APOA1 and VWF

Data Source:
BioGRID (pull down)

		APOA1	VWF
Description		apolipoprotein A1	von Willebrand factor
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Early Endosome Endoplasmic Reticulum Lumen Cytosol Plasma Membrane Endocytic Vesicle Cytoplasmic Vesicle Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle High-density Lipoprotein Particle Spherical High-density Lipoprotein Particle Secretory Granule Lumen Chylomicron Extracellular Exosome Endocytic Vesicle Lumen Blood Microparticle Extracellular Vesicle	Extracellular Region Extracellular Space Endoplasmic Reticulum Extracellular Matrix Platelet Alpha Granule Platelet Alpha Granule Lumen Weibel-Palade Body Extracellular Exosome Cell Periphery
	Molecular Function	Amyloid-beta Binding Signaling Receptor Binding Lipid Transporter Activity Protein Binding Phospholipid Binding High-density Lipoprotein Particle Binding Lipid Binding Cholesterol Binding Enzyme Binding Heat Shock Protein Binding Apolipoprotein Receptor Binding Apolipoprotein A-I Receptor Binding Identical Protein Binding Protein Homodimerization Activity Chemorepellent Activity Receptor Ligand Activity Phosphatidylcholine-sterol O-acyltransferase Activator Activity High-density Lipoprotein Particle Receptor Binding Lipoprotein Particle Binding Cholesterol Transfer Activity	Protease Binding Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Collagen Binding Immunoglobulin Binding Identical Protein Binding Protein-folding Chaperone Binding
	Biological Process	Endothelial Cell Proliferation Negative Regulation Of Cytokine Production Involved In Immune Response Lipid Metabolic Process Phospholipid Metabolic Process Phosphatidylcholine Biosynthetic Process Cholesterol Biosynthetic Process Lipid Transport Transforming Growth Factor Beta Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Steroid Metabolic Process Cholesterol Metabolic Process Glucocorticoid Metabolic Process Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cholesterol Efflux Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Protein Oxidation Peptidyl-methionine Modification Lipid Storage Regulation Of Intestinal Cholesterol Absorption Cholesterol Transport Adrenal Gland Development Regulation Of Cdc42 Protein Signal Transduction Negative Regulation Of Interleukin-1 Beta Production Cholesterol Efflux Phospholipid Efflux Negative Regulation Of Heterotypic Cell-cell Adhesion Amyloid-beta Formation High-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Assembly High-density Lipoprotein Particle Clearance Positive Regulation Of Rho Protein Signal Transduction Lipoprotein Metabolic Process Lipoprotein Biosynthetic Process Cholesterol Homeostasis Blood Vessel Endothelial Cell Migration Reverse Cholesterol Transport Negative Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Protein Stabilization Negative Chemotaxis Vitamin Transport Positive Regulation Of Stress Fiber Assembly Acylglycerol Homeostasis Phospholipid Homeostasis Negative Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Response To Cytokine Stimulus Triglyceride Homeostasis ERK1 And ERK2 Cascade Cholesterol Import Cellular Response To Lipoprotein Particle Stimulus Positive Regulation Of Cholesterol Metabolic Process Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Phospholipid Efflux Cellular Response To Amyloid-beta	Cell Adhesion Blood Coagulation Hemostasis Response To Wounding Platelet Activation Cell-substrate Adhesion Positive Regulation Of Intracellular Signal Transduction
Pathways		Platelet degranulation ABC transporters in lipid homeostasis PPARA activates gene expression Scavenging of heme from plasma Scavenging by Class B Receptors Scavenging by Class B Receptors Scavenging by Class A Receptors Scavenging by Class A Receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Defective ABCA1 causes TGD Post-translational protein phosphorylation Chylomicron assembly HDL assembly Chylomicron remodeling HDL clearance HDL remodeling Heme signaling Retinoid metabolism and transport Retinoid metabolism and transport Amyloid fiber formation	Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Integrin cell surface interactions Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins GP1b-IX-V activation signalling MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Platelet Adhesion to exposed collagen Platelet Aggregation (Plug Formation) Signaling downstream of RAS mutants Signaling by RAF1 mutants Defective F8 cleavage by thrombin Defective F8 binding to von Willebrand factor Enhanced cleavage of VWF variant by ADAMTS13 Enhanced binding of GP1BA variant to VWF multimer:collagen Defective VWF cleavage by ADAMTS13 variant Defective VWF binding to collagen type I Defective binding of VWF variant to GPIb:IX:V
Drugs		Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Antihemophilic factor, human recombinant Egaptivon pegol Caplacizumab Simoctocog alfa Antihemophilic factor (recombinant), PEGylated Susoctocog alfa Efmoroctocog alfa Lonoctocog alfa Moroctocog alfa Turoctocog alfa pegol Rurioctocog alfa pegol
Diseases		Hypoalphalipoproteinemia Familial amyloidosis	Hemophilia; Hemophilia A (HEMA); Hemophilia B (HEMB); von Willebrand disease (VWD)
GWAS		Allergic rhinitis ( 30013184) Apolipoprotein A1 levels ( 32203549) Body mass index ( 31978080) Cholesterol, total ( 19060911 20686565 24097068) Coronary artery disease ( 24262325) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 21378990) Delirium ( 29631748) Diastolic blood pressure ( 27841878) Fasting triglyceride levels ( 32603185) HDL cholesterol ( 19060906 26582766 20686565 24097068 20864672) HDL cholesterol levels ( 28334899) Hearing function ( 25060954) Hematological and biochemical traits ( 20139978) Hypertriglyceridemia ( 27599772 23505323) Infantile hypertrophic pyloric stenosis ( 23989729) LDL cholesterol ( 20864672 24097068 18179892 20686565 19060911) LDL cholesterol levels ( 28334899) Lipid metabolism phenotypes ( 22286219) Lipid traits ( 24386095) Metabolite levels ( 22916037) Postprandial triglyceride levels ( 32603185) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Systolic blood pressure ( 27841878) Total cholesterol levels ( 28334899 32759990) Total triglycerides levels ( 26690388) Triglyceride levels ( 28334899 28371326 28548082 26763881 32759990) Triglycerides ( 24097068 26582766 21909109 20864672 20686565 20139978 19074352 19060911 19060906 18193046 18193044 18193043) Very low density lipoprotein cholesterol levels ( 28548082)	Coagulation factor levels ( 23267103) Factor VIII levels ( 20231535 30586737) Low vWF levels ( 26486471) Mean platelet volume ( 22139419 27863252 32888494) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912) Platelet count ( 22139419 26805783 32888494) Response to tofacitinib treatment in psoriasis (herpes zoster) ( 33455090) Response to tofacitinib treatment in psoriasis (herpes zoster)(time to event) ( 33455090) Venous thromboembolism ( 31420334) vWF levels ( 20231535 30586737) vWF levels in ischaemic stroke and hyperhomocysteinaemia ( 28495826)
Interacting Genes		38 interacting genes: ABCA1 ABCA13 AKT2 APOB APOC1 APOF APOL1 APP ATP5F1B BRAP CETP CFHR1 CLEC4G CMTM5 FBLN1 GPLD1 HPR HSP90AA1 JAK3 LBP LCAT MAP7D1 NAXE NDRG1 PCMT1 PDE1A PLTP POLR1H PON1 SCARB1 SPP1 TNFRSF10C TOMM20 TREM2 TRIM15 TTR VKORC1 VWF	28 interacting genes: ADAMTS13 ALB APOA1 ATXN7 CACNA1A CALR COL1A1 COL1A2 COL3A1 F8 FGA FGB FGG FURIN FXR1 GP1BA HOXA1 HSPA5 ITGA2B LCOR MAP3K3 NUFIP2 P4HB PROS1 RAC1 SOCS4 TNFRSF11B ZNF512B
Entrez ID		335	7450
HPRD ID		02517	01906
Ensembl ID		ENSG00000118137	ENSG00000110799
Uniprot IDs		A0A024R3E3 P02647	P04275
PDB IDs		1AV1 1GW3 1GW4 1ODP 1ODQ 1ODR 2MSC 2MSD 2MSE 2N5E 3K2S 3R2P 4V6M 6CC9 6CCH 6CCX 6CLZ 6CM1 6PTS 6PTW 6W4E 6W4F 7KJR 7RSC 7RSE 8EQS	1AO3 1ATZ 1AUQ 1FE8 1FNS 1IJB 1IJK 1M10 1OAK 1SQ0 1U0N 1UEX 2ADF 2MHP 2MHQ 3GXB 3HXO 3HXQ 3PPV 3PPW 3PPX 3PPY 3ZQK 4C29 4C2A 4C2B 4DMU 4NT5 5BV8 6FWN 6N29 7EOW 7F49 7KWO 7P4N 7PMV 7PNF 7ZWH 8D3C 8D3D
Enriched GO Terms of Interacting Partners?		High-density Lipoprotein Particle Regulation Of Lipid Transport Regulation Of Cholesterol Transport Lipid Transport Cholesterol Metabolic Process Sterol Metabolic Process Sterol Transport Steroid Metabolic Process Lipoprotein Metabolic Process Apolipoprotein A-I Binding Cholesterol Transport Positive Regulation Of Cholesterol Transport Plasma Lipoprotein Particle Remodeling Protein-containing Complex Remodeling Extracellular Space Positive Regulation Of Lipid Transport Regulation Of Cholesterol Efflux High-density Lipoprotein Particle Remodeling Extracellular Region Organic Hydroxy Compound Transport Cholesterol Efflux High-density Lipoprotein Particle Binding Alcohol Metabolic Process Lipid Metabolic Process Apolipoprotein Binding Reverse Cholesterol Transport Lipid Homeostasis Extracellular Exosome Very-low-density Lipoprotein Particle Small Molecule Metabolic Process Lipoprotein Biosynthetic Process Cholesterol Transfer Activity Positive Regulation Of Cholesterol Efflux Phosphatidylcholine Binding Positive Regulation Of Transport Phospholipid Transport Cholesterol Homeostasis Sterol Homeostasis Detection Of Molecule Of Bacterial Origin Regulation Of Lipid Storage Regulation Of Transport Low-density Lipoprotein Particle Glycerolipid Metabolic Process Lipopolysaccharide Transport Low-density Lipoprotein Particle Binding Regulation Of Lipid Catabolic Process Triglyceride Metabolic Process Phosphatidylcholine Metabolic Process Regulation Of High-density Lipoprotein Particle Assembly Organophosphate Ester Transport	Endoplasmic Reticulum Lumen Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Substrate Adhesion-dependent Cell Spreading Fibrinolysis Protein Activation Cascade Cell-matrix Adhesion Coagulation Blood Coagulation Hemostasis Platelet Alpha Granule Lumen Blood Microparticle Platelet Activation Positive Regulation Of Cell-substrate Adhesion Protein Maturation Regulation Of Cell-substrate Adhesion Cell-substrate Adhesion Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Extracellular Space Negative Regulation Of Coagulation Extracellular Matrix Structural Constituent Positive Regulation Of Rho Protein Signal Transduction Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Regulation Of Hemostasis Fibrinogen Complex Extracellular Region Extracellular Matrix Fibrillar Collagen Trimer Regulation Of Body Fluid Levels Blood Coagulation, Fibrin Clot Formation Zymogen Activation Protein Processing Regulation Of Biological Quality Platelet-derived Growth Factor Binding Plasminogen Activation Cell Surface Regulation Of Signal Transduction Regulation Of Signaling Protein Folding In Endoplasmic Reticulum Regulation Of Cell Communication Positive Regulation Of Heterotypic Cell-cell Adhesion External Side Of Plasma Membrane Negative Regulation Of Multicellular Organismal Process Extracellular Exosome Collagen Type I Trimer Extracellular Matrix Organization Regulation Of Wound Healing Extracellular Structure Organization Platelet Alpha Granule
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