APOA1 and PON1

Number of citations of the paper that reports this interaction (PubMedID 16128586)
0

Data Source:
HPRD (in vitro)

		APOA1	PON1
Description		apolipoprotein A1	paraoxonase 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Early Endosome Endoplasmic Reticulum Lumen Cytosol Plasma Membrane Endocytic Vesicle Cytoplasmic Vesicle Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle High-density Lipoprotein Particle Spherical High-density Lipoprotein Particle Secretory Granule Lumen Chylomicron Extracellular Exosome Endocytic Vesicle Lumen Blood Microparticle Extracellular Vesicle	Extracellular Region Extracellular Space Endoplasmic Reticulum Membrane High-density Lipoprotein Particle Spherical High-density Lipoprotein Particle Extracellular Exosome Blood Microparticle
	Molecular Function	Amyloid-beta Binding Signaling Receptor Binding Lipid Transporter Activity Protein Binding Phospholipid Binding High-density Lipoprotein Particle Binding Lipid Binding Cholesterol Binding Enzyme Binding Heat Shock Protein Binding Apolipoprotein Receptor Binding Apolipoprotein A-I Receptor Binding Identical Protein Binding Protein Homodimerization Activity Chemorepellent Activity Receptor Ligand Activity Phosphatidylcholine-sterol O-acyltransferase Activator Activity High-density Lipoprotein Particle Receptor Binding Lipoprotein Particle Binding Cholesterol Transfer Activity	Aryldialkylphosphatase Activity Arylesterase Activity Calcium Ion Binding Phospholipid Binding Hydrolase Activity Protein Homodimerization Activity Metal Ion Binding Acyl-L-homoserine-lactone Lactonohydrolase Activity
	Biological Process	Endothelial Cell Proliferation Negative Regulation Of Cytokine Production Involved In Immune Response Lipid Metabolic Process Phospholipid Metabolic Process Phosphatidylcholine Biosynthetic Process Cholesterol Biosynthetic Process Lipid Transport Transforming Growth Factor Beta Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Steroid Metabolic Process Cholesterol Metabolic Process Glucocorticoid Metabolic Process Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cholesterol Efflux Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Protein Oxidation Peptidyl-methionine Modification Lipid Storage Regulation Of Intestinal Cholesterol Absorption Cholesterol Transport Adrenal Gland Development Regulation Of Cdc42 Protein Signal Transduction Negative Regulation Of Interleukin-1 Beta Production Cholesterol Efflux Phospholipid Efflux Negative Regulation Of Heterotypic Cell-cell Adhesion Amyloid-beta Formation High-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Assembly High-density Lipoprotein Particle Clearance Positive Regulation Of Rho Protein Signal Transduction Lipoprotein Metabolic Process Lipoprotein Biosynthetic Process Cholesterol Homeostasis Blood Vessel Endothelial Cell Migration Reverse Cholesterol Transport Negative Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Protein Stabilization Negative Chemotaxis Vitamin Transport Positive Regulation Of Stress Fiber Assembly Acylglycerol Homeostasis Phospholipid Homeostasis Negative Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Response To Cytokine Stimulus Triglyceride Homeostasis ERK1 And ERK2 Cascade Cholesterol Import Cellular Response To Lipoprotein Particle Stimulus Positive Regulation Of Cholesterol Metabolic Process Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Phospholipid Efflux Cellular Response To Amyloid-beta	Cholesterol Metabolic Process Response To Toxic Substance Positive Regulation Of Cholesterol Efflux Negative Regulation Of Plasma Lipoprotein Oxidation Carboxylic Acid Catabolic Process Organophosphate Catabolic Process Phosphatidylcholine Metabolic Process Lactone Catabolic Process
Pathways		Platelet degranulation ABC transporters in lipid homeostasis PPARA activates gene expression Scavenging of heme from plasma Scavenging by Class B Receptors Scavenging by Class B Receptors Scavenging by Class A Receptors Scavenging by Class A Receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Defective ABCA1 causes TGD Post-translational protein phosphorylation Chylomicron assembly HDL assembly Chylomicron remodeling HDL clearance HDL remodeling Heme signaling Retinoid metabolism and transport Retinoid metabolism and transport Amyloid fiber formation	Synthesis of 5-eicosatetraenoic acids Atorvastatin ADME Atorvastatin ADME
Drugs		Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Moxifloxacin Cefazolin Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Hypoalphalipoproteinemia Familial amyloidosis
GWAS		Allergic rhinitis ( 30013184) Apolipoprotein A1 levels ( 32203549) Body mass index ( 31978080) Cholesterol, total ( 19060911 20686565 24097068) Coronary artery disease ( 24262325) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 21378990) Delirium ( 29631748) Diastolic blood pressure ( 27841878) Fasting triglyceride levels ( 32603185) HDL cholesterol ( 19060906 26582766 20686565 24097068 20864672) HDL cholesterol levels ( 28334899) Hearing function ( 25060954) Hematological and biochemical traits ( 20139978) Hypertriglyceridemia ( 27599772 23505323) Infantile hypertrophic pyloric stenosis ( 23989729) LDL cholesterol ( 20864672 24097068 18179892 20686565 19060911) LDL cholesterol levels ( 28334899) Lipid metabolism phenotypes ( 22286219) Lipid traits ( 24386095) Metabolite levels ( 22916037) Postprandial triglyceride levels ( 32603185) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Systolic blood pressure ( 27841878) Total cholesterol levels ( 28334899 32759990) Total triglycerides levels ( 26690388) Triglyceride levels ( 28334899 28371326 28548082 26763881 32759990) Triglycerides ( 24097068 26582766 21909109 20864672 20686565 20139978 19074352 19060911 19060906 18193046 18193044 18193043) Very low density lipoprotein cholesterol levels ( 28548082)	HDL cholesterol levels ( 32203549) Health literacy ( 31250787) Metabolite levels ( 23281178) Response to TNF antagonist treatment ( 18615156)
Interacting Genes		38 interacting genes: ABCA1 ABCA13 AKT2 APOB APOC1 APOF APOL1 APP ATP5F1B BRAP CETP CFHR1 CLEC4G CMTM5 FBLN1 GPLD1 HPR HSP90AA1 JAK3 LBP LCAT MAP7D1 NAXE NDRG1 PCMT1 PDE1A PLTP POLR1H PON1 SCARB1 SPP1 TNFRSF10C TOMM20 TREM2 TRIM15 TTR VKORC1 VWF	5 interacting genes: ALB APOA1 CDK1 CLU PLK1
Entrez ID		335	5444
HPRD ID		02517	01351
Ensembl ID		ENSG00000118137	ENSG00000005421
Uniprot IDs		A0A024R3E3 P02647	P27169
PDB IDs		1AV1 1GW3 1GW4 1ODP 1ODQ 1ODR 2MSC 2MSD 2MSE 2N5E 3K2S 3R2P 4V6M 6CC9 6CCH 6CCX 6CLZ 6CM1 6PTS 6PTW 6W4E 6W4F 7KJR 7RSC 7RSE 8EQS	1V04
Enriched GO Terms of Interacting Partners?		High-density Lipoprotein Particle Regulation Of Lipid Transport Regulation Of Cholesterol Transport Lipid Transport Cholesterol Metabolic Process Sterol Metabolic Process Sterol Transport Steroid Metabolic Process Lipoprotein Metabolic Process Apolipoprotein A-I Binding Cholesterol Transport Positive Regulation Of Cholesterol Transport Plasma Lipoprotein Particle Remodeling Protein-containing Complex Remodeling Extracellular Space Positive Regulation Of Lipid Transport Regulation Of Cholesterol Efflux High-density Lipoprotein Particle Remodeling Extracellular Region Organic Hydroxy Compound Transport Cholesterol Efflux High-density Lipoprotein Particle Binding Alcohol Metabolic Process Lipid Metabolic Process Apolipoprotein Binding Reverse Cholesterol Transport Lipid Homeostasis Extracellular Exosome Very-low-density Lipoprotein Particle Small Molecule Metabolic Process Lipoprotein Biosynthetic Process Cholesterol Transfer Activity Positive Regulation Of Cholesterol Efflux Phosphatidylcholine Binding Positive Regulation Of Transport Phospholipid Transport Cholesterol Homeostasis Sterol Homeostasis Detection Of Molecule Of Bacterial Origin Regulation Of Lipid Storage Regulation Of Transport Low-density Lipoprotein Particle Glycerolipid Metabolic Process Lipopolysaccharide Transport Low-density Lipoprotein Particle Binding Regulation Of Lipid Catabolic Process Triglyceride Metabolic Process Phosphatidylcholine Metabolic Process Regulation Of High-density Lipoprotein Particle Assembly Organophosphate Ester Transport	Blood Microparticle Spherical High-density Lipoprotein Particle Mitotic Nuclear Membrane Disassembly Reverse Cholesterol Transport Membrane Disassembly Nuclear Membrane Disassembly Protein Localization To Site Of Double-strand Break Mitotic G2 DNA Damage Checkpoint Signaling Chromosome Condensation Spindle Microtubule ERK1 And ERK2 Cascade Regulation Of Protein Stability Regulation Of Organelle Organization Cell Cycle G2/M Phase Transition Nuclear Membrane Organization Centrosome Cycle Mitotic G2/M Transition Checkpoint G2/M Transition Of Mitotic Cell Cycle Platelet Alpha Granule Lumen Cholesterol Transport Negative Regulation Of Cell Cycle G2/M Phase Transition Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Mitotic DNA Damage Checkpoint Signaling Sterol Transport Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Microtubule Organizing Center Organization Amyloid-beta Binding Pronuclear Fusion Perinuclear Endoplasmic Reticulum Lumen Regulation Of Neuronal Signal Transduction Positive Regulation Of Protein Localization To Nucleus DNA Damage Checkpoint Signaling Protein-folding Chaperone Binding Enterobactin Binding Exogenous Protein Binding Cellular Response To Calcium Ion Starvation Receptor Ligand Activity Intracellular Signal Transduction Protein Localization To Organelle Protein Localization To Chromosome Mitotic DNA-templated DNA Replication Golgi Organization Regulation Of G2/M Transition Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Sister Chromatid Segregation Cyclin B1-CDK1 Complex Regulation Of Chromosome Segregation Membrane Organization Cyclin A1-CDK1 Complex
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