APOA1 and PDE1A

Number of citations: 0 (PubMedID 11991719)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		APOA1	PDE1A
Name		apolipoprotein A1	phosphodiesterase 1A
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Early Endosome Endoplasmic Reticulum Lumen Cytosol Plasma Membrane Endocytic Vesicle Cytoplasmic Vesicle Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle High-density Lipoprotein Particle Spherical High-density Lipoprotein Particle Secretory Granule Lumen Chylomicron Extracellular Exosome Endocytic Vesicle Lumen Blood Microparticle Extracellular Vesicle	Cytosol Neuronal Cell Body
	Molecular Function	Amyloid-beta Binding Signaling Receptor Binding Lipid Transporter Activity Protein Binding Phospholipid Binding High-density Lipoprotein Particle Binding Lipid Binding Cholesterol Binding Enzyme Binding Heat Shock Protein Binding Apolipoprotein Receptor Binding Apolipoprotein A-I Receptor Binding Identical Protein Binding Protein Homodimerization Activity Chemorepellent Activity Receptor Ligand Activity Phosphatidylcholine-sterol O-acyltransferase Activator Activity High-density Lipoprotein Particle Receptor Binding Lipoprotein Particle Binding Cholesterol Transfer Activity	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Calmodulin-activated Dual Specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP Phosphodiesterase Activity Protein Binding Calmodulin Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity Calmodulin-activated 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	Endothelial Cell Proliferation Negative Regulation Of Cytokine Production Involved In Immune Response Lipid Metabolic Process Phospholipid Metabolic Process Phosphatidylcholine Biosynthetic Process Cholesterol Biosynthetic Process Lipid Transport Transforming Growth Factor Beta Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Steroid Metabolic Process Cholesterol Metabolic Process Glucocorticoid Metabolic Process Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cholesterol Efflux Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Protein Oxidation Peptidyl-methionine Modification Lipid Storage Regulation Of Intestinal Cholesterol Absorption Cholesterol Transport Adrenal Gland Development Regulation Of Cdc42 Protein Signal Transduction Negative Regulation Of Interleukin-1 Beta Production Cholesterol Efflux Phospholipid Efflux Negative Regulation Of Heterotypic Cell-cell Adhesion Amyloid-beta Formation High-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Assembly High-density Lipoprotein Particle Clearance Positive Regulation Of Rho Protein Signal Transduction Lipoprotein Metabolic Process Lipoprotein Biosynthetic Process Cholesterol Homeostasis Blood Vessel Endothelial Cell Migration Reverse Cholesterol Transport Negative Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Protein Stabilization Negative Chemotaxis Vitamin Transport Positive Regulation Of Stress Fiber Assembly Acylglycerol Homeostasis Phospholipid Homeostasis Negative Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Response To Cytokine Stimulus Triglyceride Homeostasis ERK1 And ERK2 Cascade Cholesterol Import Cellular Response To Lipoprotein Particle Stimulus Positive Regulation Of Cholesterol Metabolic Process Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Phospholipid Efflux Cellular Response To Amyloid-beta	Signal Transduction Regulation Of Smooth Muscle Cell Apoptotic Process CGMP Catabolic Process Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of CAMP/PKA Signal Transduction
Pathways		Platelet degranulation ABC transporters in lipid homeostasis PPARA activates gene expression Scavenging of heme from plasma Scavenging by Class B Receptors Scavenging by Class B Receptors Scavenging by Class A Receptors Scavenging by Class A Receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Defective ABCA1 causes TGD Post-translational protein phosphorylation Chylomicron assembly HDL assembly Chylomicron remodeling HDL clearance HDL remodeling Heme signaling Retinoid metabolism and transport Retinoid metabolism and transport Amyloid fiber formation	Cam-PDE 1 activation cGMP effects G alpha (s) signalling events
Drugs		Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Caffeine Nicardipine Felodipine Bepridil Trapidil
Diseases		Hypoalphalipoproteinemia Familial amyloidosis	None
GWAS		Allergic rhinitis ( 30013184 ) Apolipoprotein A1 levels ( 32203549 ) Body mass index ( 31978080 ) Cholesterol, total ( 19060911 20686565 24097068 ) Coronary artery disease ( 24262325 ) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975 ) Coronary heart disease ( 21378990 ) Delirium ( 29631748 ) Diastolic blood pressure ( 27841878 ) Fasting triglyceride levels ( 32603185 ) HDL cholesterol ( 19060906 26582766 20686565 24097068 20864672 ) HDL cholesterol levels ( 28334899 ) Hearing function ( 25060954 ) Hematological and biochemical traits ( 20139978 ) Hypertriglyceridemia ( 27599772 23505323 ) Infantile hypertrophic pyloric stenosis ( 23989729 ) LDL cholesterol ( 20864672 24097068 18179892 20686565 19060911 ) LDL cholesterol levels ( 28334899 ) Lipid metabolism phenotypes ( 22286219 ) Lipid traits ( 24386095 ) Metabolite levels ( 22916037 ) Postprandial triglyceride levels ( 32603185 ) Serum metabolite levels ( 31636271 ) Serum metabolite levels (CMS) ( 31636271 ) Systolic blood pressure ( 27841878 ) Total cholesterol levels ( 28334899 32759990 ) Total triglycerides levels ( 26690388 ) Triglyceride levels ( 28334899 28371326 28548082 26763881 32759990 ) Triglycerides ( 24097068 26582766 21909109 20864672 20686565 20139978 19074352 19060911 19060906 18193046 18193044 18193043 ) Very low density lipoprotein cholesterol levels ( 28548082 )	Alzheimer's disease in APOE e4+ carriers ( 25778476 ) Appendicular lean mass ( 33097823 ) Blood urea nitrogen levels ( 31152163 ) Diastolic blood pressure ( 30487518 28135244 27841878 ) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962 ) Estimated glomerular filtration rate ( 31152163 31451708 ) Intelligence (MTAG) ( 29326435 ) joint destruction in rheumatoid arthritis (rapid vs slow) ( 33585033 ) Mean arterial pressure ( 30487518 ) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962 ) Myocardial infarction ( 33532862 ) Night sleep phenotypes ( 27126917 ) Pulmonary arterial hypertension ( 29088834 ) Pulse pressure ( 30578418 ) Response to platinum-based chemotherapy (carboplatin) ( 21844884 ) Urate levels ( 31578528 )
Interacting Genes		38 interacting genes: ABCA1 ABCA13 AKT2 APOB APOC1 APOF APOL1 APP ATP5F1B BRAP CETP CFHR1 CLEC4G CMTM5 FBLN1 GPLD1 HPR HSP90AA1 JAK3 LBP LCAT MAP7D1 NAXE NDRG1 PCMT1 PDE1A PLTP POLR1H PON1 SCARB1 SPP1 TNFRSF10C TOMM20 TREM2 TRIM15 TTR VKORC1 VWF	3 interacting genes: APOA1 APP CALM1
Entrez ID		335	5136
HPRD ID		02517	01387
Ensembl ID		ENSG00000118137	ENSG00000115252
Uniprot IDs		A0A024R3E3 P02647	B7Z226 B7Z3A7 B7Z7A2 P54750 Q9Y633
PDB IDs		1AV1 1GW3 1GW4 1ODP 1ODQ 1ODR 2MSC 2MSD 2MSE 2N5E 3K2S 3R2P 4V6M 6CC9 6CCH 6CCX 6CLZ 6CM1 6PTS 6PTW 6W4E 6W4F 7KJR 7RSC 7RSE 8EQS	Not available
GO Terms Enriched among Interactors		High-density Lipoprotein Particle Regulation Of Lipid Transport Regulation Of Cholesterol Transport Lipid Transport Cholesterol Metabolic Process Sterol Metabolic Process Sterol Transport Steroid Metabolic Process Lipoprotein Metabolic Process Apolipoprotein A-I Binding Cholesterol Transport Positive Regulation Of Cholesterol Transport Plasma Lipoprotein Particle Remodeling Protein-containing Complex Remodeling Extracellular Space Positive Regulation Of Lipid Transport Regulation Of Cholesterol Efflux High-density Lipoprotein Particle Remodeling Extracellular Region Organic Hydroxy Compound Transport Cholesterol Efflux High-density Lipoprotein Particle Binding Alcohol Metabolic Process Lipid Metabolic Process Apolipoprotein Binding Reverse Cholesterol Transport Lipid Homeostasis Extracellular Exosome Very-low-density Lipoprotein Particle Small Molecule Metabolic Process Lipoprotein Biosynthetic Process Cholesterol Transfer Activity Positive Regulation Of Cholesterol Efflux Phosphatidylcholine Binding Positive Regulation Of Transport Phospholipid Transport Cholesterol Homeostasis Sterol Homeostasis Detection Of Molecule Of Bacterial Origin Regulation Of Lipid Storage Regulation Of Transport Low-density Lipoprotein Particle Glycerolipid Metabolic Process Lipopolysaccharide Transport Low-density Lipoprotein Particle Binding Regulation Of Lipid Catabolic Process Triglyceride Metabolic Process Phosphatidylcholine Metabolic Process Regulation Of High-density Lipoprotein Particle Assembly Organophosphate Ester Transport	High-density Lipoprotein Particle Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle Lipoprotein Metabolic Process Cellular Response To Amyloid-beta Response To Amyloid-beta Regulation Of System Process Regulation Of Interleukin-1 Production G Protein-coupled Receptor Signaling Pathway Receptor Ligand Activity Intracellular Signaling Cassette Regulation Of Interleukin-1 Beta Production Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Calcium-mediated Signaling Regulation Of Calcium Ion Transmembrane Transport Positive Regulation Of Synaptic Transmission Positive Regulation Of Endocytosis Positive Regulation Of Small Molecule Metabolic Process Positive Regulation Of Supramolecular Fiber Organization Acetylcholine Receptor Activator Activity Calcium-mediated Signaling Lipoprotein Particle Positive Regulation Of Protein Import Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Peptidyl-methionine Modification High-density Lipoprotein Particle Receptor Binding PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Synaptic Plasticity Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Calcium Ion Transport Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Early Endosome Apolipoprotein A-I Receptor Binding Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Regulation Of Transport Phosphatidylcholine-sterol O-acyltransferase Activator Activity Regulation Of Small Molecule Metabolic Process Lipoprotein Biosynthetic Process