APOA1 and LCAT

Number of citations of the paper that reports this interaction (PMID 1644835)
3

Data Source:
HPRD (in vivo)

		APOA1	LCAT
Gene Name		apolipoprotein A-I	lecithin-cholesterol acyltransferase
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Early Endosome Endoplasmic Reticulum Lumen Cytosol Plasma Membrane Cell Surface Endocytic Vesicle Cytoplasmic Vesicle Vesicle Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Discoidal High-density Lipoprotein Particle Spherical High-density Lipoprotein Particle Secretory Granule Lumen Chylomicron Extracellular Vesicular Exosome Endocytic Vesicle Lumen Blood Microparticle	Extracellular Region Extracellular Space High-density Lipoprotein Particle Extracellular Vesicular Exosome
	Molecular Function	Beta-amyloid Binding Protein Binding Phospholipid Binding Phospholipid Transporter Activity High-density Lipoprotein Particle Binding Cholesterol Binding Cholesterol Transporter Activity Enzyme Binding Phosphatidylcholine Binding Apolipoprotein Receptor Binding Apolipoprotein A-I Receptor Binding Identical Protein Binding Chemorepellent Activity Lipase Inhibitor Activity Phosphatidylcholine-sterol O-acyltransferase Activator Activity High-density Lipoprotein Particle Receptor Binding	Phosphatidylcholine-sterol O-acyltransferase Activity Protein Binding Apolipoprotein A-I Binding
	Biological Process	Retinoid Metabolic Process Regulation Of Protein Phosphorylation Endothelial Cell Proliferation Platelet Degranulation Negative Regulation Of Cytokine Secretion Involved In Immune Response Phosphatidylcholine Biosynthetic Process Cholesterol Biosynthetic Process Receptor-mediated Endocytosis Transforming Growth Factor Beta Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Response To Nutrient Blood Coagulation Phototransduction, Visible Light Cholesterol Metabolic Process Glucocorticoid Metabolic Process Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cholesterol Esterification Positive Regulation Of Triglyceride Catabolic Process Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Peripheral Nervous System Axon Regeneration Protein Oxidation Peptidyl-methionine Modification Lipid Storage Platelet Activation Regulation Of Intestinal Cholesterol Absorption Cholesterol Transport Adrenal Gland Development Organ Regeneration Neuron Projection Regeneration Regulation Of Cdc42 Protein Signal Transduction Cholesterol Efflux Phospholipid Efflux Negative Regulation Of Heterotypic Cell-cell Adhesion High-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Assembly High-density Lipoprotein Particle Clearance Positive Regulation Of Rho Protein Signal Transduction Lipoprotein Metabolic Process Lipoprotein Biosynthetic Process Response To Drug Cholesterol Homeostasis Blood Vessel Endothelial Cell Migration Response To Estrogen Reverse Cholesterol Transport Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Interleukin-1 Beta Secretion Negative Regulation Of Inflammatory Response Protein Stabilization Negative Chemotaxis Positive Regulation Of Lipoprotein Lipase Activity Positive Regulation Of Hydrolase Activity Positive Regulation Of Transferase Activity Positive Regulation Of Stress Fiber Assembly Transmembrane Transport Phospholipid Homeostasis Negative Regulation Of Lipase Activity Negative Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Response To Cytokine Stimulus Triglyceride Homeostasis ERK1 And ERK2 Cascade Cholesterol Import Positive Regulation Of Substrate Adhesion-dependent Cell Spreading	Phospholipid Metabolic Process Phosphatidylcholine Biosynthetic Process Cholesterol Metabolic Process Cholesterol Transport Very-low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Cholesterol Esterification Lipoprotein Metabolic Process Lipoprotein Biosynthetic Process Cholesterol Homeostasis Reverse Cholesterol Transport Small Molecule Metabolic Process Regulation Of High-density Lipoprotein Particle Assembly
Pathways		Lipoprotein metabolism PPARA activates gene expression Metabolism of lipids and lipoproteins ABC-family proteins mediated transport Chylomicron-mediated lipid transport Platelet degranulation Amyloids Response to elevated platelet cytosolic Ca2+ Scavenging by Class A Receptors Retinoid metabolism and transport Fatty acid, triacylglycerol, and ketone body metabolism Lipid digestion, mobilization, and transport Diseases associated with visual transduction HDL-mediated lipid transport Scavenging of heme from plasma Visual phototransduction Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Platelet activation, signaling and aggregation Scavenging by Class B Receptors ABCA transporters in lipid homeostasis	Lipoprotein metabolism HDL-mediated lipid transport Metabolism of lipids and lipoproteins Lipid digestion, mobilization, and transport
Drugs
Diseases
GWAS		Cholesterol, total ( 19060911 20686565) Coronary heart disease ( 21378990) HDL cholesterol ( 20864672 19060906 20686565) Hematological and biochemical traits ( 20139978) Hypertriglyceridemia ( 23505323) LDL cholesterol ( 18179892 20864672 19060911 20686565) Lipid metabolism phenotypes ( 22286219) Metabolite levels ( 22916037) Triglycerides ( 19074352 21909109 18193043 18193044 18193046 20864672 19060906 19060911 20139978 20686565)	Coronary heart disease ( 21347282) HDL cholesterol ( 18193043 20864672 19060906 19060910 20686565)
Protein-Protein Interactions		35 interactors: ABCA1 ABCA13 AKT2 APOA1BP APOA2 APOB APOC1 APOF APOL1 APP ATP5B CETP CFHR1 CLEC4G CMTM5 FBLN1 GPLD1 HPR JAK3 LBP LCAT MAP7D1 MAPK6 PCMT1 PDE1A PLTP PON1 SAA2 SCARB1 SPP1 TNFRSF10C TOMM20 TTR VKORC1 ZNRD1	4 interactors: A2M APOA1 APOE EXOSC10
Entrez ID		335	3931
HPRD ID		02517	06098
Ensembl ID		ENSG00000118137	ENSG00000213398
Uniprot IDs		P02647	P04180
PDB IDs		1AV1 1GW3 1GW4 1ODP 1ODQ 1ODR 2A01 3J00 3K2S 3R2P
Enriched GO Terms of Interacting Partners?		Cholesterol Metabolic Process Alcohol Metabolic Process Sterol Metabolic Process Cholesterol Transport Sterol Transport Lipid Transport Lipid Localization Steroid Metabolic Process Cholesterol Efflux Plasma Lipoprotein Particle Remodeling Regulation Of Plasma Lipoprotein Particle Levels Reverse Cholesterol Transport High-density Lipoprotein Particle Remodeling Small Molecule Metabolic Process Lipid Metabolic Process Lipoprotein Metabolic Process Cholesterol Homeostasis Sterol Homeostasis Regulation Of Cholesterol Transport Regulation Of Lipid Transport Protein-lipid Complex Assembly Lipid Homeostasis Phosphatidylcholine Metabolic Process Regulation Of Lipid Catabolic Process Glycerolipid Metabolic Process Plasma Lipoprotein Particle Clearance Phospholipid Transport Triglyceride Metabolic Process Neutral Lipid Metabolic Process Triglyceride-rich Lipoprotein Particle Remodeling Cellular Lipid Metabolic Process Phospholipid Efflux Low-density Lipoprotein Particle Remodeling Cellular Biogenic Amine Metabolic Process Transport Amine Metabolic Process Lipopolysaccharide Transport Endocytosis Regulation Of Lipid Metabolic Process Regulation Of Cholesterol Efflux Negative Regulation Of Lipid Transport Negative Regulation Of Lipid Catabolic Process Locomotion Regulation Of Phosphatidylcholine Catabolic Process Response To Lipid Chemical Homeostasis High-density Lipoprotein Particle Clearance Cell Motility Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Lipid Biosynthetic Process	High-density Lipoprotein Particle Clearance Positive Regulation Of Cholesterol Esterification High-density Lipoprotein Particle Assembly Regulation Of Cholesterol Esterification Peripheral Nervous System Axon Regeneration Phospholipid Efflux High-density Lipoprotein Particle Remodeling Protein-lipid Complex Assembly Reverse Cholesterol Transport Plasma Lipoprotein Particle Remodeling Regulation Of Inflammatory Response Positive Regulation Of Steroid Metabolic Process Cholesterol Efflux Regulation Of Cdc42 Protein Signal Transduction Plasma Lipoprotein Particle Clearance Regulation Of Cholesterol Transport Axon Regeneration Anion Homeostasis Neuron Projection Regeneration Regulation Of Plasma Lipoprotein Particle Levels Positive Regulation Of Lipid Biosynthetic Process Cholesterol Transport Sterol Transport Response To Axon Injury Platelet Degranulation Phototransduction, Visible Light Cholesterol Homeostasis Sterol Homeostasis Retinoid Metabolic Process Diterpenoid Metabolic Process Detection Of Visible Light Phospholipid Transport Regulation Of Lipid Transport Phototransduction Regulation Of Steroid Metabolic Process Response To Wounding Cellular Localization Negative Regulation Of Inflammatory Response Detection Of Light Stimulus Regulation Of Small GTPase Mediated Signal Transduction Cholesterol Metabolic Process Lipid Homeostasis Lipoprotein Biosynthetic Process Negative Regulation Of Catalytic Activity Isoprenoid Metabolic Process Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Positive Regulation Of Dendritic Spine Maintenance Negative Regulation Of Dendritic Spine Maintenance Negative Regulation Of Phospholipid Efflux Negative Regulation Of Lipid Transport Across Blood Brain Barrier
Tagcloud ?		admission atherosclerosis believed concentration consequence controls explain explanation explicable fifth genotypes hdl immediately infarction mi microg min ml myocardial nmol occured paraoxonase pon1 reside risen subfraction subgroups thrombolytic variation	abca1 apoa apoe astrocytes believed catalyzed cerebrospinal cholesteryl clearance cns deficiency discoidal ester esterification facilitating hdl hdls lipidation lipoprotein lipoproteins maturation nascent paralleled particles pathology pronounced ps1 spherical unaffected
Tagcloud (Difference) ?		admission atherosclerosis concentration consequence controls explain explanation explicable fifth genotypes immediately infarction mi microg min ml myocardial nmol occured paraoxonase pon1 reside risen subfraction subgroups thrombolytic variation	abca1 apoa apoe astrocytes catalyzed cerebrospinal cholesteryl clearance cns deficiency discoidal ester esterification facilitating hdls lipidation lipoprotein lipoproteins maturation nascent paralleled particles pathology pronounced ps1 spherical unaffected
Tagcloud (Intersection) ?		believed hdl