Q9H5J8
PDB IDs
Enriched GO Terms of Interacting Partners?			Regulation Of Glucose Mediated Signaling Pathway RNA Polymerase I Core Promoter Sequence-specific DNA Binding RNA Polymerase I Preinitiation Complex Assembly Regulation Of Organelle Transport Along Microtubule Regulation Of Stem Cell Differentiation Positive Regulation Of Dendrite Development Somatic Hypermutation Of Immunoglobulin Genes Somatic Diversification Of Immune Receptors Via Somatic Mutation Protein Kinase Regulator Activity Ovulation Cycle Protein-containing Complex Regulation Of Microtubule-based Process Regulation Of Cell Communication Negative Regulation Of Stem Cell Differentiation Regulation Of Signaling Regulation Of Cell Differentiation Positive Regulation Of Cation Channel Activity Regulation Of Cellular Component Organization Regulation Of Signal Transduction Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase I Regulation Of Organelle Organization Growth Cone Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Neuron Projection Development Hepatocyte Homeostasis Positive Regulation Of Cell Projection Organization Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Somatic Diversification Of Immunoglobulins Positive Regulation Of Bone Mineralization Regulation Of Transcription By RNA Polymerase I Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Positive Regulation Of Ion Transmembrane Transporter Activity Actin Monomer Sequestering Activity Positive Regulation Of Transporter Activity Positive Regulation Of Neurotrophin Production Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion Gamma-tubulin Binding Nucleoplasm Regulation Of Neuron Projection Development Cellular Response To Trichostatin A Regulation Of Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Cell Projection Organization HSP90-CDC37 Chaperone Complex Hypothalamus Gonadotrophin-releasing Hormone Neuron Development System Development Immunoglobulin Heavy Chain V-D-J Recombination Positive Regulation Of Ossification
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