GCC1 and FIGNL1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GCC1	FIGNL1
Description		GRIP and coiled-coil domain containing 1	fidgetin like 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Trans Cisterna Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Membrane	Nuclear Chromosome Nucleus Nucleoplasm Cytoplasm Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Protein Binding Small GTPase Binding	Nucleotide Binding Magnesium Ion Binding Protein Binding ATP Binding Microtubule Severing ATPase Activity Hydrolase Activity ATP Hydrolysis Activity Metal Ion Binding
	Biological Process		Osteoblast Differentiation Male Meiotic Nuclear Division Regulation Of Double-strand Break Repair Via Homologous Recombination Osteoblast Proliferation Negative Regulation Of Apoptotic Process ATP Metabolic Process Microtubule Severing Regulation Of Cell Cycle Cellular Response To Ionizing Radiation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Retrograde transport at the Trans-Golgi-Network	Resolution of D-loop Structures through Holliday Junction Intermediates Meiotic recombination
Drugs
Diseases
GWAS		Feeling worry ( 29500382) General cognitive ability ( 29844566) Intelligence (MTAG) ( 29326435) Medication adherence in chronic diseases ( 25317111) Refractive error ( 32231278) Type 2 diabetes ( 22158537 26818947 30718926)	Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Crohn's disease ( 21102463)
Interacting Genes		66 interacting genes: ABI2 AMOTL2 APP ARL1 ATF4 ATN1 BIRC2 BRCA1 C1orf94 CCDC33 CCDC85B CEP57 CEP70 COIL CPSF7 DISC1 DNAJA3 DRC4 FAM83A FBF1 FBXO28 FIGNL1 FOSL1 GLI1 GOLGA2 GTF2I HDX ICA1L IKBKG ITSN1 KATNAL1 KDM1A KIAA0753 KIAA1217 KIF5B LCA5 LZTS2 MCRS1 MED4 MEOX1 MID2 NAB2 NAV1 NECAB2 NINL OIP5 PAK5 PPP1R18 PPP1R27 PRPF18 RUNX1 SMARCA2 SMARCD1 SPOP TFIP11 TLE5 TP53BP2 TRIM29 TRIM50 TSC1 USHBP1 UTP14C XIAP ZC4H2 ZFP90 ZNF276	7 interacting genes: DMC1 FIRRM GCC1 IDH1 ITGB1BP1 KDM1A SPIDR
Entrez ID		79571	63979
HPRD ID		07599	10958
Ensembl ID		ENSG00000179562	ENSG00000132436
Uniprot IDs		A4D0Z4 Q96CN9	B3KNH6 Q6PIW4
PDB IDs			3D8B 8R64
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Protein Binding Cytoskeleton Microtubule Centrosome Microtubule Severing Transcription Coactivator Activity Microtubule-based Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cytoplasm Regulation Of DNA Repair Microtubule Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process P53 Binding Microtubule Severing ATPase Activity Regulation Of Primary Metabolic Process Lens Fiber Cell Morphogenesis Ciliary Basal Body Regulation Of Cellular Response To Stress Regulation Of Double-strand Break Repair Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Manganese Ion Spindle Pole Cytoplasm Organization Microtubule Cytoskeleton Organization Nucleus Negative Regulation Of DNA-templated Transcription Regulation Of Growth Negative Regulation Of RNA Biosynthetic Process Spermatid Development	Nucleobase-containing Compound Metabolic Process Regulation Of Phosphorus Metabolic Process Glyoxylate Cycle Isocitrate Metabolic Process Isocitrate Dehydrogenase (NADP+) Activity Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Regulation Of Protein Modification Process Negative Regulation Of Protein Targeting To Membrane Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Recombinational Repair DNA Strand Invasion DNA Metabolic Process DNA Recombinase Assembly Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Strand Exchange Activity Chromosome Catalytic Activity, Acting On DNA Chromosome, Telomeric Region Cell Maturation Regulation Of DNA Recombination Response To Fungicide MRF Binding Regulation Of Double-strand Break Repair Guanine Metabolic Process Protein Demethylase Activity Telomeric Repeat-containing RNA Binding Cellular Response To Radiation Response To Ionizing Radiation Cellular Response To Ionizing Radiation FAD-dependent H3K4me/H3K4me3 Demethylase Activity Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Cellular Response To Camptothecin Regulation Of Phospholipid Catabolic Process Glyoxylate Metabolic Process Activation Of Protein Kinase B Activity Developmental Maturation DNA Damage Response Histone H3K4 Demethylase Activity Regulation Of Establishment Of Protein Localization To Chromosome Golgi Trans Cisterna Double-strand Break Repair Regulation Of DNA Repair Regulation Of Protein Kinase Activity DNA Recombination Double-strand Break Repair Involved In Meiotic Recombination Histone H3K9 Demethylase Activity Integrin Activation Regulation Of Kinase Activity
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