CRELD2 and LTB4R2

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		CRELD2	LTB4R2
Description		CRELD disulfide isomerase 2	leukotriene B4 receptor 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Endoplasmic Reticulum Golgi Apparatus	Nucleoplasm Plasma Membrane Membrane
	Molecular Function	Protein Disulfide Isomerase Activity Calcium Ion Binding Protein Binding Isomerase Activity	Leukotriene B4 Receptor Activity G Protein-coupled Receptor Activity Leukotriene Receptor Activity G Protein-coupled Peptide Receptor Activity
	Biological Process		Chemotaxis Signal Transduction G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Neuropeptide Signaling Pathway Keratinocyte Migration Leukotriene Signaling Pathway
Pathways			Leukotriene receptors G alpha (q) signalling events
Drugs			Amelubant Leukotriene B4
Diseases
GWAS		Acne (severe) ( 24927181)	Anorectal malformation ( 31136621) Height ( 28552196)
Interacting Genes		8 interacting genes: C8orf33 CDKN2A CHRNA4 CHRNB2 HOXA1 LTB4R2 MEST SUV39H1	46 interacting genes: AKT1 AP2M1 CANX CEBPZ CERS1 CHPT1 CNOT10 CRELD2 CSNK2B CTSA DDOST FOLR1 GJC2 GLOD4 GPR146 GPR37 HLA-A IL17RD IMP4 LAMP5 MDH1 MGLL MYO1E OBSL1 P4HTM PER1 PIGM PKD1 RPN2 SCARB1 SEC13 SGCB SLC2A1 STMN3 SV2A SYNGR2 TMED1 TMEM94 TMUB2 TSPAN3 TSPAN4 TSPAN7 TTC9B VPS25 WFS1 YIF1B
Entrez ID		79174	56413
HPRD ID		08455	16153
Ensembl ID		ENSG00000184164	ENSG00000213906
Uniprot IDs		Q6UXH1	B4E292 Q9NPC1
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Depolarization Acetylcholine Binding Behavioral Response To Nicotine Neurotransmitter Receptor Complex Acetylcholine Receptor Activity Acetylcholine-gated Monoatomic Cation-selective Channel Activity Acetylcholine-gated Channel Complex Cation Channel Complex Synaptic Transmission, Cholinergic Regulation Of Dopamine Secretion Ligand-gated Monoatomic Ion Channel Activity Neuromuscular Synaptic Transmission Extracellular Ligand-gated Monoatomic Ion Channel Activity Regulation Of Catecholamine Secretion Sensory Perception Of Pain Response To Nicotine Acetylcholine Receptor Signaling Pathway Postsynaptic Signal Transduction Response To Hypoxia Response To Decreased Oxygen Levels Cognition Excitatory Postsynaptic Potential Visual Behavior Regulation Of B Cell Proliferation Synaptic Membrane Response To Oxygen Levels Ligase Inhibitor Activity Lateral Geniculate Nucleus Development Semicircular Canal Formation Regulation Of Behavior Regulation Of Amine Transport Regulation Of Membrane Potential Regulation Of Postsynaptic Membrane Potential Abducens Nerve Formation Optokinetic Behavior Leukotriene B4 Receptor Activity Sensory Perception Positive Regulation Of Macrophage Apoptotic Process Apoptotic Process Involved In Mammary Gland Involution ENoSc Complex Leukotriene Receptor Activity Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Regulation Of B Cell Activation Senescence-associated Heterochromatin Focus Synaptic Transmission Involved In Micturition Vestibulocochlear Nerve Development Regulation Of Circadian Sleep/wake Cycle, REM Sleep Histone H3K9 Trimethyltransferase Activity Leukotriene Signaling Pathway Negative Regulation Of Protein Neddylation	Endoplasmic Reticulum Membrane Endoplasmic Reticulum Membrane Extracellular Exosome Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Vesicle Oligosaccharyltransferase Complex B
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