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GCC1 and ATF4
Number of citations of the paper that reports this interaction (PMID
25416956
)
0
Data Source:
BioGRID
(two hybrid)
GCC1
ATF4
Gene Name
GRIP and coiled-coil domain containing 1
activating transcription factor 4
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Golgi Membrane
Cytoplasm
Golgi Apparatus
Plasma Membrane
Nucleus
Nucleoplasm
Cytoplasm
Microtubule Organizing Center
Dendrite Membrane
Nuclear Periphery
Neuron Projection
Lewy Body Core
ATF1-ATF4 Transcription Factor Complex
Molecular Function
Protein Binding
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding
Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity
Core Promoter Sequence-specific DNA Binding
RNA Polymerase II Transcription Factor Binding Transcription Factor Activity
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription
DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
Protein Binding
Protein C-terminus Binding
Sequence-specific DNA Binding
Transcription Regulatory Region DNA Binding
Biological Process
Protein Targeting To Golgi
Gluconeogenesis
Regulation Of Transcription, DNA-templated
Transcription From RNA Polymerase II Promoter
Cellular Amino Acid Metabolic Process
Activation Of Signaling Protein Activity Involved In Unfolded Protein Response
Gamma-aminobutyric Acid Signaling Pathway
Positive Regulation Vascular Endothelial Growth Factor Production
Endoplasmic Reticulum Unfolded Protein Response
Circadian Regulation Of Gene Expression
Response To Endoplasmic Reticulum Stress
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress
Cellular Response To Glucose Starvation
Positive Regulation Of Apoptotic Process
Negative Regulation Of Potassium Ion Transport
Positive Regulation Of Neuron Apoptotic Process
Cellular Protein Metabolic Process
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase I Promoter
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Negative Regulation Of Oxidative Stress-induced Neuron Death
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
Pathways
ATF4 activates genes
PERK regulates gene expression
ATF6-alpha activates chaperones
ATF6-alpha activates chaperone genes
Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS
Type 2 diabetes (
22158537
)
Inflammatory bowel disease (
23128233
)
Protein-Protein Interactions
36 interactors:
ABI2
AMOTL2
APP
ARL1
ATF4
ATN1
BIRC2
BRCA1
C1orf94
CCDC85B
CEP57
CEP70
COIL
CPSF7
DNAJA3
FBF1
GLI1
GOLGA2
GTF2I
IKBKG
ITSN1
KIAA0753
KIAA1217
LZTS2
MCRS1
NAB2
NAV1
NECAB2
NINL
OIP5
PAK7
SMARCD1
TFIP11
TRIM29
USHBP1
ZNF276
65 interactors:
APH1A
APP
ASB7
ATF2
ATF3
BATF
BATF2
BATF3
BFSP2
BTRC
CCDC106
CEBPA
CEBPB
CEBPE
CEBPG
CKAP4
CREB3
CREBZF
DAPK3
DDIT3
DISC1
EGLN3
FOS
FOSL1
GABBR2
GCC1
GOLGA1
GOLGA8EP
GOLGA8F
GPS2
GTF2A1L
GTF2B
GTF2F2
HAUS7
HK3
JUN
JUNB
KAT2B
LDOC1
LMNB1
MAF
MAFB
MAP2K7
MDM2
MPZL2
NDC80
NEK6
NFE2
NFE2L1
NFE2L2
NFKBIA
POLR2C
PTCD3
REPS1
RPS6
SNAP29
SRA1
TBP
TGM2
TREX2
TRIB3
TRIM24
TTR
ZNF212
ZNF226
Entrez ID
79571
468
HPRD ID
07599
06817
Ensembl ID
ENSG00000179562
ENSG00000128272
Uniprot IDs
A4D0Z4
Q96CN9
P18848
Q96AQ3
PDB IDs
1CI6
Enriched GO Terms of Interacting Partners
?
Apoptotic Process
Programmed Cell Death
Cell Death
Death
Organelle Organization
Transcription, DNA-templated
RNA Metabolic Process
Regulation Of Transcription, DNA-templated
RNA Biosynthetic Process
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Gene Expression
Nucleobase-containing Compound Metabolic Process
Cellular Macromolecule Biosynthetic Process
Intracellular Signal Transduction
Macromolecule Biosynthetic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Regulation Of Gene Expression
Anatomical Structure Development
Developmental Process
Regulation Of Nitrogen Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Toxin Metabolic Process
Negative Regulation Of Cell Death
Mitotic Cell Cycle
Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Transcription From RNA Polymerase III Promoter
Nitrogen Compound Metabolic Process
G2/M Transition Of Mitotic Cell Cycle
Positive Regulation Of Protein Ubiquitination
Cell Communication
Positive Regulation Vascular Endothelial Growth Factor Production
Signal Transduction
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
System Development
Multicellular Organismal Development
Cellular Process
NIK/NF-kappaB Signaling
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Biosynthetic Process
Cell Cycle
Positive Regulation Of Histone H4-K20 Methylation
Spliceosomal Complex Disassembly
Positive Regulation Of Histone H4-K16 Acetylation
Positive Regulation Of Protein K63-linked Ubiquitination
Positive Regulation Of Protein Monoubiquitination
Positive Regulation Of Protein K48-linked Ubiquitination
Transcription From RNA Polymerase II Promoter
RNA Biosynthetic Process
Transcription, DNA-templated
RNA Metabolic Process
Gene Expression
Regulation Of RNA Biosynthetic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of RNA Metabolic Process
Positive Regulation Of Gene Expression
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of Gene Expression
Cellular Macromolecule Biosynthetic Process
Regulation Of Nitrogen Compound Metabolic Process
Macromolecule Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Cellular Biosynthetic Process
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Cellular Metabolic Process
Heterocycle Metabolic Process
Nucleobase-containing Compound Metabolic Process
Regulation Of Metabolic Process
Cellular Aromatic Compound Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Biosynthetic Process
Nitrogen Compound Metabolic Process
Cellular Response To Stress
Myeloid Cell Differentiation
Leukocyte Differentiation
Cellular Metabolic Process
Response To Stress
Apoptotic Process
Cellular Response To Organic Substance
Negative Regulation Of Biosynthetic Process
Organ Development
Myeloid Leukocyte Differentiation
Defense Response
Programmed Cell Death
Immune System Process
Response To Stimulus
Cell Death
Death
Hemopoiesis
Response To External Stimulus
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Viral Process
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Tagcloud
?
activates
anticancer
attenuated
autophagy
cebpb
chip
ddit4
depletion
effectively
elusive
exo
genomic
greatly
largely
mitochondria
mtorc1
nude
pad
pan
perturbation
potentials
remain
resolution
responsive
sesn2
triple
unveiled
xenograft
yw3
Tagcloud (Difference)
?
activates
anticancer
attenuated
autophagy
cebpb
chip
ddit4
depletion
effectively
elusive
exo
genomic
greatly
largely
mitochondria
mtorc1
nude
pad
pan
perturbation
potentials
remain
resolution
responsive
sesn2
triple
unveiled
xenograft
yw3
Tagcloud (Intersection)
?