NGEF and TTK

		NGEF	TTK
Description		neuronal guanine nucleotide exchange factor	TTK protein kinase
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane Growth Cone Cell Projection Glutamatergic Synapse	Kinetochore Nucleus Cytoplasm Spindle Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Ephrin Receptor Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Kinetochore Binding Protein Serine Kinase Activity
	Biological Process	Nervous System Development Cell Differentiation Regulation Of Actin Cytoskeleton Organization Regulation Of GTPase Activity Ephrin Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Dendritic Spine Morphogenesis Regulation Of Synapse Pruning	Nuclear Division Spindle Organization Mitotic Spindle Organization Chromosome Segregation Mitotic Spindle Assembly Checkpoint Signaling Positive Regulation Of Cell Population Proliferation Female Meiosis Chromosome Segregation Meiotic Spindle Assembly Checkpoint Signaling Protein Localization To Kinetochore Protein Localization To Chromosome Positive Regulation Of SMAD Protein Signal Transduction Nuclear Chromosome Segregation Repair Of Mitotic Kinetochore Microtubule Attachment Defect Protein Localization To Meiotic Spindle Midzone
Pathways		NRAGE signals death through JNK EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse G alpha (12/13) signalling events RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs			Pyrazolanthrone Fostamatinib BOS172722
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Contrast sensitivity ( 24152035) Heel bone mineral density ( 28869591 30598549) Parkinson's disease ( 32201043) Pursuit maintenance gain ( 29064472) Schizophrenia ( 23974872 25056061 28991256 29483656 30285260) Sudden cardiac arrest ( 30169657) Superior temporal sulcus banks volume ( 31530798)	Daytime sleep phenotypes ( 27126917) Macular thickness ( 30535121)
Interacting Genes		16 interacting genes: ATP5F1C C7orf25 C8orf33 EPHA4 FAM118B HCK LCOR MRPL44 NUDT21 RHOA SH2D1A SMO TAF1D TRIM55 TRIM63 USP7	14 interacting genes: APP AZU1 CDCA8 CDK2 HSP90AA1 KNL1 MAPK6 POLR2A RAD52 RPS6KA1 TP53 TUBB TUBB1 USP16
Entrez ID		25791	7272
HPRD ID		10442	04973
Ensembl ID		ENSG00000066248	ENSG00000112742
Uniprot IDs		B4DDI2 Q8N5V2	P33981
PDB IDs			2X9E 2ZMC 2ZMD 3CEK 3DBQ 3GFW 3H9F 3HMN 3HMO 3HMP 3VQU 3W1F 3WYX 3WYY 3WZJ 3WZK 4B94 4BHZ 4BI0 4BI1 4BI2 4C4E 4C4F 4C4G 4C4H 4C4I 4C4J 4CV8 4CV9 4CVA 4D2S 4H7X 4H7Y 4JS8 4JT3 4O6L 4ZEG 5AP0 5AP1 5AP2 5AP3 5AP4 5AP5 5AP6 5AP7 5EH0 5EHL 5EHO 5EHY 5EI2 5EI6 5EI8 5LJJ 5MRB 5N7V 5N84 5N87 5N93 5N9S 5NA0 5NAD 5NTT 5O91 6B4W 6GVJ 6H3K 6N6O 6TN9 6TNB 6TNC 6TND 7CHM 7CHN 7CHT 7CIL 7CJA 7CLH 7LQD
Enriched GO Terms of Interacting Partners?			Protein-containing Complex Regulation Of Chromosome Organization Regulation Of Cellular Component Organization Cellular Component Assembly Mitotic Cell Cycle Chromosome Organization Cell Division Nuclear Envelope Lumen Protein Tetramerization Regulation Of Mitotic Cell Cycle Cardiac Muscle Cell Apoptotic Process Striated Muscle Cell Apoptotic Process Spindle Assembly Intercellular Bridge Membraneless Organelle Assembly Mitotic G1 DNA Damage Checkpoint Signaling Mitotic G1/S Transition Checkpoint Signaling Heparan Sulfate Proteoglycan Binding Ubiquitin Protein Ligase Binding Response To Salt Stress Muscle Cell Apoptotic Process Positive Regulation Of Cell Cycle Checkpoint Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Molecular Function Activator Activity Disordered Domain Specific Binding Organelle Assembly Ephrin Receptor Binding Microglial Cell Activation Immune Effector Process Regulation Of Organelle Organization Positive Regulation Of Gene Expression Cytoplasm Spindle Organization Leukocyte Activation Involved In Inflammatory Response Nucleoplasm Protein-containing Complex Assembly Microtubule-based Process Response To Antibiotic Mitotic Sister Chromatid Segregation Regulation Of Cell Cycle Phase Transition Positive Regulation Of Nitric Oxide Biosynthetic Process Organelle Organization Sister Chromatid Segregation Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Amyloid-beta Complex Growth Cone Lamellipodium Protein-containing Complex Organization
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