NGEF and C8orf33

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		NGEF	C8orf33
Description		neuronal guanine nucleotide exchange factor	chromosome 8 open reading frame 33
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane Growth Cone Cell Projection Glutamatergic Synapse
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Ephrin Receptor Binding	Protein Binding
	Biological Process	Nervous System Development Cell Differentiation Regulation Of Actin Cytoskeleton Organization Regulation Of GTPase Activity Ephrin Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Dendritic Spine Morphogenesis Regulation Of Synapse Pruning
Pathways		NRAGE signals death through JNK EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse G alpha (12/13) signalling events RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Contrast sensitivity ( 24152035) Heel bone mineral density ( 28869591 30598549) Parkinson's disease ( 32201043) Pursuit maintenance gain ( 29064472) Schizophrenia ( 23974872 25056061 28991256 29483656 30285260) Sudden cardiac arrest ( 30169657) Superior temporal sulcus banks volume ( 31530798)
Interacting Genes		16 interacting genes: ATP5F1C C7orf25 C8orf33 EPHA4 FAM118B HCK LCOR MRPL44 NUDT21 RHOA SH2D1A SMO TAF1D TRIM55 TRIM63 USP7	50 interacting genes: AAMP ALAS1 APP BLOC1S2 BRD4 CEP70 CFTR CRELD2 DISC1 DVL3 EDRF1 EPS8 FAM9B FEZ1 FST FYN GIT1 GPRASP1 HAP1 HMBOX1 IKZF1 IMMT KBTBD7 KCTD6 KRTAP10-7 LZTS2 MAPK8IP2 MCC MDFI MRFAP1 NACC1 NGEF NOL7 PI4KA PICK1 PNMA1 RASSF1 SF3B2 TAOK1 TNIP1 TRIM23 TRIM41 TUBA1A TUBB2B WIZ ZC3H15 ZFP28 ZNF205 ZNF331 ZNF526
Entrez ID		25791	65265
HPRD ID		10442	07951
Ensembl ID		ENSG00000066248	ENSG00000182307
Uniprot IDs		B4DDI2 Q8N5V2	Q9H7E9
PDB IDs
Enriched GO Terms of Interacting Partners?			Cytoplasm Growth Cone Gamma-tubulin Binding Identical Protein Binding Protein Binding Regulation Of JNK Cascade Modulation Of Chemical Synaptic Transmission Ephrin Receptor Binding Negative Regulation Of Signaling Learning Growth Factor Receptor Binding Regulation Of Cell Communication Nucleus Negative Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Cell Projection Organization Postsynaptic Density Protein-containing Complex Binding Centrosome Regulation Of Cell Projection Organization Negative Regulation Of Signal Transduction Regulation Of Signal Transduction Neuron Projection Organization Regulation Of Organelle Transport Along Microtubule Positive Regulation Of Cellular Component Organization Ephrin Receptor Signaling Pathway Dendritic Spine Maintenance Microtubule Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Dendritic Spine Maintenance Cytosol Golgi-associated Vesicle Membrane Regulation Of Postsynapse Organization Neuron Cellular Homeostasis Regulation Of Cytoskeleton Organization Neuron Migration Microtubule Cytoskeleton Cell Projection Organization Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Neuron Projection Development Cellular Component Maintenance Regulation Of Microtubule-based Process Learning Or Memory Heparan Sulfate Proteoglycan Binding
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