GAB2 and GRAP

Number of citations of the paper that reports this interaction (PubMedID 10391903)
0

Data Source:
BioGRID (pull down)

		GAB2	GRAP
Description		GRB2 associated binding protein 2	GRB2 related adaptor protein
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Membrane Raft	Nucleoplasm Cytoplasm Cytosol Plasma Membrane COP9 Signalosome Membrane Synapse Presynapse
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding	Phosphotyrosine Residue Binding Epidermal Growth Factor Receptor Binding Protein Binding
	Biological Process	Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Population Proliferation Osteoclast Differentiation Positive Regulation Of Mast Cell Degranulation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction	Signal Transduction Ras Protein Signal Transduction Cell-cell Signaling Sensory Perception Of Sound Regulation Of MAPK Cascade
Pathways		PI3K Cascade PIP3 activates AKT signaling Signaling by SCF-KIT Signaling by cytosolic FGFR1 fusion mutants Constitutive Signaling by Aberrant PI3K in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Role of LAT2/NTAL/LAB on calcium mobilization PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RET signaling Interleukin-15 signaling Interleukin receptor SHC signaling FLT3 Signaling FLT3 Signaling STAT5 Activation Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) Signaling by CSF1 (M-CSF) in myeloid cells STAT5 activation downstream of FLT3 ITD mutants Signaling by FLT3 fusion proteins Signaling by FLT3 fusion proteins Signaling by FLT3 ITD and TKD mutants Signaling by FLT3 ITD and TKD mutants	Signaling by SCF-KIT
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Alzheimer's disease (late onset) ( 17553421) Alzheimer's disease (survival time) ( 25649651) Aspartate aminotransferase levels ( 33547301) Blond vs. brown/black hair color ( 30531825) Body mass index ( 28892062) Brown vs. black hair color ( 30531825) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Creatine kinase levels ( 29403010) Creatinine levels ( 29403010) Diastolic blood pressure ( 30224653) Estimated glomerular filtration rate ( 31152163 30604766) Glomerular filtration rate ( 29403010) Hair color ( 29662168) High light scatter reticulocyte percentage of red cells ( 32888494) Intraocular pressure ( 29785010) Lactate dehydrogenase levels ( 29403010) LDL cholesterol ( 30275531) Lipid traits (pleiotropy) (HIPO component 2) ( 30289880) Menarche (age at onset) ( 25231870 21102462) Platelet distribution width ( 32888494) Testicular germ cell tumor ( 28604732 28604728 26503584) Total cholesterol levels ( 30275531) Tourette syndrome ( 30818990) Triglyceride levels ( 32203549) Triglycerides ( 30275531)	Copper levels ( 26025379)
Interacting Genes		30 interacting genes: AKT1 ARHGAP32 CD247 CRKL EPOR ETV6 GAB1 GRAP GRAP2 GRB2 INPP5D LAT LCK LYN MAPK1 MAPK3 MAPK4 MYO15B NCK1 PIK3R1 PLCG1 PLCG2 PTPN11 PTPN6 SHC1 SNCA SRC SYK TNFRSF11A ZAP70	18 interacting genes: ARHGAP32 DPPA4 EPOR FASLG FYN GAB2 KHDRBS1 KIT LAT LCK PLCG1 PRRG4 RBPMS REL SHC1 SOS1 TOX TRIM21
Entrez ID		9846	10750
HPRD ID		05866	05062
Ensembl ID		ENSG00000033327	ENSG00000154016
Uniprot IDs		Q9UQC2	I3L2P9 Q13588
PDB IDs		2VWF 2W0Z 5EWZ 5EXA 6Y3R 6Y3S 6ZVB 6ZVC 6ZVD 6ZVE
Enriched GO Terms of Interacting Partners?		Phosphotyrosine Residue Binding Immune Response-activating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of MAPK Cascade Positive Regulation Of Immune System Process T Cell Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Immune Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Immune System Process Positive Regulation Of Immune Response ERBB Signaling Pathway Regulation Of Intracellular Signal Transduction Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Intracellular Signaling Cassette Leukocyte Activation Positive Regulation Of MAPK Cascade Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Activation T Cell Costimulation Immune System Process Cell-cell Junction Regulation Of T Cell Activation Cell Activation Regulation Of Lymphocyte Activation Regulation Of Defense Response Peptidyl-tyrosine Phosphorylation B Cell Receptor Signaling Pathway Fc Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Lymphocyte Activation Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of T Cell Activation Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Cell Activation Negative Regulation Of Immune System Process Regulation Of Multicellular Organismal Process Cytokine-mediated Signaling Pathway	Fc Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction T Cell Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Immune System Process Immune System Process Positive Regulation Of Intracellular Signal Transduction Signal Transduction Cell Surface Receptor Signaling Pathway Immune Response-activating Signaling Pathway Intracellular Signaling Cassette Regulation Of Immune System Process Regulation Of Immune Response Enzyme-linked Receptor Protein Signaling Pathway Activation Of Immune Response CD8 Receptor Binding Lymphocyte Activation Regulation Of Multicellular Organismal Process SH2 Domain Binding Regulation Of Intracellular Signal Transduction T Cell Activation Neurotrophin TRKA Receptor Binding Positive Regulation Of Signal Transduction Leukocyte Activation Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Sequestering Of Calcium Ion Erythropoietin-mediated Signaling Pathway CD4 Receptor Binding Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of T Cell Activation Cell Activation Positive Regulation Of Immune Response Phospholipase Activator Activity Regulation Of Multicellular Organismal Development Membrane Raft T Cell Receptor Binding ERBB Signaling Pathway Leukocyte Migration Calcium Ion Transmembrane Import Into Cytosol Calcium Ion Transport Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Phosphatidylinositol 3-kinase Binding Regulation Of Lymphocyte Activation Phospholipase Binding
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