GAB2 and PTPN6

  • Number of citations of the paper that reports this interaction (PMID 11895767)
  • 17
  • Data Source:
  • BioGRID (affinity chromatography technology)
  • HPRD (in vitro)

GAB2

PTPN6

Gene Name GRB2-associated binding protein 2 protein tyrosine phosphatase, non-receptor type 6
Image
Gene Ontology Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Alzheimer's disease (late onset) ( 17553421)
  • Menarche (age at onset) ( 21102462)
Protein-Protein Interactions 28 interactors: AKT1 ARHGAP32 CD247 CRKL EPOR ETV6 GAB1 GRAP GRAP2 GRB2 INPP5D LAT LCK LYN MAPK1 MAPK3 MAPK4 NCK1 PIK3R1 PLCG1 PLCG2 PTPN11 PTPN6 SHC1 SRC SYK TNFRSF11A ZAP70 98 interactors: ABL1 ACTN1 ACTN4 BCR BLNK BTLA C6orf25 CAV1 CBL CD22 CD247 CD300LF CD33 CD5 CD72 CD79A CD79B CEACAM1 CLEC4A CSF2RB CTNNB1 CTNND1 CUZD1 CXCR4 DOK1 EGFR EPOR ESR1 FAS FCGR2B FCRL3 FHL3 FLT3 GAB2 GHR GRB2 HOXA10 IFNAR1 IL2RB IL4R IL6ST INSR IRS2 IRS4 JAK1 JAK2 JAK3 KDR KHDRBS1 KIR2DL3 KIR2DL5A KIT KLRAP1 KLRB1 KLRC1 LAIR1 LCK LCP2 LIFR LILRB2 LILRB4 LYN MS4A2 MYH9 NOS1 PAG1 PECAM1 PIK3R1 PILRA PILRB PRKCA PRKCD PTK2B PTPN11 PTPRC ROS1 SHC1 SIGLEC10 SIGLEC11 SIGLEC12 SIRPA SLAMF6 SOS1 SPATA2 SRC SSTR2 STAT5B STAT6 SYK TFG TLR10 TMEM62 TNFRSF1A TRAF6 TREML1 TYK2 VAV1 ZAP70
Entrez ID 9846 5777
HPRD ID 05866 01475
Ensembl ID ENSG00000033327 ENSG00000111679
Uniprot IDs Q9UQC2 P29350 Q53XS4
PDB IDs 2VWF 2W0Z 1FPR 1GWZ 1X6C 2B3O 2RMX 2YU7 3PS5 4GRY 4GRZ 4GS0 4HJP 4HJQ
Enriched GO Terms of Interacting Partners?
Tagcloud ?
adaptor  adenocarcinomas  compensate  contribution  deletion  demonstrating  driven  egfr  egfrl858r  erbb2  erbb3  gab1  inducible  initiate  inositol  member  met  mutant  observations  phosphatidyl  pi3k  plasticity  remarkable  retained  tamoxifen  tetracycline  tkis  tumorigenesis 
a2  ag  cd45  chimera  chimeras  chimeric  coupling  diminished  enzymatic  fails  hcp  hemopoietic  initiated  inositol  j45  jurkat  ligation  lymphoid  phosphatase  phospholipase  phosphotyrosine  ptp1c  rescue  shp  shptp  surprisingly  tcr  transduction  unlike 
Tagcloud (Difference) ?
adaptor  adenocarcinomas  compensate  contribution  deletion  demonstrating  driven  egfr  egfrl858r  erbb2  erbb3  gab1  inducible  initiate  member  met  mutant  observations  phosphatidyl  pi3k  plasticity  remarkable  retained  tamoxifen  tetracycline  tkis  tumorigenesis 
a2  ag  cd45  chimera  chimeras  chimeric  coupling  diminished  enzymatic  fails  hcp  hemopoietic  initiated  j45  jurkat  ligation  lymphoid  phosphatase  phospholipase  phosphotyrosine  ptp1c  rescue  shp  shptp  surprisingly  tcr  transduction  unlike 
Tagcloud (Intersection) ?
inositol