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GCC1 and ITSN1
Number of citations of the paper that reports this interaction (PMID
22558309
)
5
Data Source:
BioGRID
(two hybrid)
GCC1
ITSN1
Gene Name
GRIP and coiled-coil domain containing 1
intersectin 1 (SH3 domain protein)
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Golgi Membrane
Cytoplasm
Golgi Apparatus
Plasma Membrane
Cytosol
Plasma Membrane
Coated Pit
Lamellipodium
Cell Junction
Endocytic Vesicle
Neuron Projection
Synapse
Molecular Function
Protein Binding
Guanyl-nucleotide Exchange Factor Activity
Rho Guanyl-nucleotide Exchange Factor Activity
Calcium Ion Binding
Protein Binding
Kinase Activator Activity
Protein Complex Scaffold
Proline-rich Region Binding
Biological Process
Protein Targeting To Golgi
Small GTPase Mediated Signal Transduction
Axon Guidance
Positive Regulation Of Rho GTPase Activity
Positive Regulation Of Phosphorylation
Positive Regulation Of Apoptotic Process
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of GTPase Activity
Neurotrophin TRK Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Synaptic Vesicle Endocytosis
Regulation Of Small GTPase Mediated Signal Transduction
Positive Regulation Of Protein Kinase B Signaling
Apoptotic Signaling Pathway
Pathways
Signaling by GPCR
Signalling by NGF
Axon guidance
Cell death signalling via NRAGE, NRIF and NADE
p75 NTR receptor-mediated signalling
Rho GTPase cycle
EPHB-mediated forward signaling
GPCR downstream signaling
NRAGE signals death through JNK
Signaling by Rho GTPases
EPH-Ephrin signaling
G alpha (12/13) signalling events
Drugs
Diseases
GWAS
Type 2 diabetes (
22158537
)
Protein-Protein Interactions
36 interactors:
ABI2
AMOTL2
APP
ARL1
ATF4
ATN1
BIRC2
BRCA1
C1orf94
CCDC85B
CEP57
CEP70
COIL
CPSF7
DNAJA3
FBF1
GLI1
GOLGA2
GTF2I
IKBKG
ITSN1
KIAA0753
KIAA1217
LZTS2
MCRS1
NAB2
NAV1
NECAB2
NINL
OIP5
PAK7
SMARCD1
TFIP11
TRIM29
USHBP1
ZNF276
82 interactors:
AGFG1
AGFG2
AP2B1
ARF6
ARFIP2
ARHGAP31
ASAP2
CCNO
CDC42
CEP85L
CLIP2
CLTC
CSNK2B
CYTH1
DAB2
DES
DISC1
DLGAP1
DNM1
DNM2
EEF1A1
EPHB2
EPN2
EPS15
EPS15L1
FCHSD2
FNBP1
FNBP4
GAREML
GCC1
GOLGA5
HIP1
HRAS
ITSN2
KHDRBS1
KIF16B
KIF5A
LMO4
MAPK6
MAPK8IP2
MRPL20
MTUS2
PACSIN3
PDCD6IP
PFDN5
PICALM
PIK3AP1
PIK3C2B
PIK3R1
PLK1
PPFIA2
PPL
PREX1
RAB11FIP2
RAB5A
RABEP1
RAI14
RNF40
RPS6KA5
SCAMP1
SCOC
SF3B4
SH3GL2
SMARCC2
SNAP23
SNAP25
SNX5
SOS1
SPDL1
SPRY2
STON2
SYNJ1
SYNJ2
TK1
TRIM8
TSG101
UBE2K
UNC119
WASL
WBP11
ZAK
ZFPM2
Entrez ID
79571
6453
HPRD ID
07599
03898
Ensembl ID
ENSG00000179562
ENSG00000205726
Uniprot IDs
A4D0Z4
Q96CN9
A7XZY7
F8W7U0
Q15811
Q6PD56
PDB IDs
1KI1
2KGR
2KHN
3FIA
3QBV
4IIM
Enriched GO Terms of Interacting Partners
?
Apoptotic Process
Programmed Cell Death
Cell Death
Death
Organelle Organization
Transcription, DNA-templated
RNA Metabolic Process
Regulation Of Transcription, DNA-templated
RNA Biosynthetic Process
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Gene Expression
Nucleobase-containing Compound Metabolic Process
Cellular Macromolecule Biosynthetic Process
Intracellular Signal Transduction
Macromolecule Biosynthetic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Regulation Of Gene Expression
Anatomical Structure Development
Developmental Process
Regulation Of Nitrogen Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Toxin Metabolic Process
Negative Regulation Of Cell Death
Mitotic Cell Cycle
Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Transcription From RNA Polymerase III Promoter
Nitrogen Compound Metabolic Process
G2/M Transition Of Mitotic Cell Cycle
Positive Regulation Of Protein Ubiquitination
Cell Communication
Positive Regulation Vascular Endothelial Growth Factor Production
Signal Transduction
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
System Development
Multicellular Organismal Development
Cellular Process
NIK/NF-kappaB Signaling
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Biosynthetic Process
Cell Cycle
Positive Regulation Of Histone H4-K20 Methylation
Spliceosomal Complex Disassembly
Positive Regulation Of Histone H4-K16 Acetylation
Positive Regulation Of Protein K63-linked Ubiquitination
Positive Regulation Of Protein Monoubiquitination
Positive Regulation Of Protein K48-linked Ubiquitination
Vesicle-mediated Transport
Endocytosis
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Regulation Of Endocytosis
Vesicle Organization
Cellular Localization
Establishment Of Localization In Cell
Regulation Of Vesicle-mediated Transport
Signaling
Synaptic Transmission
Regulation Of Cellular Component Organization
Establishment Of Organelle Localization
Cell Communication
Regulation Of Signaling
Organelle Organization
Protein Localization
Cell Differentiation
Synaptic Vesicle Transport
Cell-cell Signaling
Membrane Budding
Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Organelle Localization
Regulation Of ERBB Signaling Pathway
Positive Regulation Of Metabolic Process
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Neuron Projection Morphogenesis
Negative Regulation Of ERBB Signaling Pathway
Post-Golgi Vesicle-mediated Transport
Establishment Of Vesicle Localization
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Vesicle Localization
Transport
Cell Morphogenesis Involved In Neuron Differentiation
Axon Guidance
Generation Of Neurons
Cell Morphogenesis Involved In Differentiation
Membrane Organization
Cell Projection Morphogenesis
Cell Part Morphogenesis
Establishment Of Protein Localization
Cell Projection Organization
Synaptic Vesicle Recycling
Axonogenesis
Cellular Protein Complex Assembly
Neurogenesis
Regulation Of Catalytic Activity
Regulation Of Signal Transduction
Intracellular Transport
Cell Morphogenesis
Tagcloud
?
cbr1
david
degs
downloaded
dyrk1a
egr1
encyclopedia
geo
gse
hmgn1
hypergeometric
interrogate
kegg
kyoto
macromolecular
multiarray
mycmax
mzf1
nfe2
nfy
olf1
ominibus
pax5
rma
rp58
son
srebp1
tmem50b
ttc3
Tagcloud (Difference)
?
cbr1
david
degs
downloaded
dyrk1a
egr1
encyclopedia
geo
gse
hmgn1
hypergeometric
interrogate
kegg
kyoto
macromolecular
multiarray
mycmax
mzf1
nfe2
nfy
olf1
ominibus
pax5
rma
rp58
son
srebp1
tmem50b
ttc3
Tagcloud (Intersection)
?