NGEF and ATP5C1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		NGEF	ATP5C1
Gene Name		neuronal guanine nucleotide exchange factor	ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Membrane Growth Cone	Mitochondrial Proton-transporting ATP Synthase Complex, Catalytic Core F(1) Mitochondrion Mitochondrial Inner Membrane Mitochondrial Proton-transporting ATP Synthase Complex Mitochondrial Matrix Membrane Extracellular Vesicular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity	ATPase Activity Transmembrane Transporter Activity Poly(A) RNA Binding Proton-transporting ATP Synthase Activity, Rotational Mechanism Proton-transporting ATPase Activity, Rotational Mechanism
	Biological Process	Small GTPase Mediated Signal Transduction Axon Guidance Positive Regulation Of Rho GTPase Activity Positive Regulation Of Apoptotic Process Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Dendritic Spine Morphogenesis Apoptotic Signaling Pathway	Oxidative Phosphorylation ATP Biosynthetic Process Respiratory Electron Transport Chain Mitochondrial ATP Synthesis Coupled Proton Transport Cellular Metabolic Process Small Molecule Metabolic Process
Pathways		Signaling by GPCR Signalling by NGF Axon guidance Cell death signalling via NRAGE, NRIF and NADE p75 NTR receptor-mediated signalling Rho GTPase cycle EPHA-mediated growth cone collapse GPCR downstream signaling NRAGE signals death through JNK Signaling by Rho GTPases EPH-Ephrin signaling G alpha (12/13) signalling events	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. The citric acid (TCA) cycle and respiratory electron transport Formation of ATP by chemiosmotic coupling
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: ATP5C1 C7orf25 C8orf33 EPHA4 FAM118B MRPL44 NUDT21 TAF1D	23 interactors: APP ATP5A1 ATP5B CA12 CCND3 CCT7 CHMP2B DPP3 EGFR ELOF1 GDPD2 ITIH2 MED15 MPP1 NDUFB3 NGEF PAWR PJA1 PNO1 POLA2 PTN SERPINA1 ZNF337
Entrez ID		25791	509
HPRD ID		10442	00156
Ensembl ID		ENSG00000066248	ENSG00000165629
Uniprot IDs		B4DDI2 Q8N5V2	P36542 Q8TAS0
PDB IDs
Enriched GO Terms of Interacting Partners?		DNA-templated Transcription, Termination Positive Regulation Of Rho Guanyl-nucleotide Exchange Factor Activity Fasciculation Of Motor Neuron Axon Fasciculation Of Sensory Neuron Axon Negative Regulation Of Axon Regeneration	Mitochondrial ATP Synthesis Coupled Proton Transport Respiratory Electron Transport Chain Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Electron Transport Chain ATP Metabolic Process ATP Synthesis Coupled Proton Transport Cellular Respiration ATP Biosynthetic Process Alkanesulfonate Metabolic Process Response To Methanol Purine Nucleoside Metabolic Process Ion Homeostasis Nucleotide Metabolic Process Negative Regulation Of Endopeptidase Activity Learning Or Memory Negative Regulation Of Peptidase Activity ATP Hydrolysis Coupled Proton Transport Synaptic Growth At Neuromuscular Junction Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process Response To Triglyceride Astrocyte Activation Platelet Degranulation Purine Ribonucleoside Monophosphate Biosynthetic Process Ossification Positive Regulation Of Cell Cycle Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cognition Ribonucleotide Metabolic Process Nucleoside Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Nucleobase-containing Small Molecule Metabolic Process Purine Nucleotide Metabolic Process Regulation Of ERBB Signaling Pathway Negative Regulation Of Dendritic Spine Morphogenesis Collateral Sprouting In Absence Of Injury Nucleoside Triphosphate Biosynthetic Process Ribose Phosphate Metabolic Process Cell Activation Ribonucleoside Monophosphate Biosynthetic Process Small Molecule Metabolic Process Activation Of Phospholipase A2 Activity Response To Chromate Negative Regulation Of Proteolysis Cellular Metabolic Process Regulation Of Catalytic Activity Nucleobase-containing Compound Metabolic Process Nucleoside Monophosphate Biosynthetic Process Negative Regulation Of Protein Processing Cellular Localization
Tagcloud ?		1h aangef amide asn asp asparaginyl aspartyl backbone capillary carry ce deposited deposits deprotonation inventory isoasp isoaspartate isomerization isopeptide isotope kd2o kh2o limiting notion peptides proton succinimide validate velocity	3xflag compatible created creating ddost deleted dissociated envelope immunolocalization knock mammals persists phosphatases pp1 ppp1ca ppp1cb ppp1cc ppp1cc1 ppp1cc2 reciprocal sbp sedimentation spermatogenesis spermatogenic splice tagged tandem testis ubiquitously
Tagcloud (Difference) ?		1h aangef amide asn asp asparaginyl aspartyl backbone capillary carry ce deposited deposits deprotonation inventory isoasp isoaspartate isomerization isopeptide isotope kd2o kh2o limiting notion peptides proton succinimide validate velocity	3xflag compatible created creating ddost deleted dissociated envelope immunolocalization knock mammals persists phosphatases pp1 ppp1ca ppp1cb ppp1cc ppp1cc1 ppp1cc2 reciprocal sbp sedimentation spermatogenesis spermatogenic splice tagged tandem testis ubiquitously
Tagcloud (Intersection) ?