GAB2 and PTPN11

  • Number of citations of the paper that reports this interaction (PMID 10068651)
  • 50
  • Data Source:
  • BioGRID (affinity chromatography technology, affinity chromatography technology)
  • HPRD (in vivo, in vitro)

GAB2

PTPN11

Gene Name GRB2-associated binding protein 2 protein tyrosine phosphatase, non-receptor type 11
Image
Gene Ontology Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Alzheimer's disease (late onset) ( 17553421)
  • Menarche (age at onset) ( 21102462)
Protein-Protein Interactions 28 interactors: AKT1 ARHGAP32 CD247 CRKL EPOR ETV6 GAB1 GRAP GRAP2 GRB2 INPP5D LAT LCK LYN MAPK1 MAPK3 MAPK4 NCK1 PIK3R1 PLCG1 PLCG2 PTPN11 PTPN6 SHC1 SRC SYK TNFRSF11A ZAP70 114 interactors: ACTN4 ARHGAP1 AXL BCR BDKRB2 BTLA C6orf25 CAT CAV1 CBL CCKBR CD33 CDH5 CEACAM1 CHUK CRKL CSF2RB CSF3R CTLA4 CXCR4 DAB1 DDR1 EGFR EPHA2 EPOR ERBB2 FCRL3 FLT1 FLT4 FRS2 FRS3 FYN GAB1 GAB2 GAB3 GHR GRB2 GRIN2B HNRNPU IFNAR1 IFNGR1 IGF1R IL4R IL6ST INPP5D INSR IRS1 IRS2 IRS4 JAK1 JAK2 KDR KIR2DL5A KIT KLRC1 LAIR1 LCK LEPR LIFR LILRB4 MAP3K4 MAP3K5 MAPK3 MET MPL MPZL1 MS4A2 MVP NEDD9 NTRK1 NTRK2 PAG1 PDGFRA PDGFRB PECAM1 PIK3CG PIK3R1 PILRA PILRB PLCG1 PRKCA PRKCB PRKCH PRLR PTK2 PTK2B PTPN6 PXN RET ROS1 RPIA SELE SHC1 SIGLEC11 SIGLEC12 SIGLEC7 SIRPA SIT1 SLAMF1 SLAMF6 SOCS3 SOS1 SPRY2 SRC STAT1 STAT3 STAT5A STAT5B SYNCRIP TEK TIE1 TNFRSF1A TREML1 TRIM32
Entrez ID 9846 5781
HPRD ID 05866 01470
Ensembl ID ENSG00000033327 ENSG00000179295
Uniprot IDs Q9UQC2 Q06124
PDB IDs 2VWF 2W0Z 2SHP 3B7O 3MOW 3O5X 3TKZ 3TL0 4DGP 4DGX 4GWF 4H1O 4H34 4JE4
Enriched GO Terms of Interacting Partners?
Tagcloud ?
adaptor  adenocarcinomas  compensate  contribution  deletion  demonstrating  driven  egfr  egfrl858r  erbb2  erbb3  gab1  inducible  initiate  inositol  member  met  mutant  observations  phosphatidyl  pi3k  plasticity  remarkable  retained  tamoxifen  tetracycline  tkis  tumorigenesis 
absolute  case  cases  count  died  eleven  female  indispensable  interval  jmml  juvenile  male  median  monocytes  mutation  myelomonocytic  observation  obviously  onset  peripheral  platelet  plt  progressive  ras  retrospectively  slow  sure  wbc  white 
Tagcloud (Difference) ?
adaptor  adenocarcinomas  compensate  contribution  deletion  demonstrating  driven  egfr  egfrl858r  erbb2  erbb3  gab1  inducible  initiate  inositol  member  met  mutant  observations  phosphatidyl  pi3k  plasticity  remarkable  retained  tamoxifen  tetracycline  tkis  tumorigenesis 
absolute  case  cases  count  died  eleven  female  indispensable  interval  jmml  juvenile  male  median  monocytes  mutation  myelomonocytic  observation  obviously  onset  peripheral  platelet  plt  progressive  ras  retrospectively  slow  sure  wbc  white 
Tagcloud (Intersection) ?