NGEF and SEPTIN2

		NGEF	SEPTIN2
Description		neuronal guanine nucleotide exchange factor	septin 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane Growth Cone Cell Projection Glutamatergic Synapse	Chromosome, Centromeric Region Kinetochore Nucleus Nucleoplasm Chromosome Cytoplasm Spindle Cytoskeleton Plasma Membrane Cilium Axoneme Cell Cortex Septin Ring Cell Surface Actin Cytoskeleton Microtubule Cytoskeleton Membrane Midbody Septin Complex Motile Cilium Cell Division Site Cleavage Furrow Photoreceptor Connecting Cilium Ciliary Transition Zone Cell Projection Intercellular Bridge Synapse Ciliary Membrane Extracellular Exosome Sperm Annulus Non-motile Cilium
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Ephrin Receptor Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Enzyme Regulator Activity Identical Protein Binding Cadherin Binding Molecular Adaptor Activity
	Biological Process	Nervous System Development Cell Differentiation Regulation Of Actin Cytoskeleton Organization Regulation Of GTPase Activity Ephrin Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Dendritic Spine Morphogenesis Regulation Of Synapse Pruning	Regulation Of L-glutamate Import Across Plasma Membrane Smoothened Signaling Pathway Spermatogenesis Intracellular Protein Localization Cell Differentiation Regulation Of Protein Localization Cell Division Cilium Assembly Cytoskeleton-dependent Cytokinesis
Pathways		NRAGE signals death through JNK EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse G alpha (12/13) signalling events RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle	Anchoring of the basal body to the plasma membrane
Drugs
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Contrast sensitivity ( 24152035) Heel bone mineral density ( 28869591 30598549) Parkinson's disease ( 32201043) Pursuit maintenance gain ( 29064472) Schizophrenia ( 23974872 25056061 28991256 29483656 30285260) Sudden cardiac arrest ( 30169657) Superior temporal sulcus banks volume ( 31530798)	Liver enzyme levels (alkaline phosphatase) ( 33972514)
Interacting Genes		16 interacting genes: ATP5F1C C7orf25 C8orf33 EPHA4 FAM118B HCK LCOR MRPL44 NUDT21 RHOA SH2D1A SMO TAF1D TRIM55 TRIM63 USP7	25 interacting genes: ATP6V0D2 BAZ2B CDC42 CEBPA COG4 CSNK2A1 DAZAP2 DSCAM ESR1 FXR1 JPT2 MTOR PIK3R2 PLEKHF2 RNF31 S100A4 SEPTIN5 SEPTIN6 SEPTIN9 SH3KBP1 SNCA STMN1 STX1A TBC1D21 UBL5
Entrez ID		25791	4735
HPRD ID		10442	03297
Ensembl ID		ENSG00000066248	ENSG00000168385
Uniprot IDs		B4DDI2 Q8N5V2	A0A384N6H6 B5MCX3 Q15019
PDB IDs			2QA5 2QAG 2QNR 6UPA 6UPQ 6UPR 7M6J
Enriched GO Terms of Interacting Partners?			Cell Division Site Septin Ring Septin Complex Identical Protein Binding Organelle Organization Regulation Of Stress Fiber Assembly Cytoskeleton-dependent Cytokinesis Regulation Of Autophagy Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Regulation Of Protein-containing Complex Assembly Synaptic Vesicle Positive Regulation Of Cell Growth Regulation Of Intracellular Signal Transduction Cell Differentiation Golgi Transport Complex Protein Destabilization Regulation Of Cytoskeleton Organization SNARE Complex Assembly Neuron Projection Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Catabolic Process Molecular Adaptor Activity Intracellular Protein Localization Negative Regulation Of Microtubule Polymerization Regulation Of Cell Communication Regulation Of Signaling Regulation Of Macroautophagy Regulation Of Signal Transduction Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Regulation Of Neurotransmitter Secretion Regulation Of Organelle Organization Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Neurotransmitter Secretion Regulation Of Cell Projection Assembly Regulation Of Cell Projection Organization Positive Regulation Of Growth Regulation Of Actin Filament Organization Cellular Developmental Process Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Cellular Component Organization Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Protein-containing Complex Negative Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Negative Regulation Of Protein-containing Complex Assembly Synaptic Vesicle Exocytosis Positive Regulation Of Protein Targeting To Mitochondrion
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