CRELD2 and CDKN2A

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		CRELD2	CDKN2A
Gene Name		cysteine-rich with EGF-like domains 2	cyclin-dependent kinase inhibitor 2A
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Endoplasmic Reticulum Golgi Apparatus	Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Cytosol Nuclear Body Senescence-associated Heterochromatin Focus Protein Complex
	Molecular Function	Calcium Ion Binding Protein Binding	P53 Binding DNA Binding Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Transcription Factor Binding Protein Kinase Binding Poly(A) RNA Binding NF-kappaB Binding Ubiquitin-protein Transferase Inhibitor Activity MDM2/MDM4 Family Protein Binding
	Biological Process		G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Mitotic Cell Cycle Negative Regulation Of Cell-matrix Adhesion Transcription, DNA-templated RRNA Processing Negative Regulation Of Protein Kinase Activity Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Cycle Arrest Ras Protein Signal Transduction Negative Regulation Of Cell Proliferation Apoptotic Mitochondrial Changes Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Growth Negative Regulation Of B Cell Proliferation Regulation Of Protein Stability Protein Destabilization Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Immature T Cell Proliferation In Thymus Positive Regulation Of Protein Sumoylation Positive Regulation Of Smooth Muscle Cell Apoptotic Process Senescence-associated Heterochromatin Focus Assembly Negative Regulation Of Phosphorylation Positive Regulation Of Apoptotic Process Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Protein Export From Nucleus Somatic Stem Cell Division Protein Stabilization Negative Regulation Of Ubiquitin-protein Transferase Activity Protein K63-linked Ubiquitination Positive Regulation Of Cell Cycle Arrest Cellular Senescence Replicative Senescence Regulation Of Apoptotic DNA Fragmentation Positive Regulation Of Macrophage Apoptotic Process Positive Regulation Of Cellular Senescence
Pathways			Cyclin D associated events in G1 Oxidative Stress Induced Senescence G1 Phase Cellular Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Mitotic G1-G1/S phases Cell Cycle, Mitotic Oxidative Stress Induced Senescence Cellular Senescence Oncogene Induced Senescence
Drugs
Diseases
GWAS			Abdominal aortic aneurysm ( 20622881) Breast cancer ( 23535729 20453838) Coronary artery calcification ( 23561647) Coronary heart disease ( 21626137 21971053 17554300 21378990) Endometriosis ( 23104006) Glioma ( 21531791 19578367) Intracranial aneurysm ( 18997786 20364137) Melanoma ( 21983787 19578364) Myocardial infarction ( 17478679) Myocardial infarction (early onset) ( 19198609) Platelet counts ( 22139419) Type 2 diabetes ( 21573907 18372903 20581827 19401414 17463246 17463248 17463249 23209189)
Protein-Protein Interactions		6 interactors: C8orf33 CDKN2A CHRNA4 CHRNB2 MEST SUV39H1	94 interactors: ACLY ACTB ACTG1 ACTN4 AHNAK ANKRD12 ARFIP2 BCL2L1 BECN1 CARF CCDC183 CCND1 CCND2 CCNG1 CDC45 CDC5L CDC6 CDC7 CDK4 CDK6 CDKN2AIP CDKN2C CRELD2 CTBP2 DEAF1 E2F1 E4F1 EEF2 EGR1 EPHA3 FN1 GAPDH GGA1 GGA3 GMNN GSPT1 HIF1A HIST3H2BB HNRNPA2B1 HNRNPC HNRNPU HSP90AA1 HSP90AB1 HSPA4 HSPA8 HUWE1 KAT5 MAPK10 MAPK8 MCM10 MCM2 MCM5 MCM6 MDM2 MMRN1 MTR MYC MYL12A NCL NMI ORC4 PCNA PDCD6 PEX19 PLEKHA8 PPP1R9B PRKCA PSMC3 RIN2 RPS7 RUVBL2 SERTAD1 SIVA1 SLC4A1 SMARCA4 SNRPA SNRPB TBRG1 TDRD7 TP63 TPI1 TRIP12 TUBA1A TUBA1C TUBB TUBB4B UBE2A UBE4B USP26 WRN YY1 ZFP91 ZNF227 ZNF410
Entrez ID		79174	1029
HPRD ID		08455	02542
Ensembl ID		ENSG00000184164	ENSG00000147889
Uniprot IDs		Q6UXH1	G3XAG3 K7PML8 P42771 Q8N726
PDB IDs			1A5E 1BI7 1DC2 2A5E
Enriched GO Terms of Interacting Partners?		Behavioral Response To Nicotine Synaptic Transmission, Cholinergic Regulation Of Dopamine Secretion Response To Hypoxia Response To Nicotine Regulation Of B Cell Proliferation Action Potential Sensory Perception Of Pain Regulation Of Circadian Rhythm Lateral Geniculate Nucleus Development Membrane Depolarization RRNA Processing RRNA Metabolic Process Regulation Of Anion Transport Response To Alkaloid B Cell Activation Adult Behavior Senescence-associated Heterochromatin Focus Assembly Synaptic Transmission Involved In Micturition Ribosome Biogenesis Regulation Of Cellular Localization Negative Regulation Of Action Potential Positive Regulation Of Cellular Senescence Response To Abiotic Stimulus Locomotory Behavior Positive Regulation Of Smooth Muscle Cell Apoptotic Process Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Dopamine Secretion Regulation Of Membrane Potential Negative Regulation Of Immature T Cell Proliferation In Thymus Histone H3-K9 Dimethylation Micturition Conditioned Taste Aversion Cognition Positive Regulation Of Macrophage Apoptotic Process Calcium Ion Transport Regulation Of Apoptotic DNA Fragmentation Positive Regulation Of Cell Aging Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Ribonucleoprotein Complex Biogenesis Vestibulocochlear Nerve Development Positive Regulation Of Synaptic Transmission, Dopaminergic Response To Stress Optic Nerve Morphogenesis Positive Regulation Of Myeloid Cell Apoptotic Process Negative Regulation Of T Cell Differentiation In Thymus Histone H3-K9 Trimethylation Positive Regulation Of Catecholamine Secretion Cellular Response To Stress Heterochromatin Assembly	Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Cycle Process Mitotic Cell Cycle Mitotic Cell Cycle Process Cell Cycle G1/S Transition Of Mitotic Cell Cycle Response To Stress Cellular Response To Stress Regulation Of Metabolic Process Regulation Of Cell Cycle Response To Abiotic Stimulus Cellular Response To DNA Damage Stimulus Response To Radiation Negative Regulation Of Cell Cycle Response To Light Stimulus Regulation Of Mitotic Cell Cycle Cell Division Cellular Nitrogen Compound Metabolic Process Response To UV Positive Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Organelle Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Replication DNA Replication Initiation Nitrogen Compound Metabolic Process Chromosome Organization Cellular Metabolic Process Regulation Of Cell Cycle Phase Transition Positive Regulation Of Cellular Metabolic Process DNA Metabolic Process Positive Regulation Of Cell Cycle Phase Transition Cellular Response To Radiation Regulation Of Protein Metabolic Process DNA-dependent DNA Replication Regulation Of Mitotic Cell Cycle Phase Transition Cell Cycle Checkpoint Regulation Of Cell Proliferation Cellular Macromolecule Biosynthetic Process Regulation Of Cell Cycle Process Regulation Of Cellular Protein Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Macromolecule Biosynthetic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Cellular Response To Stimulus DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation
Tagcloud ?		acidification apparatus atpase atpases baf bafilomycin bapta barely bfa brefeldin chelator cma concanamycin cos7 egfp grp78 hek293 intravesicular ionophore isomerase organelles pdi perturbation perturbed relying secretion secretory transportation vacuolar	a134c abp allelic ankyrin balb cdk6 cdnas chr congenic d2 dba g232a ifna inbred inefficient ink4c le multigenic mus p15 p16 p18 pctr1 plasmacytoma pristane spretus typed
Tagcloud (Difference) ?		acidification apparatus atpase atpases baf bafilomycin bapta barely bfa brefeldin chelator cma concanamycin cos7 egfp grp78 hek293 intravesicular ionophore isomerase organelles pdi perturbation perturbed relying secretion secretory transportation vacuolar	a134c abp allelic ankyrin balb cdk6 cdnas chr congenic d2 dba g232a ifna inbred inefficient ink4c le multigenic mus p15 p16 p18 pctr1 plasmacytoma pristane spretus typed
Tagcloud (Intersection) ?