NGEF and C8orf33

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		NGEF	C8orf33
Gene Name		neuronal guanine nucleotide exchange factor	chromosome 8 open reading frame 33
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Membrane Growth Cone
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity
	Biological Process	Small GTPase Mediated Signal Transduction Axon Guidance Positive Regulation Of Rho GTPase Activity Positive Regulation Of Apoptotic Process Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Dendritic Spine Morphogenesis Apoptotic Signaling Pathway
Pathways		Signaling by GPCR Signalling by NGF Axon guidance Cell death signalling via NRAGE, NRIF and NADE p75 NTR receptor-mediated signalling Rho GTPase cycle EPHA-mediated growth cone collapse GPCR downstream signaling NRAGE signals death through JNK Signaling by Rho GTPases EPH-Ephrin signaling G alpha (12/13) signalling events
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: ATP5C1 C7orf25 C8orf33 EPHA4 FAM118B MRPL44 NUDT21 TAF1D	41 interactors: AAMP ALAS1 APP BLOC1S2 BRD4 CEP70 CRELD2 DVL3 EDRF1 EPS8 FAM9B FEZ1 FST FYN GIT1 GPRASP1 HAP1 HMBOX1 IKZF1 IMMT KBTBD7 KCTD6 KRTAP10-7 LZTS2 MDFI MRFAP1 NGEF NOL7 PI4KA PNMA1 RASSF1 SF3B2 TAOK1 TRIM23 TUBA1A TUBB2B WIZ ZC3H15 ZFP28 ZNF205 ZNF331
Entrez ID		25791	65265
HPRD ID		10442	07951
Ensembl ID		ENSG00000066248	ENSG00000182307
Uniprot IDs		B4DDI2 Q8N5V2	Q9H7E9
PDB IDs
Enriched GO Terms of Interacting Partners?		DNA-templated Transcription, Termination Positive Regulation Of Rho Guanyl-nucleotide Exchange Factor Activity Fasciculation Of Motor Neuron Axon Fasciculation Of Sensory Neuron Axon Negative Regulation Of Axon Regeneration	Cell Cycle Regulation Of Signal Transduction Movement Of Cell Or Subcellular Component Positive Regulation Of Metabolic Process Cytoskeleton-dependent Intracellular Transport Regulation Of Signaling Axon Cargo Transport Regulation Of Cell Cycle Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Mitotic Cell Cycle Cell Cycle Process Positive Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Axon Guidance Positive Regulation Of Cell Cycle Process Locomotion Positive Regulation Of Signal Transduction Ephrin Receptor Signaling Pathway Regulation Of Cellular Process Regulation Of Cell Morphogenesis Protein Polymerization Regulation Of Metabolic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of JNK Cascade Positive Regulation Of Cell Cycle Microtubule-based Process Anterograde Axon Cargo Transport Positive Regulation Of Intracellular Signal Transduction Cellular Response To Stimulus Axonogenesis Microtubule-based Transport Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Neuron Projection Development Intracellular Signal Transduction Cell Projection Organization Axon Development Cell Morphogenesis Involved In Neuron Differentiation System Development Cellular Protein Complex Assembly Generation Of Neurons Positive Regulation Of Neutrophil Differentiation Positive Regulation Of Neurotrophin Production Positive Regulation Of Nonmotile Primary Cilium Assembly Positive Regulation Of Hydrogen Peroxide Biosynthetic Process Signal Transduction Chemotaxis Enzyme Linked Receptor Protein Signaling Pathway
Tagcloud ?		1h aangef amide asn asp asparaginyl aspartyl backbone capillary carry ce deposited deposits deprotonation inventory isoasp isoaspartate isomerization isopeptide isotope kd2o kh2o limiting notion peptides proton succinimide validate velocity
Tagcloud (Difference) ?		1h aangef amide asn asp asparaginyl aspartyl backbone capillary carry ce deposited deposits deprotonation inventory isoasp isoaspartate isomerization isopeptide isotope kd2o kh2o limiting notion peptides proton succinimide validate velocity
Tagcloud (Intersection) ?